Adipokines profiling in North West Rajasthan patients with Metabolic syndrome for improving diagnosis and treatment modalities

Metabolic syndrome (MetS) clinically manifests through a cluster of conditions as increased BP and blood sugar, obesity, abnormal cholesterol and triglycerides culminating in diabetes, CVD and stroke. The adipose tissues keeps metabolic homeostasis well but the enlarged visceral adipocytes of obese individuals predispose insulin resistance by secreting adepokines- adiponectins and leptin. Present study evaluated circulating levels of adiponectins and leptins with anthropometric and other MetS parameters. In case vs control setting we evaluated MetS patients and controls 200 each, aged 25-65 years. As per IDF criteria anthropometry, waist circumference, BMI, WHR ratio, BP, fasting levels of glucose, total cholesterol, HDL-C, free fatty acids were measured in patients. The circulating level of adipokines like adiponectins and leptins were analysed by sandwich ELISA.