Serotype distribution, trend of multidrug resistance and prevalence of [beta]-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China
Salmonella, one of the major causes of foodborne infections, can cause bacterial foodborne illness. We investigated the serotype distribution, multidrug resistance (MDR), and [beta]-lactamase resistance genes of human Salmonella isolates collected from clinical specimens in Guizhou, China, between 2...
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| Veröffentlicht in: | PloS one 2023-04, Vol.18 (4), p.e0282254 |
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| description | Salmonella, one of the major causes of foodborne infections, can cause bacterial foodborne illness. We investigated the serotype distribution, multidrug resistance (MDR), and [beta]-lactamase resistance genes of human Salmonella isolates collected from clinical specimens in Guizhou, China, between 2013 and 2018. A total of 363 Salmonella isolates were collected from clinical specimens at 17 surveillance hospitals. Twenty-four serotypes were identified by sliding agglutination test. S. Enteritidis (33.9%), Salmonella 4,[5],12:i:- (24.0%), S. Typhimurium (16.3%), S. London (6.3%), and S. Derby (3.9%) were the top five serotypes. In 2018, the most common serotype changed from S. Enteritidis to S. Typhimurium. Among the 363 Salmonella isolates, 97.5% of isolates were resistant to at least one class of antimicrobial agents. For cephalosporins, ceftriaxone had the highest resistance rate of 10.5%, and cefepime and cefoxitin were 8.0% and 2.2%, respectively. Three hundred and one (82.9%) Salmonella isolates showed MDR. Salmonella 4,[5],12:i:- had the highest MDR rate with 94.2%, followed by S. London (91.3%) and S. Typhimurium (88.1%). Multidrug resistance rates of Salmonella isolates in Guizhou from 2013 to 2017 increased from 75.8% to 86.7%. Sixteen isolates (4.4%) showed extensive drug resistance. One hundred thirty-four antimicrobial resistance patterns were found. Two hundred and forty-one (66.4%) isolates carried at least one [beta]-lactamase resistance gene. The bla.sub.TEM gene (61.2%) was the most prevalent resistant gene in all Salmonella isolates, followed by the bla.sub.CTX-M gene (6.1%) and bla.sub.OXA-1 gene (4.1%). Our findings showed that the MDR rate of Salmonella isolates from Guizhou province increased year by year. Therefore, systematic and long-term surveillance on MDR Salmonella isolates from clinical patients should be further strengthened. |
| doi_str_mv | 10.1371/journal.pone.0282254 |
| format | Article |
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We investigated the serotype distribution, multidrug resistance (MDR), and [beta]-lactamase resistance genes of human Salmonella isolates collected from clinical specimens in Guizhou, China, between 2013 and 2018. A total of 363 Salmonella isolates were collected from clinical specimens at 17 surveillance hospitals. Twenty-four serotypes were identified by sliding agglutination test. S. Enteritidis (33.9%), Salmonella 4,[5],12:i:- (24.0%), S. Typhimurium (16.3%), S. London (6.3%), and S. Derby (3.9%) were the top five serotypes. In 2018, the most common serotype changed from S. Enteritidis to S. Typhimurium. Among the 363 Salmonella isolates, 97.5% of isolates were resistant to at least one class of antimicrobial agents. For cephalosporins, ceftriaxone had the highest resistance rate of 10.5%, and cefepime and cefoxitin were 8.0% and 2.2%, respectively. Three hundred and one (82.9%) Salmonella isolates showed MDR. Salmonella 4,[5],12:i:- had the highest MDR rate with 94.2%, followed by S. London (91.3%) and S. Typhimurium (88.1%). Multidrug resistance rates of Salmonella isolates in Guizhou from 2013 to 2017 increased from 75.8% to 86.7%. Sixteen isolates (4.4%) showed extensive drug resistance. One hundred thirty-four antimicrobial resistance patterns were found. Two hundred and forty-one (66.4%) isolates carried at least one [beta]-lactamase resistance gene. The bla.sub.TEM gene (61.2%) was the most prevalent resistant gene in all Salmonella isolates, followed by the bla.sub.CTX-M gene (6.1%) and bla.sub.OXA-1 gene (4.1%). Our findings showed that the MDR rate of Salmonella isolates from Guizhou province increased year by year. Therefore, systematic and long-term surveillance on MDR Salmonella isolates from clinical patients should be further strengthened.