IADAM10/I Gene Variants in AD Patients and Their Relationship to CSF Protein Levels

ADAM10 is the main α-secretase acting in the non-amyloidogenic processing of APP. We hypothesized that certain rare ADAM10 variants could increase the risk for AD by conferring the age-related downregulation of α-secretase. The ADAM10 gene was sequenced in 103 AD cases (82% familial) and 96 cognitiv...

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Veröffentlicht in:	International journal of molecular sciences 2023-03, Vol.24 (7)
Hauptverfasser:	Agüero-Rabes, Pablo, Pérez-Pérez, Julián, Cremades-Jimeno, Lucía, García-Ayllón, María-Salud, Gea-González, Adriana, Sainz, María José, Mahillo-Fernández, Ignacio, Téllez, Raquel, Cárdaba, Blanca, Sáez-Valero, Javier, Gómez-Tortosa, Estrella
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Analysis Apolipoproteins Genes
Online-Zugang:	Volltext
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