Secondary Metabolites of Oplopanax elatus: Possibilities for Standardization of a Multiphytoadaptogen for Preventive Oncology
An herbal formulation of a multiphytoadaptogen (MPA) developed at the N. N. Blokhin Cancer Center and containing phytocomponents from Oplopanax elatus Nakai has been studied in preclinical and clinical trials for preventive oncology. Secondary metabolites were identified in the extract of rhizomes a...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2023-04, Vol.57 (1), p.75-82 |
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| creator | Kazeev, I. V. Ionov, N. S. Shevchenko, V. E. Bocharov, E. V. Karpova, R. V. Aksenov, A. A. Sheichenko, O. P. Kucheryanu, V. G. Kosorukov, V. S. Filmonov, D. A. Lagunin, A. A. Poroikov, V. V. Pyatigorskaya, N. V. Bocharova, O. A. |
| description | An herbal formulation of a multiphytoadaptogen (MPA) developed at the N. N. Blokhin Cancer Center and containing phytocomponents from
Oplopanax elatus
Nakai has been studied in preclinical and clinical trials for preventive oncology. Secondary metabolites were identified in the extract of rhizomes and roots of
O. elatus
and in the MPA pharmaceutical composition using high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Compounds identical to ginsenosides Rd and Re (tetracyclic triterpene saponins from
Panax ginseng
) and araloside C and stipuleanoside R2 (pentacyclic triterpene saponins, oleanolic acid derivatives, from
Aralia mandshurica
) were identified in the MPA and in the extract of rhizomes and roots of
O. elatus
. The spectra of biological activity of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 were analyzed
in silico
using the PASS computer program. According to published data and
in silico
analysis, the activities of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 correspond to properties previously confirmed in the MPA studies for preventive oncology. |
| doi_str_mv | 10.1007/s11094-023-02853-w |
| format | Article |
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Oplopanax elatus
Nakai has been studied in preclinical and clinical trials for preventive oncology. Secondary metabolites were identified in the extract of rhizomes and roots of
O. elatus
and in the MPA pharmaceutical composition using high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Compounds identical to ginsenosides Rd and Re (tetracyclic triterpene saponins from
Panax ginseng
) and araloside C and stipuleanoside R2 (pentacyclic triterpene saponins, oleanolic acid derivatives, from
Aralia mandshurica
) were identified in the MPA and in the extract of rhizomes and roots of
O. elatus
. The spectra of biological activity of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 were analyzed
in silico
using the PASS computer program. According to published data and
in silico
analysis, the activities of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 correspond to properties previously confirmed in the MPA studies for preventive oncology.</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-023-02853-w</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; High performance liquid chromatography ; Mass spectrometry ; Medical research ; Medicine ; Medicine, Experimental ; Organic Chemistry ; Pharmacology/Toxicology ; Pharmacy ; Plant metabolites ; Saponins</subject><ispartof>Pharmaceutical chemistry journal, 2023-04, Vol.57 (1), p.75-82</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-b1528fb11517791267fc9be02e715b5f44933f6f698af95fc6fdc0e79b5f90ea3</citedby><cites>FETCH-LOGICAL-c358t-b1528fb11517791267fc9be02e715b5f44933f6f698af95fc6fdc0e79b5f90ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11094-023-02853-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11094-023-02853-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids></links><search><creatorcontrib>Kazeev, I. V.</creatorcontrib><creatorcontrib>Ionov, N. S.</creatorcontrib><creatorcontrib>Shevchenko, V. E.</creatorcontrib><creatorcontrib>Bocharov, E. V.</creatorcontrib><creatorcontrib>Karpova, R. V.</creatorcontrib><creatorcontrib>Aksenov, A. A.</creatorcontrib><creatorcontrib>Sheichenko, O. P.</creatorcontrib><creatorcontrib>Kucheryanu, V. G.</creatorcontrib><creatorcontrib>Kosorukov, V. S.</creatorcontrib><creatorcontrib>Filmonov, D. A.</creatorcontrib><creatorcontrib>Lagunin, A. A.</creatorcontrib><creatorcontrib>Poroikov, V. V.</creatorcontrib><creatorcontrib>Pyatigorskaya, N. V.</creatorcontrib><creatorcontrib>Bocharova, O. A.</creatorcontrib><title>Secondary Metabolites of Oplopanax elatus: Possibilities for Standardization of a Multiphytoadaptogen for Preventive Oncology</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><description>An herbal formulation of a multiphytoadaptogen (MPA) developed at the N. N. Blokhin Cancer Center and containing phytocomponents from
Oplopanax elatus
Nakai has been studied in preclinical and clinical trials for preventive oncology. Secondary metabolites were identified in the extract of rhizomes and roots of
O. elatus
and in the MPA pharmaceutical composition using high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Compounds identical to ginsenosides Rd and Re (tetracyclic triterpene saponins from
Panax ginseng
) and araloside C and stipuleanoside R2 (pentacyclic triterpene saponins, oleanolic acid derivatives, from
Aralia mandshurica
) were identified in the MPA and in the extract of rhizomes and roots of
O. elatus
