Distribution characteristics of Fc[mu]R positive cells in small intestinal lymph nodes of Bactrian camel
Exploring the expression characteristics of Fc[mu]R in small intestinal lymph nodes of bactrian camels can lay the foundation for further revealing the function of Fc[mu]R. The Fc[mu]R expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immu...
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| Veröffentlicht in: | PloS one 2023-07, Vol.18 (7), p.e0287329 |
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| creator | Fei, Xie Li, Jian fei Fang, Ying dong Liu, Li ping Liu, Ke Jiang Zeng, Wei wei Wang, Wen hui |
| description | Exploring the expression characteristics of Fc[mu]R in small intestinal lymph nodes of bactrian camels can lay the foundation for further revealing the function of Fc[mu]R. The Fc[mu]R expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immunohistochemical staining and statistical analysis. Fc[mu]R positive cells were mainly located in the lymphoid follicles and their numbers decreased in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes, and the number of positive cells was statistically significant between different intestinal segments (P |
| doi_str_mv | 10.1371/journal.pone.0287329 |
| format | Article |
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The Fc[mu]R expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immunohistochemical staining and statistical analysis. Fc[mu]R positive cells were mainly located in the lymphoid follicles and their numbers decreased in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes, and the number of positive cells was statistically significant between different intestinal segments (P<0.05). The Fc[mu]R is expressed in lymphoid follicular B cells, which not only facilitates the body's ability to regulate secretory IgM levels, but also acts as a local immune defence barrier. The small intestine has dual functions of immune tolerance and immune response, the proximal part mainly focuses on immune tolerance, and the distal part mainly focuses on immune response. This distribution ensures the unity of the duodenal absorption and immune defence, and also significantly increases the efficiency of the entire small intestine, which is why the number of Fc[mu]R positive cells decreases in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0287329</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Analysis ; Antibodies ; B cells ; Camels ; Genetic aspects ; Identification and classification ; Immunoglobulin genes ; Immunohistochemistry ; Lymph nodes ; Physiological aspects ; Varieties ; Viral antibodies</subject><ispartof>PloS one, 2023-07, Vol.18 (7), p.e0287329</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,27933,27934</link.rule.ids></links><search><creatorcontrib>Fei, Xie</creatorcontrib><creatorcontrib>Li, Jian fei</creatorcontrib><creatorcontrib>Fang, Ying dong</creatorcontrib><creatorcontrib>Liu, Li ping</creatorcontrib><creatorcontrib>Liu, Ke Jiang</creatorcontrib><creatorcontrib>Zeng, Wei wei</creatorcontrib><creatorcontrib>Wang, Wen hui</creatorcontrib><title>Distribution characteristics of Fc[mu]R positive cells in small intestinal lymph nodes of Bactrian camel</title><title>PloS one</title><description>Exploring the expression characteristics of Fc[mu]R in small intestinal lymph nodes of bactrian camels can lay the foundation for further revealing the function of Fc[mu]R. The Fc[mu]R expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immunohistochemical staining and statistical analysis. Fc[mu]R positive cells were mainly located in the lymphoid follicles and their numbers decreased in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes, and the number of positive cells was statistically significant between different intestinal segments (P<0.05). The Fc[mu]R is expressed in lymphoid follicular B cells, which not only facilitates the body's ability to regulate secretory IgM levels, but also acts as a local immune defence barrier. The small intestine has dual functions of immune tolerance and immune response, the proximal part mainly focuses on immune tolerance, and the distal part mainly focuses on immune response. This distribution ensures the unity of the duodenal absorption and immune defence, and also significantly increases the efficiency of the entire small intestine, which is why the number of Fc[mu]R positive cells decreases in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes.