Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D[sub.3] and Identification of Their Metabolites

Vitamin D[sub.3] (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D[sub.3] (6a) and 4β,25-dihydroxyvitamin D[sub.3] (6b) are both produced from 25-hydroxyvitamin D[sub.3] (2) by CYP3A4. However, 6b is d...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2023-06, Vol.13 (7)
Hauptverfasser:	Mizumoto, Yuka, Sakamoto, Ryota, Iijima, Kazuto, Nakaya, Naoto, Odagi, Minami, Tera, Masayuki, Hirokawa, Takatsugu, Sakaki, Toshiyuki, Yasuda, Kaori, Nagasawa, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Calcitriol Care and treatment Diagnosis Dosage and administration Liver diseases Metabolites Osteomalacia Risk factors
Online-Zugang:	Volltext
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