The potential of dynamic [99m.sup.Tc]-sestamibi cadmium zinc telluride- single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
Aims Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantifica...
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| creator | Yoshida, Satoya Unno, Kazumasa Nanasato, Mamoru Niimi, Takanaga Inukai, Kohei Morisaki, Hidenori Hattori, Tomoki Hirose, Miku Hayashi, Takumi Uchida, Noriya Simoda, Masahiro Oishi, Hideo Ando, Monami Hirayama, Kenshi Takenaka, Masaki Maeda, Mayuho Yoshida, Ruka Ogura, Yasuhiro Suzuki, Hirohiko Furusawa, Kenji Morimoto, Ryota Kato, Katsuhiko Isobe, Satoshi Yoshida, Yukihiko Murohara, Toyoaki |
| description | Aims Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantification of absolute myocardial blood flow and myocardial flow reserve (MFR) in patients with coronary artery disease. However, the potential of CZT- SPECT assessing for CMD has never been evaluated in patients with HFpEF. Methods and results The clinical records of 127 consecutive patients who underwent dynamic CZT-SPECT were retrospectively reviewed. Rest and stress scanning were started simultaneously with 3 and 9 MBq/kg of [99m.sup.Tc]-sestamibi administration, respectively. Dynamic CZT-SPECT imaging data were analysed using a net-retention model with commercially available software. Transthoracic echocardiography was performed in all patients. The MFR value was significantly lower in the HFpEF group (mean [+ or -] SEM = 2.00 [+ or -] 0.097) than that in the non-HFpEF group (mean [+ or -] SEM = 2.74 [+ or -] 0.14, P = 0.0004). A receiver operating characteristic analysis indicated that if a cut-off value of 2.525 was applied, MFR could efficiently distinguish HFpEF from non-HFpEF. Heart failure with preserved ejection fraction had a consistently low MFR, regardless of the diastolic dysfunction score. Heart failure with preserved ejection fraction patients with MFR values lower than 2.075 had a significantly higher incidence of heart failure exacerbation. Conclusion Myocardial flow reserve assessed by CZT-SPECT was significantly reduced in patients with HFpEF. A lower MFR was asso ciated with a higher hospitalization rate in these patients. Myocardial flow reserve assessed by CZT-SPECT has the potential to predict future adverse events and stratify the severity of disease in patients with HFpEF. Keywords Myocardial blood flow * Myocardial flow reserve * Cadmium zinc telluride equipped single-photon emission computed tomography camera * Dynamic scanning * Heart failure with preserved ejection fraction * Coronary microvascular dysfunction |
| doi_str_mv | 10.1093/ehjopen/oead028 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A757378628</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A757378628</galeid><sourcerecordid>A757378628</sourcerecordid><originalsourceid>FETCH-LOGICAL-g678-259695d07deb54288b9a08967c21a8e365f88d033279a453662639ca31e74dcf3</originalsourceid><addsrcrecordid>eNptULFqHDEQXUICMY7rtAOu96yVbldSaYydGAxprjPGzEmjWx0raVnpbC6_mp-JLnbhIkwxj8ebN4_XNN87tuqYFlc07tNM8SoRWsbVp-aMy5636053nz_gr81FznvGqoQp3bGz5s9mJJhToVg8TpAc2GPE4A08ah1W-TCvNuapzZRLZbceDNrgDwF--2ig0DQdFm-phezjbqJ2HlNJESj4nH0FJoX5UMhCSSHtFpzHY7UItCBgrq6nMwjHZHCxpwBuSq-wUKblhcBHmLH4mi3Dqy8jjIRLAYe-fqU3an4XW6A9mXL66Rb8B741XxxOmS7e93mzubvd3PxsH379uL-5fmh3g1Qt7_Wge8ukpW2_5kptNdZyBml4h4rE0DulLBOCS43rXgwDH4Q2KDqSa2ucOG8u32x3ONGzjy6VGqAWYJ6vZS-FVANXVbX6j6qOrV2ZFMn5yn84-AtlCpdc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The potential of dynamic [99m.sup.Tc]-sestamibi cadmium zinc