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0282254</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Care and treatment ; Diagnosis ; Distribution ; Drug resistance in microorganisms ; Salmonellosis</subject><ispartof>PloS one, 2023-04, Vol.18 (4), p.e0282254</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Wei, Xiaoyu</creatorcontrib><creatorcontrib>Long, Li</creatorcontrib><creatorcontrib>You, Lv</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Liu, Chunting</creatorcontrib><creatorcontrib>Li, Shijun</creatorcontrib><creatorcontrib>Wang, Junhua</creatorcontrib><title>Serotype distribution, trend of multidrug resistance and prevalence of [beta]-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China</title><title>PloS one</title><description>Salmonella, one of the major causes of foodborne infections, can cause bacterial foodborne illness. We investigated the serotype distribution, multidrug resistance (MDR), and [beta]-lactamase resistance genes of human Salmonella isolates collected from clinical specimens in Guizhou, China, between 2013 and 2018. A total of 363 Salmonella isolates were collected from clinical specimens at 17 surveillance hospitals. Twenty-four serotypes were identified by sliding agglutination test. S. Enteritidis (33.9%), Salmonella 4,[5],12:i:- (24.0%), S. Typhimurium (16.3%), S. London (6.3%), and S. Derby (3.9%) were the top five serotypes. In 2018, the most common serotype changed from S. Enteritidis to S. Typhimurium. Among the 363 Salmonella isolates, 97.5% of isolates were resistant to at least one class of antimicrobial agents. For cephalosporins, ceftriaxone had the highest resistance rate of 10.5%, and cefepime and cefoxitin were 8.0% and 2.2%, respectively. Three hundred and one (82.9%) Salmonella isolates showed MDR. Salmonella 4,[5],12:i:- had the highest MDR rate with 94.2%, followed by S. London (91.3%) and S. Typhimurium (88.1%). Multidrug resistance rates of Salmonella isolates in Guizhou from 2013 to 2017 increased from 75.8% to 86.7%. Sixteen isolates (4.4%) showed extensive drug resistance. One hundred thirty-four antimicrobial resistance patterns were found. Two hundred and forty-one (66.4%) isolates carried at least one [beta]-lactamase resistance gene. The bla.sub.TEM gene (61.2%) was the most prevalent resistant gene in all Salmonella isolates, followed by the bla.sub.CTX-M gene (6.1%) and bla.sub.OXA-1 gene (4.1%). Our findings showed that the MDR rate of Salmonella isolates from Guizhou province increased year by year. Therefore, systematic and long-term surveillance on MDR Salmonella isolates from clinical patients should be further strengthened.</description><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Distribution</subject><subject>Drug resistance in microorganisms</subject><subject>Salmonellosis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkdFq2zAUhsVYYV26N-iFYDAYxJlkx7J9WULbBQqBpe3NKOFEPrJVZClIcun2Un3Fam0vEthF0YWk83-_OOcXIaeczXhR8R_3bvQWzGznLM5YXud5Of9AjnlT5JnIWfFx7_yJfA7hnrGyqIU4Jk9r9C7-2SFtdYheb8eonZ3S6NG21Ck6jCbq1o8d9RgSAlYihaTtPD6AwX_XhP3eYoS7zICMMEDAfbpDi4FqS_txAEvXYIbUqDFAdXAGYhKVdwOVRlstwdCwQ6kHtC-my1H_7d04pYteWzghRwpMwC9v-4TcXJxfL35mV6vL5eLsKuu4EGWGdV2WnEnF5sglyiKvt6pgogLWiDrHJNSq5EK2OZNN0xbQlNuqxbmqGtYoWUzI19d3uzTjRlvlogc56CA3Z9VcpNR5inBCZv-h0mpx0DINqXSqHxi-HxgSE_ExdjCGsFmuf72fXd0est_22B7BxD5l-_KZYR98Bk7ysCg</recordid><startdate>20230420</startdate><enddate>20230420</enddate><creator>Wei, Xiaoyu</creator><creator>Long, Li</creator><creator>You, Lv</creator><creator>Wang, Ming</creator><creator>Wang, Dan</creator><creator>Liu, Chunting</creator><creator>Li, Shijun</creator><creator>Wang, Junhua</creator><general>Public