Structure/Function Studies on the Activation Motif of Two Non-Mammalian Mrap1 Orthologs, and Observations on the Phylogeny of Mrap1, Including a Novel Characterization of an Mrap1 from the Chondrostean Fish, IPolyodon spathula/I

In derived bony vertebrates, activation of the melanocortin-2 receptor (Mc2r) by its ACTH ligand requires chaperoning by the Mc2r accessory protein (Mrap1). The N-terminal domain of the non-mammalian tetrapod MRAP1 from chicken (c; Gallus gallus) has the putative activation motif, W[sup.18] D[sup.19...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2022-11, Vol.12 (11)
Hauptverfasser:	Dores, Robert M, McKinley, Greer, Meyers, Audrey, Ma, Shaughnessy, Ciaran A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Genomics Identification and classification Membrane proteins Phylogeny Properties
Online-Zugang:	Volltext
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