telluride- single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction</title><source>DOAJ Directory of Open Access Journals</source><source>Oxford Journals Open Access Collection</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Yoshida, Satoya ; Unno, Kazumasa ; Nanasato, Mamoru ; Niimi, Takanaga ; Inukai, Kohei ; Morisaki, Hidenori ; Hattori, Tomoki ; Hirose, Miku ; Hayashi, Takumi ; Uchida, Noriya ; Simoda, Masahiro ; Oishi, Hideo ; Ando, Monami ; Hirayama, Kenshi ; Takenaka, Masaki ; Maeda, Mayuho ; Yoshida, Ruka ; Ogura, Yasuhiro ; Suzuki, Hirohiko ; Furusawa, Kenji ; Morimoto, Ryota ; Kato, Katsuhiko ; Isobe, Satoshi ; Yoshida, Yukihiko ; Murohara, Toyoaki</creator><creatorcontrib>Yoshida, Satoya ; Unno, Kazumasa ; Nanasato, Mamoru ; Niimi, Takanaga ; Inukai, Kohei ; Morisaki, Hidenori ; Hattori, Tomoki ; Hirose, Miku ; Hayashi, Takumi ; Uchida, Noriya ; Simoda, Masahiro ; Oishi, Hideo ; Ando, Monami ; Hirayama, Kenshi ; Takenaka, Masaki ; Maeda, Mayuho ; Yoshida, Ruka ; Ogura, Yasuhiro ; Suzuki, Hirohiko ; Furusawa, Kenji ; Morimoto, Ryota ; Kato, Katsuhiko ; Isobe, Satoshi ; Yoshida, Yukihiko ; Murohara, Toyoaki</creatorcontrib><description>Aims Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantification of absolute myocardial blood flow and myocardial flow reserve (MFR) in patients with coronary artery disease. However, the potential of CZT- SPECT assessing for CMD has never been evaluated in patients with HFpEF. Methods and results The clinical records of 127 consecutive patients who underwent dynamic CZT-SPECT were retrospectively reviewed. Rest and stress scanning were started simultaneously with 3 and 9 MBq/kg of [99m.sup.Tc]-sestamibi administration, respectively. Dynamic CZT-SPECT imaging data were analysed using a net-retention model with commercially available software. Transthoracic echocardiography was performed in all patients. The MFR value was significantly lower in the HFpEF group (mean [+ or -] SEM = 2.00 [+ or -] 0.097) than that in the non-HFpEF group (mean [+ or -] SEM = 2.74 [+ or -] 0.14, P = 0.0004). A receiver operating characteristic analysis indicated that if a cut-off value of 2.525 was applied, MFR could efficiently distinguish HFpEF from non-HFpEF. Heart failure with preserved ejection fraction had a consistently low MFR, regardless of the diastolic dysfunction score. Heart failure with preserved ejection fraction patients with MFR values lower than 2.075 had a significantly higher incidence of heart failure exacerbation. Conclusion Myocardial flow reserve assessed by CZT-SPECT was significantly reduced in patients with HFpEF. A lower MFR was asso ciated with a higher hospitalization rate in these patients. Myocardial flow reserve assessed by CZT-SPECT has the potential to predict future adverse events and stratify the severity of disease in patients with HFpEF. Keywords Myocardial blood flow * Myocardial flow reserve * Cadmium zinc telluride equipped single-photon emission computed tomography camera * Dynamic scanning * Heart failure with preserved ejection fraction * Coronary microvascular dysfunction</description><identifier>ISSN: 2752-4191</identifier><identifier>EISSN: 2752-4191</identifier><identifier>DOI: 10.1093/ehjopen/oead028</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Development and progression ; Diagnosis ; Heart failure ; Methods ; Patient outcomes ; SPECT imaging ; Zinc compounds</subject><ispartof>European heart journal open, 2023-03, Vol.3 (2)</ispartof><rights>COPYRIGHT 2023 