The Potential Chemopreventive Effect of IAndrographis paniculata/I on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats

Colorectal cancer (CRC) is responsible for a notable rise in the overall mortality rate. Obesity is found to be one of the main factors behind CRC development. Andrographis paniculata is a herbaceous plant famous for its medicinal properties, particularly in Southeast Asia for its anti-cancer proper...

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Veröffentlicht in:International journal of molecular sciences 2023-03, Vol.24 (6)
Hauptverfasser: Subarmaniam, Tharani, Mahmad Rusli, Rusydatul Nabila, Perumal, Kokila Vani, Yong, Yoke Keong, Hadizah, Siti, Othman, Fezah, Salem, Khaled, Shafie, Nurul Husna, Hasham, Rosnani, Yin, Khoo Boon, Abdul Kadir, Khairul Kamilah, Bahari, Hasnah, Zakaria, Zainul Amiruddin
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container_issue 6
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container_title International journal of molecular sciences
container_volume 24
creator Subarmaniam, Tharani
Mahmad Rusli, Rusydatul Nabila
Perumal, Kokila Vani
Yong, Yoke Keong
Hadizah, Siti
Othman, Fezah
Salem, Khaled
Shafie, Nurul Husna
Hasham, Rosnani
Yin, Khoo Boon
Abdul Kadir, Khairul Kamilah
Bahari, Hasnah
Zakaria, Zainul Amiruddin
description Colorectal cancer (CRC) is responsible for a notable rise in the overall mortality rate. Obesity is found to be one of the main factors behind CRC development. Andrographis paniculata is a herbaceous plant famous for its medicinal properties, particularly in Southeast Asia for its anti-cancer properties. This study examines the chemopreventive impact of A. paniculata ethanolic extract (APEE) against a high-fat diet and 1,2-dimethylhydrazine-induced colon cancer in Sprague Dawley rats. Sprague Dawley rats were administered 1,2-dimethylhydrazine (40 mg/kg, i.p. once a week for 10 weeks) and a high-fat diet (HFD) for 20 weeks to induce colorectal cancer. APEE was administered at 125 mg/kg, 250 mg/kg, and 500 mg/kg for 20 weeks. At the end of the experiment, blood serum and organs were collected. DMH/HFD-induced rats had abnormal crypts and more aberrant crypt foci (ACF). APEE at a dose of 500 mg/kg improved the dysplastic state of the colon tissue and caused a 32% reduction in the total ACF. HFD increased adipocyte cell size, while 500 mg/kg APEE reduced it. HFD and DMH/HFD rats had elevated serum insulin and leptin levels. Moreover, UHPLC-QTOF-MS analysis revealed that APEE was rich in anti-cancer phytochemicals. This finding suggests that APEE has anti-cancer potential against HFD/DMH-induced CRC and anti-adipogenic and anti-obesity properties.
doi_str_mv 10.3390/ijms24065224
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source MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Biological products
Cancer
Care and treatment
Colorectal cancer
Diet
Health aspects
Leptin
Medicine, Botanic
Medicine, Herbal
Oncology, Experimental
Prevention
title The Potential Chemopreventive Effect of IAndrographis paniculata/I on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats
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