Recent Advances on Natural Aryl-IC/I-glycoside Scaffolds: Structure, Bioactivities, and Synthesis—A Comprehensive Review
Aryl-C-glycosides, of both synthetic and natural origin, are of great significance in medicinal chemistry owing to their unique structures and stability towards enzymatic and chemical hydrolysis as compared to O-glycosides. They are well-known antibiotics and potent enzyme inhibitors and possess a w...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (21) |
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| container_title | Molecules (Basel, Switzerland) |
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| creator | Liu, Chen-Fu |
| description | Aryl-C-glycosides, of both synthetic and natural origin, are of great significance in medicinal chemistry owing to their unique structures and stability towards enzymatic and chemical hydrolysis as compared to O-glycosides. They are well-known antibiotics and potent enzyme inhibitors and possess a wide range of biological activities such as anticancer, antioxidant, antiviral, hypoglycemic effects, and so on. Currently, a number of aryl-C-glycoside drugs are on sale for the treatment of diabetes and related complications. This review summarizes the findings on aryl-C-glycoside scaffolds over the past 20 years, concerning new structures (over 200 molecules), their bioactivities—including anticancer, anti-inflammatory, antioxidant, antivirus, glycation inhibitory activities and other pharmacological effects—as well as their synthesis. |
| doi_str_mv | 10.3390/molecules27217439 |
| format | Article |
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They are well-known antibiotics and potent enzyme inhibitors and possess a wide range of biological activities such as anticancer, antioxidant, antiviral, hypoglycemic effects, and so on. Currently, a number of aryl-C-glycoside drugs are on sale for the treatment of diabetes and related complications. 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| source | DOAJ Directory of Open Access Journals; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anti-infective agents Antimitotic agents Antineoplastic agents Chemical properties Chemical structure Enzyme inhibitors Health aspects Materia medica, Vegetable Organic compounds Pharmaceutical research Plant extracts |
| title | Recent Advances on Natural Aryl-IC/I-glycoside Scaffolds: Structure, Bioactivities, and Synthesis—A Comprehensive Review |
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