Library of Science</general><scope>IOV</scope><scope>ISR</scope></search><sort><creationdate>20230420</creationdate><title>Serotype distribution, trend of multidrug resistance and prevalence of [beta]-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China</title><author>Wei, Xiaoyu ; Long, Li ; You, Lv ; Wang, Ming ; Wang, Dan ; Liu, Chunting ; Li, Shijun ; Wang, Junhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1665-e885510cf04e1cec328bf3067a09682ecf08f516cd20c99d3a95b7de4f7909fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Distribution</topic><topic>Drug resistance in microorganisms</topic><topic>Salmonellosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Xiaoyu</creatorcontrib><creatorcontrib>Long, Li</creatorcontrib><creatorcontrib>You, Lv</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Liu, Chunting</creatorcontrib><creatorcontrib>Li, Shijun</creatorcontrib><creatorcontrib>Wang, Junhua</creatorcontrib><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Xiaoyu</au><au>Long, Li</au><au>You, Lv</au><au>Wang, Ming</au><au>Wang, Dan</au><au>Liu, Chunting</au><au>Li, Shijun</au><au>Wang, Junhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotype distribution, trend of multidrug resistance and prevalence of [beta]-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China</atitle><jtitle>PloS one</jtitle><date>2023-04-20</date><risdate>2023</risdate><volume>18</volume><issue>4</issue><spage>e0282254</spage><pages>e0282254-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Salmonella, one of the major causes of foodborne infections, can cause bacterial foodborne illness. We investigated the serotype distribution, multidrug resistance (MDR), and [beta]-lactamase resistance genes of human Salmonella isolates collected from clinical specimens in Guizhou, China, between 2013 and 2018. A total of 363 Salmonella isolates were collected from clinical specimens at 17 surveillance hospitals. Twenty-four serotypes were identified by sliding agglutination test. S. Enteritidis (33.9%), Salmonella 4,[5],12:i:- (24.0%), S. Typhimurium (16.3%), S. London (6.3%), and S. Derby (3.9%) were the top five serotypes. In 2018, the most common serotype changed from S. Enteritidis to S. Typhimurium. Among the 363 Salmonella isolates, 97.5% of isolates were resistant to at least one class of antimicrobial agents. For cephalosporins, ceftriaxone had the highest resistance rate of 10.5%, and cefepime and cefoxitin were 8.0% and 2.2%, respectively. Three hundred and one (82.9%) Salmonella isolates showed MDR. Salmonella 4,[5],12:i:- had the highest MDR rate with 94.2%, followed by S. London (91.3%) and S. Typhimurium (88.1%). Multidrug resistance rates of Salmonella isolates in Guizhou from 2013 to 2017 increased from 75.8% to 86.7%. Sixteen isolates (4.4%) showed extensive drug resistance. One hundred thirty-four antimicrobial resistance patterns were found. Two hundred and forty-one (66.4%) isolates carried at least one [beta]-lactamase resistance gene. The bla.sub.TEM gene (61.2%) was the most prevalent resistant gene in all Salmonella isolates, followed by the bla.sub.CTX-M gene (6.1%) and bla.sub.OXA-1 gene (4.1%). Our findings showed that the MDR rate of Salmonella isolates from Guizhou province increased year by year. Therefore, systematic and long-term surveillance on MDR Salmonella isolates from clinical patients should be further strengthened.</abstract><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0282254</doi><tpages>e0282254</tpages></addata></record> |
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| subjects | Care and treatment Diagnosis Distribution Drug resistance in microorganisms Salmonellosis |
| title | Serotype distribution, trend of multidrug resistance and prevalence of [beta]-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China |
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