ILevilactobacillus brevis/I MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice
Alcoholic liver disease (ALD), caused by excessive alcohol consumption, leads to high mortality. We investigated the hepatoprotective effect of Levilactobacillus brevis MG5311 in C57BL/6 mice with liver injuries induced by chronic ethanol plus binge feeding. L. brevis MG5311 was administered orally...
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| Veröffentlicht in: | Microorganisms (Basel) 2022-12, Vol.10 (12) |
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| creator | Jung, Hyunna You, Sohyeon Choi, Soo-Im Kang, Chang-Ho Kim, Gun-Hee |
| description | Alcoholic liver disease (ALD), caused by excessive alcohol consumption, leads to high mortality. We investigated the hepatoprotective effect of Levilactobacillus brevis MG5311 in C57BL/6 mice with liver injuries induced by chronic ethanol plus binge feeding. L. brevis MG5311 was administered orally at a dose of 1 × 10[sup.9] CFU/mouse once daily for 32 days. L. brevis MG5311 administration significantly reduced serum ALT, AST, and triglyceride (TG) levels in ethanol-fed mice. L. brevis MG5311 also decreased malondialdehyde levels and increased glutathione peroxidase (GPx) activity in liver tissues. In addition, hepatic TG content and histopathological scores were significantly reduced. L. brevis MG5311 increased the protein expression of SIRT1, PPARα, SOD1, CAT, and GPx 1/2 in liver tissue, while inhibiting CYP2E1 and SREBP-1c. These results indicated that L. brevis MG5311 alleviated ethanol-induced liver injury by inhibiting hepatic oxidative stress and promoting lipid metabolism. Therefore, L. brevis MG5311 may be a useful probiotic candidate for ameliorating or preventing ALD. |
| doi_str_mv | 10.3390/microorganisms10122488 |
| format | Article |
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We investigated the hepatoprotective effect of Levilactobacillus brevis MG5311 in C57BL/6 mice with liver injuries induced by chronic ethanol plus binge feeding. L. brevis MG5311 was administered orally at a dose of 1 × 10[sup.9] CFU/mouse once daily for 32 days. L. brevis MG5311 administration significantly reduced serum ALT, AST, and triglyceride (TG) levels in ethanol-fed mice. L. brevis MG5311 also decreased malondialdehyde levels and increased glutathione peroxidase (GPx) activity in liver tissues. In addition, hepatic TG content and histopathological scores were significantly reduced. L. brevis MG5311 increased the protein expression of SIRT1, PPARα, SOD1, CAT, and GPx 1/2 in liver tissue, while inhibiting CYP2E1 and SREBP-1c. These results indicated that L. brevis MG5311 alleviated ethanol-induced liver injury by inhibiting hepatic oxidative stress and promoting lipid metabolism. 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We investigated the hepatoprotective effect of Levilactobacillus brevis MG5311 in C57BL/6 mice with liver injuries induced by chronic ethanol plus binge feeding. L. brevis MG5311 was administered orally at a dose of 1 × 10[sup.9] CFU/mouse once daily for 32 days. L. brevis MG5311 administration significantly reduced serum ALT, AST, and triglyceride (TG) levels in ethanol-fed mice. L. brevis MG5311 also decreased malondialdehyde levels and increased glutathione peroxidase (GPx) activity in liver tissues. In addition, hepatic TG content and histopathological scores were significantly reduced. L. brevis MG5311 increased the protein expression of SIRT1, PPARα, SOD1, CAT, and GPx 1/2 in liver tissue, while inhibiting CYP2E1 and SREBP-1c. These results indicated that L. brevis MG5311 alleviated ethanol-induced liver injury by inhibiting hepatic oxidative stress and promoting lipid metabolism. Therefore, L. brevis MG5311 may be a useful probiotic candidate for ameliorating or preventing ALD.