Investigation of the Synergistic Protective Effect of Natural Antioxidants on DNA Damage
Three different natural antioxidants (tea polyphenol, ferulic acid, α-lipoic acid) and their mixture were estimated for the potential protective action on DNA damage. Antioxidant activity of the products was evaluated through protection against DNA damage induced by 2,2′-azobis(2-amidinopropane) dih...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2023-08, Vol.57 (5), p.663-668 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Shang, Mengdi Zhong, Hanshi Gao, Xiyue Shen, Meng Cai, Yanfei Yang, Zhaoqi |
| description | Three different natural antioxidants (tea polyphenol, ferulic acid, α-lipoic acid) and their mixture were estimated for the potential protective action on DNA damage. Antioxidant activity of the products was evaluated through protection against DNA damage induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH). In this system, the mixture of tea polyphenol and ferulic acid showed maximum potential activity, while the α-lipoic acid alone was determined as the weakest antioxidant in gel electrophoresis assay. Results of this study demonstrated that tea polyphenol, ferulic acid and α-lipoic acid exhibited good synergistic effects, and all the mixtures were more resistant than any antioxidant alone. |
| doi_str_mv | 10.1007/s11094-023-02935-9 |
| format | Article |
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Antioxidant activity of the products was evaluated through protection against DNA damage induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH). In this system, the mixture of tea polyphenol and ferulic acid showed maximum potential activity, while the α-lipoic acid alone was determined as the weakest antioxidant in gel electrophoresis assay. Results of this study demonstrated that tea polyphenol, ferulic acid and α-lipoic acid exhibited good synergistic effects, and all the mixtures were more resistant than any antioxidant alone.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-023-02935-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Antioxidants DNA DNA damage Investigations Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy |
| title | Investigation of the Synergistic Protective Effect of Natural Antioxidants on DNA Damage |
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