Association of LDL cholesterol with apolipoprotein B in essential hypertensive subjects

Essential hypertension is a major health problem in the developed countries, affecting nearly one billion people worldwide and has a strong association with cardiovascular disease (CVD). Very few studies have been undertaken to evaluate the importance of apolipoprotein B100 in predicting the risk for development of CVD in subjects of essential hypertension. Hence, we designed this study with the aim to find out the association of LDL-cholesterol with apolipoprotein B 100 in essential hypertensive subjects. The present study is a cross-sectional case-control study, conducted in the Department of Biochemistry, Gajra Raja Medical College, Gwalior. In this study, we have taken 100 subjects of essential hypertensives and 100 age and gender matched control subjects. For each subject, total cholesterol, triglycerides and HDL-C were estimated by semi auto-analyser and LDL and VLDL were calculated with the help of Friedewald equation. In addition, apolipoprotein B 100 was determined by immunoturbidimetric method. In our study, both LDL cholesterol and apolipoprotein B 100 were found to be significantly elevated in hypertensive subjects as compared to control subjects. Moreover, there was strong association between LDL-C and apolipoprotein B100 in hypertensive subjects. In conclusion, LDL-C was strongly associated with apolipoprotein B 100 in patients of essential hypertension. Hence, apolipoprotein B can be used as better marker to predict cardiovascular diseases in essential hypertension.