</description><subject>Care and treatment</subject><subject>Gram-positive bacteria</subject><subject>Health aspects</subject><subject>Liver diseases</subject><subject>Oxidative stress</subject><subject>Probiotics</subject><subject>Testing</subject><issn>2076-2607</issn><issn>2076-2607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptUE1rAjEQDaWFSutfKIGeV_OxH_FoxerCige9S5Kd3UZiVpJdqdf-8qa0Bw-dOczjzXsDbxB6oWTC-YxMT0b7rvOtdCacAiWUsVSIOzRipMgTlpPi_gY_onEIRxJrRrnI6Ah9lRVcjJW675TUxtohYOUjFaYl3qwyTimeWxsJ2UPAy_5Dus4mpasHDTWuzAU8Lt1x8Fesrng3nM8eQjCuxWs4y95ovP00dQQXwLv-Z4eNw4useKumOd4YDc_ooZE2wPhvPqH9-3K_WCfVdlUu5lXS5gVNqNCguY7hGshTwoHyJqNUF5CBIhktUqoI40wIUmuVNjlRXNaUSQZEKlnzJ_T6e7aVFg7GNV3vpT6ZoA_zIk3FTMSwUTX5RxW7hvjqzkFjIn9j-AYsmnWP</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Jung, Hyunna</creator><creator>You, Sohyeon</creator><creator>Choi, Soo-Im</creator><creator>Kang, Chang-Ho</creator><creator>Kim, Gun-Hee</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20221201</creationdate><title>ILevilactobacillus brevis/I MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice</title><author>Jung, Hyunna ; You, Sohyeon ; Choi, Soo-Im ; Kang, Chang-Ho ; Kim, Gun-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g671-18cec3c488fe6403e13f511c7e5eb051741b0232880dcb4f60b3ad12a2e0abad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Care and treatment</topic><topic>Gram-positive bacteria</topic><topic>Health aspects</topic><topic>Liver diseases</topic><topic>Oxidative stress</topic><topic>Probiotics</topic><topic>Testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Hyunna</creatorcontrib><creatorcontrib>You, Sohyeon</creatorcontrib><creatorcontrib>Choi, Soo-Im</creatorcontrib><creatorcontrib>Kang, Chang-Ho</creatorcontrib><creatorcontrib>Kim, Gun-Hee</creatorcontrib><jtitle>Microorganisms (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Hyunna</au><au>You, Sohyeon</au><au>Choi, Soo-Im</au><au>Kang, Chang-Ho</au><au>Kim, Gun-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ILevilactobacillus brevis/I MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice</atitle><jtitle>Microorganisms (Basel)</jtitle><date>2022-12-01</date><risdate>2022</risdate><volume>10</volume><issue>12</issue><issn>2076-2607</issn><eissn>2076-2607</eissn><abstract>Alcoholic liver disease (ALD), caused by excessive alcohol consumption, leads to high mortality. We investigated the hepatoprotective effect of Levilactobacillus brevis MG5311 in C57BL/6 mice with liver injuries induced by chronic ethanol plus binge feeding. L. brevis MG5311 was administered orally at a dose of 1 × 10[sup.9] CFU/mouse once daily for 32 days. L. brevis MG5311 administration significantly reduced serum ALT, AST, and triglyceride (TG) levels in ethanol-fed mice. L. brevis MG5311 also decreased malondialdehyde levels and increased glutathione peroxidase (GPx) activity in liver tissues. In addition, hepatic TG content and histopathological scores were significantly reduced. L. brevis MG5311 increased the protein expression of SIRT1, PPARα, SOD1, CAT, and GPx 1/2 in liver tissue, while inhibiting CYP2E1 and SREBP-1c. These results indicated that L. brevis MG5311 alleviated ethanol-induced liver injury by inhibiting hepatic oxidative stress and promoting lipid metabolism. Therefore, L. brevis MG5311 may be a useful probiotic candidate for ameliorating or preventing ALD.</abstract><pub>MDPI AG</pub><doi>10.3390/microorganisms10122488</doi></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Care and treatment Gram-positive bacteria Health aspects Liver diseases Oxidative stress Probiotics Testing |
| title | ILevilactobacillus brevis/I MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice |
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