Discovery of Gemcitabine Derivatives as Potent Inhibitors Against Drug-Resistant Bacteria with Decreased Toxicity Profiles

The rapid emergence of antimicrobial resistance represents a major public health threaten, which necessitates the discovery of novel antibacterial agents. In this study, four gemcitabine derivatives were synthesized by introduction of aromatic substituents at the amine group. Then, the derivates wer...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2023-06, Vol.57 (3), p.401-407
Hauptverfasser:	Wang, Xiao-Xiao, Tang, Zong-Wei, Zeng, Jin, Chen, Wan-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Drug resistance in microorganisms Gemcitabine Medicine Methicillin Organic Chemistry Pharmacology/Toxicology Pharmacy Staphylococcus aureus
Online-Zugang:	Volltext
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