Folic Acid Improves Parkin-Null IDrosophila/I Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and Glutathione Redox Equilibrium

Loss-of-function parkin mutations cause oxidative stress and degeneration of dopaminergic neurons in the substantia nigra. Several consequences of parkin mutations have been described; to what degree they contribute to selective neurodegeneration remains unclear. Specific factors initiating excessiv...

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Veröffentlicht in:	Antioxidants 2022-10, Vol.11 (10)
Hauptverfasser:	Houlihan, Katherine L, Keoseyan, Petros P, Juba, Amber N, Margaryan, Tigran, Voss, Max E, Babaoghli, Alexander M, Norris, Justin M, Adrian, Greg J, Tovmasyan, Artak, Buhlman, Lori M
Format:	Artikel
Sprache:	eng
Schlagworte:	Folic acid Neural circuitry Parkinson's disease Physiological aspects
Online-Zugang:	Volltext
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