. The spectra of biological activity of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 were analyzed
in silico
using the PASS computer program. According to published data and
in silico
analysis, the activities of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 correspond to properties previously confirmed in the MPA studies for preventive oncology.</description><subject>Analysis</subject><subject>High performance liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine, Experimental</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant metabolites</subject><subject>Saponins</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kVtLwzAYhoMoOA9_wKuC151Js7SNdzI8gbLBFLwLafplRrqkJNl0gv_dbPNGEAkhkDzPB3lfhM4IHhKMq4tACOajHBc07ZrR_H0PDQiraM4xJftogDEnOWH45RAdhfCGcdJoMUBfM1DOttKvs0eIsnGdiRAyp7NJ37leWvmRQSfjMlxmUxeCaUwiTEK089ksyo3bmk8ZjbMbTWaPyy6a_nUdnWxlH90c7BaeeliBjWYF2cQq17n5-gQdaNkFOP05j9HzzfXT-C5_mNzej68eckVZHfOGsKLWDSGMVBUnRVlpxRvABVSENUyPRpxSXeqS11JzplWpW4Wh4umNY5D0GJ3v5s5lB8JY7aKXamGCElfVqCaMsbJM1PAPKq0WFialBNqk-19CsROUT9F40KL3ZpGyFASLTS9i14tIvYhtL-I9SXQnhQTbOXjx5pbepu__Z30DZWiTaw</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Kazeev, I. V.</creator><creator>Ionov, N. S.</creator><creator>Shevchenko, V. E.</creator><creator>Bocharov, E. V.</creator><creator>Karpova, R. V.</creator><creator>Aksenov, A. A.</creator><creator>Sheichenko, O. P.</creator><creator>Kucheryanu, V. G.</creator><creator>Kosorukov, V. S.</creator><creator>Filmonov, D. A.</creator><creator>Lagunin, A. A.</creator><creator>Poroikov, V. V.</creator><creator>Pyatigorskaya, N. V.</creator><creator>Bocharova, O. A.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230401</creationdate><title>Secondary Metabolites of Oplopanax elatus: Possibilities for Standardization of a Multiphytoadaptogen for Preventive Oncology</title><author>Kazeev, I. V. ; Ionov, N. S. ; Shevchenko, V. E. ; Bocharov, E. V. ; Karpova, R. V. ; Aksenov, A. A. ; Sheichenko, O. P. ; Kucheryanu, V. G. ; Kosorukov, V. S. ; Filmonov, D. A. ; Lagunin, A. A. ; Poroikov, V. V. ; Pyatigorskaya, N. V. ; Bocharova, O. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-b1528fb11517791267fc9be02e715b5f44933f6f698af95fc6fdc0e79b5f90ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>High performance liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine, Experimental</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant metabolites</topic><topic>Saponins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazeev, I. V.</creatorcontrib><creatorcontrib>Ionov, N. S.</creatorcontrib><creatorcontrib>Shevchenko, V. E.</creatorcontrib><creatorcontrib>Bocharov, E. V.</creatorcontrib><creatorcontrib>Karpova, R. V.</creatorcontrib><creatorcontrib>Aksenov, A. A.</creatorcontrib><creatorcontrib>Sheichenko, O. P.</creatorcontrib><creatorcontrib>Kucheryanu, V. G.</creatorcontrib><creatorcontrib>Kosorukov, V. S.</creatorcontrib><creatorcontrib>Filmonov, D. A.</creatorcontrib><creatorcontrib>Lagunin, A. A.</creatorcontrib><creatorcontrib>Poroikov, V. V.</creatorcontrib><creatorcontrib>Pyatigorskaya, N. V.</creatorcontrib><creatorcontrib>Bocharova, O. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazeev, I. V.</au><au>Ionov, N. S.</au><au>Shevchenko, V. E.</au><au>Bocharov, E. V.</au><au>Karpova, R. V.</au><au>Aksenov, A. A.</au><au>Sheichenko, O. P.</au><au>Kucheryanu, V. G.</au><au>Kosorukov, V. S.</au><au>Filmonov, D. A.</au><au>Lagunin, A. A.</au><au>Poroikov, V. V.</au><au>Pyatigorskaya, N. V.</au><au>Bocharova, O. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary Metabolites of Oplopanax elatus: Possibilities for Standardization of a Multiphytoadaptogen for Preventive Oncology</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2023-04-01</date><risdate>2023</risdate><volume>57</volume><issue>1</issue><spage>75</spage><epage>82</epage><pages>75-82</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>An herbal formulation of a multiphytoadaptogen (MPA) developed at the N. N. Blokhin Cancer Center and containing phytocomponents from
Oplopanax elatus
Nakai has been studied in preclinical and clinical trials for preventive oncology. Secondary metabolites were identified in the extract of rhizomes and roots of
O. elatus
and in the MPA pharmaceutical composition using high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Compounds identical to ginsenosides Rd and Re (tetracyclic triterpene saponins from
Panax ginseng
) and araloside C and stipuleanoside R2 (pentacyclic triterpene saponins, oleanolic acid derivatives, from
Aralia mandshurica
) were identified in the MPA and in the extract of rhizomes and roots of
O. elatus
. The spectra of biological activity of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 were analyzed
in silico
using the PASS computer program. According to published data and
in silico
analysis, the activities of ginsenosides Rd and Re, araloside C, and stipuleanoside R2 correspond to properties previously confirmed in the MPA studies for preventive oncology.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-023-02853-w</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis High performance liquid chromatography Mass spectrometry Medical research Medicine Medicine, Experimental Organic Chemistry Pharmacology/Toxicology Pharmacy Plant metabolites Saponins |
| title | Secondary Metabolites of Oplopanax elatus: Possibilities for Standardization of a Multiphytoadaptogen for Preventive Oncology |
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