Enhancing the Catalytic Activity of Thermo-Asparaginase from IThermococcus sibiricus/I by a Double Mesophilic-like Mutation in the Substrate-Binding Region

L-asparaginases (L-ASNases) of microbial origin are the mainstay of blood cancer treatment. Numerous attempts have been performed for genetic improvement of the main properties of these enzymes. The substrate-binding Ser residue is highly conserved in L-ASNases regardless of their origin or type. Ho...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (11)
Hauptverfasser:	Dumina, Maria, Zhdanov, Dmitry, Zhgun, Alexander, Pokrovskaya, Marina, Aleksandrova, Svetlana, Veselovsky, Alexander, El’darov, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Asparaginase Asparagine Aspartate Genetic aspects Scientific equipment and supplies industry
Online-Zugang:	Volltext
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