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Yoshida, Satoya</creatorcontrib><creatorcontrib>Unno, Kazumasa</creatorcontrib><creatorcontrib>Nanasato, Mamoru</creatorcontrib><creatorcontrib>Niimi, Takanaga</creatorcontrib><creatorcontrib>Inukai, Kohei</creatorcontrib><creatorcontrib>Morisaki, Hidenori</creatorcontrib><creatorcontrib>Hattori, Tomoki</creatorcontrib><creatorcontrib>Hirose, Miku</creatorcontrib><creatorcontrib>Hayashi, Takumi</creatorcontrib><creatorcontrib>Uchida, Noriya</creatorcontrib><creatorcontrib>Simoda, Masahiro</creatorcontrib><creatorcontrib>Oishi, Hideo</creatorcontrib><creatorcontrib>Ando, Monami</creatorcontrib><creatorcontrib>Hirayama, Kenshi</creatorcontrib><creatorcontrib>Takenaka, Masaki</creatorcontrib><creatorcontrib>Maeda, Mayuho</creatorcontrib><creatorcontrib>Yoshida, Ruka</creatorcontrib><creatorcontrib>Ogura, Yasuhiro</creatorcontrib><creatorcontrib>Suzuki, Hirohiko</creatorcontrib><creatorcontrib>Furusawa, Kenji</creatorcontrib><creatorcontrib>Morimoto, Ryota</creatorcontrib><creatorcontrib>Kato, Katsuhiko</creatorcontrib><creatorcontrib>Isobe, Satoshi</creatorcontrib><creatorcontrib>Yoshida, Yukihiko</creatorcontrib><creatorcontrib>Murohara, Toyoaki</creatorcontrib><title>The potential of dynamic [99m.sup.Tc]-sestamibi cadmium zinc telluride- single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction</title><title>European heart journal open</title><description>Aims Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantification of absolute myocardial blood flow and myocardial flow reserve (MFR) in patients with coronary artery disease. However, the potential of CZT- SPECT assessing for CMD has never been evaluated in patients with HFpEF. Methods and results The clinical records of 127 consecutive patients who underwent dynamic CZT-SPECT were retrospectively reviewed. Rest and stress scanning were started simultaneously with 3 and 9 MBq/kg of [99m.sup.Tc]-sestamibi administration, respectively. Dynamic CZT-SPECT imaging data were analysed using a net-retention model with commercially available software. Transthoracic echocardiography was performed in all patients. The MFR value was significantly lower in the HFpEF group (mean [+ or -] SEM = 2.00 [+ or -] 0.097) than that in the non-HFpEF group (mean [+ or -] SEM = 2.74 [+ or -] 0.14, P = 0.0004). A receiver operating characteristic analysis indicated that if a cut-off value of 2.525 was applied, MFR could efficiently distinguish HFpEF from non-HFpEF. Heart failure with preserved ejection fraction had a consistently low MFR, regardless of the diastolic dysfunction score. Heart failure with preserved ejection fraction patients with MFR values lower than 2.075 had a significantly higher incidence of heart failure exacerbation. Conclusion Myocardial flow reserve assessed by CZT-SPECT was significantly reduced in patients with HFpEF. A lower MFR was asso ciated with a higher hospitalization rate in these patients. Myocardial flow reserve assessed by CZT-SPECT has the potential to predict future adverse events and stratify the severity of disease in patients with HFpEF. Keywords Myocardial blood flow * Myocardial flow reserve * Cadmium zinc telluride equipped single-photon emission computed tomography camera * Dynamic scanning * Heart failure with preserved ejection fraction * Coronary microvascular dysfunction</description><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Heart failure</subject><subject>Methods</subject><subject>Patient outcomes</subject><subject>SPECT imaging</subject><subject>Zinc