The Impact of Mild Chronic Stress and Maternal Experience in the IFmr1/I Mouse Model of Fragile X Syndrome

Fragile X syndrome (FXS) is a pervasive developmental disorder and the most common monogenic cause of autism spectrum disorder (ASD). Female heterozygous (HET) carriers play a major role in the transmission of the pathology and present several FXS- and ASD-like behavioral alterations. Despite their...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of molecular sciences 2023-07, Vol.24 (14)
Hauptverfasser: Subashi, Enejda, Lemaire, Valerie, Petroni, Valeria, Pietropaolo, Susanna
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 14
container_start_page
container_title International journal of molecular sciences
container_volume 24
creator Subashi, Enejda
Lemaire, Valerie
Petroni, Valeria
Pietropaolo, Susanna
description Fragile X syndrome (FXS) is a pervasive developmental disorder and the most common monogenic cause of autism spectrum disorder (ASD). Female heterozygous (HET) carriers play a major role in the transmission of the pathology and present several FXS- and ASD-like behavioral alterations. Despite their clear genetic origins, FXS symptoms are known to be modulated by environmental factors, e.g., exposure to chronic stress, especially during critical life periods, such as pregnancy. Pregnancy, together with pups’ care, constitutes maternal experience, i.e., another powerful environmental factor affecting several neurobehavioral functions in females. Here we investigated the impact of maternal experience on the long-term effects of stress in Fmr1-HET female mice. Our findings demonstrated that the behavioral abnormalities of HET females, i.e., hyperactivity and memory deficits, were unaffected by stress or maternal experience. In contrast, stress, independently of maternal experience, induced the appearance of cognitive deficits in WT mice. Maternal experience increased anxiety levels in all mice and enhanced their corticosterone levels, concomitantly promoting the effects of stress on social communication and adrenal glands. In translational terms, these results advance our understanding of the environmental modulation of the behavioral alterations observed in FXS female carriers and highlight the long-term impact of maternal experience and its interactions with chronic stress.
doi_str_mv 10.3390/ijms241411398
format Article
fullrecord <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A759152881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A759152881</galeid><sourcerecordid>A759152881</sourcerecordid><originalsourceid>FETCH-LOGICAL-g671-e95b241ad36c49025ea62fd73ba9cfe9d3caeb808c35076b5eea641171edc6e03</originalsourceid><addsrcrecordid>eNptj71PwzAUxD2ARCmM7E9iTuuPOInHqmqgUiuGdmCrHPuldZU4lR0k-O9xBQMDOund8rvTPUKeGJ0JoejcnfvIc5YzJlR1QyYs5zyjtCjvyH2MZ0q54FJNyHl_Qlj3F21GGFrYus7C8hQG7wzsxoAxgvYWtnrE4HUHq88LBofeIDgP4zVc94HN17AdPiKma7G7NtVBH12H8A67L2_D0OMDuW11F_Hx16dkX6_2y9ds8_ayXi422bEoWYZKNmm4tqIwuaJcoi54a0vRaGVaVFYYjU1FKyMkLYtGYgLSmyVDawqkYkqef2qPusOD8-0wBm16F81hUUrFJK8qlqjZP1SSxd6ZwWObxv8NfAO-HWaG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Impact of Mild Chronic Stress and Maternal Experience in the IFmr1/I Mouse Model of Fragile X Syndrome</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Subashi, Enejda ; Lemaire, Valerie ; Petroni, Valeria ; Pietropaolo, Susanna</creator><creatorcontrib>Subashi, Enejda ; Lemaire, Valerie ; Petroni, Valeria ; Pietropaolo, Susanna</creatorcontrib><description>Fragile X syndrome (FXS) is a pervasive developmental disorder and the most common monogenic cause of autism spectrum disorder (ASD). Female heterozygous (HET) carriers play a major role in the transmission of the pathology and present several FXS- and ASD-like behavioral alterations. Despite their clear genetic origins, FXS symptoms are known to be modulated by environmental factors, e.g., exposure to chronic stress, especially during critical life periods, such as pregnancy. Pregnancy, together with pups’ care, constitutes maternal experience, i.e., another powerful environmental factor affecting several neurobehavioral functions in females. Here we investigated the impact of maternal experience on the long-term effects of stress in Fmr1-HET female mice. Our findings demonstrated that the behavioral abnormalities of HET females, i.e., hyperactivity and memory deficits, were unaffected by stress or maternal experience. In contrast, stress, independently of maternal experience, induced the appearance of cognitive deficits in WT mice. Maternal experience increased anxiety levels in all mice and enhanced their corticosterone levels, concomitantly promoting the effects of stress on social communication and adrenal glands. In translational terms, these results advance our understanding of the environmental modulation of the behavioral alterations observed in FXS female carriers and highlight the long-term impact of maternal experience and its interactions with chronic stress.