TGF-[beta] is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells

Background Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1[beta] and downregulation of IL-1 receptor antagonist, the mechanism of which remains to be fully elucidated. Previous transcriptomic data identified differential expression...

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Veröffentlicht in:	Arthritis research & therapy 2023-02, Vol.25 (1)
Hauptverfasser:	Klück, Viola, CabÄu, Georgiana, Mies, Linda, Bukkems, Femke, van Emst, Liesbeth, Bakker, René, van Caam, Arjan, Pop, Ioan V, Popp, Radu A, Rednic, Simona, Pamfil, Cristina, FarcaÅ, Marius, Marginean, DragoÅ H, Gaal, Orsolya I, Badii, Medeea O, Hotea, Ioana, Peca, Loredana, Mirea, Andreea-Manuela, Nica, Valentin, Colcear, Doina, Pop, Mariana S, Rus, Ancuta
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood cells Development and progression Genetic aspects Health aspects Hyperuricemia Inflammation Measurement Phenotype Risk factors Transforming growth factors
Online-Zugang:	Volltext
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