compounds</subject><issn>2752-4191</issn><issn>2752-4191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptULFqHDEQXUICMY7rtAOu96yVbldSaYydGAxprjPGzEmjWx0raVnpbC6_mp-JLnbhIkwxj8ebN4_XNN87tuqYFlc07tNM8SoRWsbVp-aMy5636053nz_gr81FznvGqoQp3bGz5s9mJJhToVg8TpAc2GPE4A08ah1W-TCvNuapzZRLZbceDNrgDwF--2ig0DQdFm-phezjbqJ2HlNJESj4nH0FJoX5UMhCSSHtFpzHY7UItCBgrq6nMwjHZHCxpwBuSq-wUKblhcBHmLH4mi3Dqy8jjIRLAYe-fqU3an4XW6A9mXL66Rb8B741XxxOmS7e93mzubvd3PxsH379uL-5fmh3g1Qt7_Wge8ukpW2_5kptNdZyBml4h4rE0DulLBOCS43rXgwDH4Q2KDqSa2ucOG8u32x3ONGzjy6VGqAWYJ6vZS-FVANXVbX6j6qOrV2ZFMn5yn84-AtlCpdc</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Yoshida, Satoya</creator><creator>Unno, Kazumasa</creator><creator>Nanasato, Mamoru</creator><creator>Niimi, Takanaga</creator><creator>Inukai, Kohei</creator><creator>Morisaki, Hidenori</creator><creator>Hattori, Tomoki</creator><creator>Hirose, Miku</creator><creator>Hayashi, Takumi</creator><creator>Uchida, Noriya</creator><creator>Simoda, Masahiro</creator><creator>Oishi, Hideo</creator><creator>Ando, Monami</creator><creator>Hirayama, Kenshi</creator><creator>Takenaka, Masaki</creator><creator>Maeda, Mayuho</creator><creator>Yoshida, Ruka</creator><creator>Ogura, Yasuhiro</creator><creator>Suzuki, Hirohiko</creator><creator>Furusawa, Kenji</creator><creator>Morimoto, Ryota</creator><creator>Kato, Katsuhiko</creator><creator>Isobe, Satoshi</creator><creator>Yoshida, Yukihiko</creator><creator>Murohara, Toyoaki</creator><general>Oxford University Press</general><scope/></search><sort><creationdate>20230301</creationdate><title>The potential of dynamic [99m.sup.Tc]-sestamibi cadmium zinc telluride- single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction</title><author>Yoshida, Satoya ; Unno, Kazumasa ; Nanasato, Mamoru ; Niimi, Takanaga ; Inukai, Kohei ; Morisaki, Hidenori ; Hattori, Tomoki ; Hirose, Miku ; Hayashi, Takumi ; Uchida, Noriya ; Simoda, Masahiro ; Oishi, Hideo ; Ando, Monami ; Hirayama, Kenshi ; Takenaka, Masaki ; Maeda, Mayuho ; Yoshida, Ruka ; Ogura, Yasuhiro ; Suzuki, Hirohiko ; Furusawa, Kenji ; Morimoto, Ryota ; Kato, Katsuhiko ; Isobe, Satoshi ; Yoshida, Yukihiko ; Murohara, Toyoaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g678-259695d07deb54288b9a08967c21a8e365f88d033279a453662639ca31e74dcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Heart failure</topic><topic>Methods</topic><topic>Patient outcomes</topic><topic>SPECT imaging</topic><topic>Zinc compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, Satoya</creatorcontrib><creatorcontrib>Unno, Kazumasa</creatorcontrib><creatorcontrib>Nanasato, Mamoru</creatorcontrib><creatorcontrib>Niimi, Takanaga</creatorcontrib><creatorcontrib>Inukai, Kohei</creatorcontrib><creatorcontrib>Morisaki, Hidenori</creatorcontrib><creatorcontrib>Hattori, Tomoki</creatorcontrib><creatorcontrib>Hirose, Miku</creatorcontrib><creatorcontrib>Hayashi, Takumi</creatorcontrib><creatorcontrib>Uchida, Noriya</creatorcontrib><creatorcontrib>Simoda, Masahiro</creatorcontrib><creatorcontrib>Oishi, Hideo</creatorcontrib><creatorcontrib>Ando, Monami</creatorcontrib><creatorcontrib>Hirayama, Kenshi</creatorcontrib><creatorcontrib>Takenaka, Masaki</creatorcontrib><creatorcontrib>Maeda, Mayuho</creatorcontrib><creatorcontrib>Yoshida, Ruka</creatorcontrib><creatorcontrib>Ogura, Yasuhiro</creatorcontrib><creatorcontrib>Suzuki, Hirohiko</creatorcontrib><creatorcontrib>Furusawa, Kenji</creatorcontrib><creatorcontrib>Morimoto, Ryota</creatorcontrib><creatorcontrib>Kato, Katsuhiko</creatorcontrib><creatorcontrib>Isobe, Satoshi</creatorcontrib><creatorcontrib>Yoshida, Yukihiko</creatorcontrib><creatorcontrib>Murohara, Toyoaki</creatorcontrib><jtitle>European