ICYP2C9/I Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid

Polymorphisms in CYP2C9 can significantly interfere with the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen. The present research aimed to study the PK/PD parameters of naproxen and its metabolite, 6-O-desmethylnaproxen,...

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Veröffentlicht in:	Metabolites 2022-11, Vol.12 (11)
Hauptverfasser:	Oliveira, Gabriela Moraes, Dionísio, Thiago José, Siqueira-Sandrin, Viviane Silva, Ferrari, Leticia Alves de Lima, Bolani, Bruna, Parisi, Viviane Aparecida, Polanco, Nelson Leonel Del Hierro, Colombini-Ishikiriama, Bella Luna, Faria, Flávio Augusto Cardoso, Santos, Carlos Ferreira, Calvo, Adriana Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Complications and side effects Cytochrome P-450 Genetic polymorphisms Metabolites Naproxen Patient outcomes
Online-Zugang:	Volltext
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