</description><subject>Analysis</subject><subject>Antibodies</subject><subject>B cells</subject><subject>Camels</subject><subject>Genetic aspects</subject><subject>Identification and classification</subject><subject>Immunoglobulin genes</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Physiological aspects</subject><subject>Varieties</subject><subject>Viral antibodies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkU1Lw0AQhoMoWKv_wMOCIHhI3I_sbnqs1WpBKNSPi0jZbCbNlk1SshvRf-9SPbTgQeYww_C87zAzUXROcEKYJNfrtu8aZZNN20CCaSYZHR1EAzJiNBYUs8Od-jg6cW6NMWeZEIOoujXOdybvvWkbpCvVKe2hC02jHWpLNNVvdf--QJvWGW8-AGmw1iHTIFcra0PhIcBhPLJf9aZCTVvAVnkTnDqjgquqwZ5GR6WyDs5-8zB6md49Tx7ix_n9bDJ-jFdECBJnJCul0lyD5HmZgRY5IVyTQhItgeYcRiOgKZeYqQJynmNaiFSlQFIuWE7ZMLr48V0pC0vTlK0PK9XG6eVYcplxjjMSqOQPKkQBtdHhjKUJ_T3B1Z4gMB4-_Ur1zi1nT4v_s_PXffZyh61AWV-51m7f4XbBb_vPlaQ</recordid><startdate>20230720</startdate><enddate>20230720</enddate><creator>Fei, Xie</creator><creator>Li, Jian fei</creator><creator>Fang, Ying dong</creator><creator>Liu, Li ping</creator><creator>Liu, Ke Jiang</creator><creator>Zeng, Wei wei</creator><creator>Wang, Wen hui</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20230720</creationdate><title>Distribution characteristics of Fc[mu]R positive cells in small intestinal lymph nodes of Bactrian camel</title><author>Fei, Xie ; Li, Jian fei ; Fang, Ying dong ; Liu, Li ping ; Liu, Ke Jiang ; Zeng, Wei wei ; Wang, Wen hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1661-818f7ac5ce75bf8ec6b115c1d71c7e2b5e99e245703adeb5b02d64a4e14563b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Antibodies</topic><topic>B cells</topic><topic>Camels</topic><topic>Genetic aspects</topic><topic>Identification and classification</topic><topic>Immunoglobulin genes</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Physiological aspects</topic><topic>Varieties</topic><topic>Viral antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fei, Xie</creatorcontrib><creatorcontrib>Li, Jian fei</creatorcontrib><creatorcontrib>Fang, Ying dong</creatorcontrib><creatorcontrib>Liu, Li ping</creatorcontrib><creatorcontrib>Liu, Ke Jiang</creatorcontrib><creatorcontrib>Zeng, Wei wei</creatorcontrib><creatorcontrib>Wang, Wen hui</creatorcontrib><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fei, Xie</au><au>Li, Jian fei</au><au>Fang, Ying dong</au><au>Liu, Li ping</au><au>Liu, Ke Jiang</au><au>Zeng, Wei wei</au><au>Wang, Wen hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution characteristics of Fc[mu]R positive cells in small intestinal lymph nodes of Bactrian camel</atitle><jtitle>PloS one</jtitle><date>2023-07-20</date><risdate>2023</risdate><volume>18</volume><issue>7</issue><spage>e0287329</spage><pages>e0287329-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Exploring the expression characteristics of Fc[mu]R in small intestinal lymph nodes of bactrian camels can lay the foundation for further revealing the function of Fc[mu]R. The Fc[mu]R expression characteristics were systematically analysed by using prokaryotic expression, antibody preparation, immunohistochemical staining and statistical analysis. Fc[mu]R positive cells were mainly located in the lymphoid follicles and their numbers decreased in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes, and the number of positive cells was statistically significant between different intestinal segments (P<0.05). The Fc[mu]R is expressed in lymphoid follicular B cells, which not only facilitates the body's ability to regulate secretory IgM levels, but also acts as a local immune defence barrier. The small intestine has dual functions of immune tolerance and immune response, the proximal part mainly focuses on immune tolerance, and the distal part mainly focuses on immune response. This distribution ensures the unity of the duodenal absorption and immune defence, and also significantly increases the efficiency of the entire small intestine, which is why the number of Fc[mu]R positive cells decreases in the order of duodenal lymph nodes, jejunal lymph nodes and ileal lymph nodes.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0287329</doi><tpages>e0287329</tpages></addata></record> |
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| subjects | Analysis Antibodies B cells Camels Genetic aspects Identification and classification Immunoglobulin genes Immunohistochemistry Lymph nodes Physiological aspects Varieties Viral antibodies |
| title | Distribution characteristics of Fc[mu]R positive cells in small intestinal lymph nodes of Bactrian camel |
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