heart journal open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, Satoya</au><au>Unno, Kazumasa</au><au>Nanasato, Mamoru</au><au>Niimi, Takanaga</au><au>Inukai, Kohei</au><au>Morisaki, Hidenori</au><au>Hattori, Tomoki</au><au>Hirose, Miku</au><au>Hayashi, Takumi</au><au>Uchida, Noriya</au><au>Simoda, Masahiro</au><au>Oishi, Hideo</au><au>Ando, Monami</au><au>Hirayama, Kenshi</au><au>Takenaka, Masaki</au><au>Maeda, Mayuho</au><au>Yoshida, Ruka</au><au>Ogura, Yasuhiro</au><au>Suzuki, Hirohiko</au><au>Furusawa, Kenji</au><au>Morimoto, Ryota</au><au>Kato, Katsuhiko</au><au>Isobe, Satoshi</au><au>Yoshida, Yukihiko</au><au>Murohara, Toyoaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The potential of dynamic [99m.sup.Tc]-sestamibi cadmium zinc telluride- single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction</atitle><jtitle>European heart journal open</jtitle><date>2023-03-01</date><risdate>2023</risdate><volume>3</volume><issue>2</issue><issn>2752-4191</issn><eissn>2752-4191</eissn><abstract>Aims Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantification of absolute myocardial blood flow and myocardial flow reserve (MFR) in patients with coronary artery disease. However, the potential of CZT- SPECT assessing for CMD has never been evaluated in patients with HFpEF. Methods and results The clinical records of 127 consecutive patients who underwent dynamic CZT-SPECT were retrospectively reviewed. Rest and stress scanning were started simultaneously with 3 and 9 MBq/kg of [99m.sup.Tc]-sestamibi administration, respectively. Dynamic CZT-SPECT imaging data were analysed using a net-retention model with commercially available software. Transthoracic echocardiography was performed in all patients. The MFR value was significantly lower in the HFpEF group (mean [+ or -] SEM = 2.00 [+ or -] 0.097) than that in the non-HFpEF group (mean [+ or -] SEM = 2.74 [+ or -] 0.14, P = 0.0004). A receiver operating characteristic analysis indicated that if a cut-off value of 2.525 was applied, MFR could efficiently distinguish HFpEF from non-HFpEF. Heart failure with preserved ejection fraction had a consistently low MFR, regardless of the diastolic dysfunction score. Heart failure with preserved ejection fraction patients with MFR values lower than 2.075 had a significantly higher incidence of heart failure exacerbation. Conclusion Myocardial flow reserve assessed by CZT-SPECT was significantly reduced in patients with HFpEF. A lower MFR was asso ciated with a higher hospitalization rate in these patients. Myocardial flow reserve assessed by CZT-SPECT has the potential to predict future adverse events and stratify the severity of disease in patients with HFpEF. Keywords Myocardial blood flow * Myocardial flow reserve * Cadmium zinc telluride equipped single-photon emission computed tomography camera * Dynamic scanning * Heart failure with preserved ejection fraction * Coronary microvascular dysfunction</abstract><pub>Oxford University Press</pub><doi>10.1093/ehjopen/oead028</doi></addata></record> |
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| subjects | Development and progression Diagnosis Heart failure Methods Patient outcomes SPECT imaging Zinc compounds |
| title | The potential of dynamic [99m.sup.Tc]-sestamibi cadmium zinc telluride- single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction |
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