</description><identifier>ISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241411398</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Autism ; Corticosterone ; Fragile X syndrome ; Pregnancy</subject><ispartof>International journal of molecular sciences, 2023-07, Vol.24 (14)</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Subashi, Enejda</creatorcontrib><creatorcontrib>Lemaire, Valerie</creatorcontrib><creatorcontrib>Petroni, Valeria</creatorcontrib><creatorcontrib>Pietropaolo, Susanna</creatorcontrib><title>The Impact of Mild Chronic Stress and Maternal Experience in the IFmr1/I Mouse Model of Fragile X Syndrome</title><title>International journal of molecular sciences</title><description>Fragile X syndrome (FXS) is a pervasive developmental disorder and the most common monogenic cause of autism spectrum disorder (ASD). Female heterozygous (HET) carriers play a major role in the transmission of the pathology and present several FXS- and ASD-like behavioral alterations. Despite their clear genetic origins, FXS symptoms are known to be modulated by environmental factors, e.g., exposure to chronic stress, especially during critical life periods, such as pregnancy. Pregnancy, together with pups’ care, constitutes maternal experience, i.e., another powerful environmental factor affecting several neurobehavioral functions in females. Here we investigated the impact of maternal experience on the long-term effects of stress in Fmr1-HET female mice. Our findings demonstrated that the behavioral abnormalities of HET females, i.e., hyperactivity and memory deficits, were unaffected by stress or maternal experience. In contrast, stress, independently of maternal experience, induced the appearance of cognitive deficits in WT mice. Maternal experience increased anxiety levels in all mice and enhanced their corticosterone levels, concomitantly promoting the effects of stress on social communication and adrenal glands. In translational terms, these results advance our understanding of the environmental modulation of the behavioral alterations observed in FXS female carriers and highlight the long-term impact of maternal experience and its interactions with chronic stress.</description><subject>Autism</subject><subject>Corticosterone</subject><subject>Fragile X syndrome</subject><subject>Pregnancy</subject><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj71PwzAUxD2ARCmM7E9iTuuPOInHqmqgUiuGdmCrHPuldZU4lR0k-O9xBQMDOund8rvTPUKeGJ0JoejcnfvIc5YzJlR1QyYs5zyjtCjvyH2MZ0q54FJNyHl_Qlj3F21GGFrYus7C8hQG7wzsxoAxgvYWtnrE4HUHq88LBofeIDgP4zVc94HN17AdPiKma7G7NtVBH12H8A67L2_D0OMDuW11F_Hx16dkX6_2y9ds8_ayXi422bEoWYZKNmm4tqIwuaJcoi54a0vRaGVaVFYYjU1FKyMkLYtGYgLSmyVDawqkYkqef2qPusOD8-0wBm16F81hUUrFJK8qlqjZP1SSxd6ZwWObxv8NfAO-HWaG</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Subashi, Enejda</creator><creator>Lemaire, Valerie</creator><creator>Petroni, Valeria</creator><creator>Pietropaolo, Susanna</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20230701</creationdate><title>The Impact of Mild Chronic Stress and Maternal Experience in the IFmr1/I Mouse Model of Fragile X Syndrome</title><author>Subashi, Enejda ; Lemaire, Valerie ; Petroni, Valeria ; Pietropaolo, Susanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g671-e95b241ad36c49025ea62fd73ba9cfe9d3caeb808c35076b5eea641171edc6e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autism</topic><topic>Corticosterone</topic><topic>Fragile X syndrome</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Subashi, Enejda</creatorcontrib><creatorcontrib>Lemaire, Valerie</creatorcontrib><creatorcontrib>Petroni, Valeria</creatorcontrib><creatorcontrib>Pietropaolo, Susanna</creatorcontrib><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Subashi, Enejda</au><au>Lemaire, Valerie</au><au>Petroni, Valeria</au><au>Pietropaolo, Susanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Mild Chronic Stress and Maternal Experience in the IFmr1/I Mouse Model of Fragile X Syndrome</atitle><jtitle>International journal of molecular sciences</jtitle><date>2023-07-01</date><risdate>2023</risdate><volume>24</volume><issue>14</issue><issn>1422-0067</issn><abstract>Fragile X syndrome (FXS) is a pervasive developmental disorder and the most common monogenic cause of autism spectrum disorder (ASD). Female heterozygous (HET) carriers play a major role in the transmission of the pathology and present several FXS- and ASD-like behavioral alterations. Despite their clear genetic origins, FXS symptoms are known to be modulated by environmental factors, e.g., exposure to chronic stress, especially during critical life periods, such as pregnancy. Pregnancy, together with pups’ care, constitutes maternal experience, i.e., another powerful environmental factor affecting several neurobehavioral functions in females. Here we investigated the impact of maternal experience on the long-term effects of stress in Fmr1-HET female mice. Our findings demonstrated that the behavioral abnormalities of HET females, i.e., hyperactivity and memory deficits, were unaffected by stress or maternal experience. In contrast, stress, independently of maternal experience, induced the appearance of cognitive deficits in WT mice. Maternal experience increased anxiety levels in all mice and enhanced their corticosterone levels, concomitantly promoting the effects of stress on social communication and adrenal glands. In translational terms, these results advance our understanding of the environmental modulation of the behavioral alterations observed in FXS female carriers and highlight the long-term impact of maternal experience and its interactions with chronic stress.</abstract><pub>MDPI AG</pub><doi>10.3390/ijms241411398</doi></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2023-07, Vol.24 (14)
issn 1422-0067
language eng
recordid cdi_gale_infotracmisc_A759152881
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central
subjects Autism
Corticosterone
Fragile X syndrome
Pregnancy
title The Impact of Mild Chronic Stress and Maternal Experience in the IFmr1/I Mouse Model of Fragile X Syndrome
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T13%3A48%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Impact%20of%20Mild%20Chronic%20Stress%20and%20Maternal%20Experience%20in%20the%20IFmr1/I%20Mouse%20Model%20of%20Fragile%20X%20Syndrome&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Subashi,%20Enejda&rft.date=2023-07-01&rft.volume=24&rft.issue=14&rft.issn=1422-0067&rft_id=info:doi/10.3390/ijms241411398&rft_dat=%3Cgale%3EA759152881%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A759152881&rfr_iscdi=true