Sphingosine-1-Phosphate Signaling in Oral Carcinogenesis

Sphingosine-1-Phosphate Signaling in Oral Carcinogenesis

Oral Squamous cell carcinoma (OSCC), a subtype of head & neck cancer, is the most common cancer in Indian men. Sphingosine-1-phosphate (S1P), a potent oncogenic lipid, and its levels are regulated by eight enzymes including two sphingosine kinases (SphK1 and SphK2), five lipid phosphatases and a...

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Veröffentlicht in:Indian journal of clinical biochemistry 2022-05, Vol.33 (S1), p.S33
Hauptverfasser: Kumar, Ashok, Vishwakarma, Supriya, Joshi, Deepti, Singh, Renu
Format: Artikel
Sprache:eng
Schlagworte:
Carcinogenesis
Enzymes
Gene expression
Phosphatases
Phosphates
Sphingosine
Squamous cell carcinoma
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Zusammenfassung:Oral Squamous cell carcinoma (OSCC), a subtype of head & neck cancer, is the most common cancer in Indian men. Sphingosine-1-phosphate (S1P), a potent oncogenic lipid, and its levels are regulated by eight enzymes including two sphingosine kinases (SphK1 and SphK2), five lipid phosphatases and a S1P lyase. The role of S1P signaling in oral carcinogenesis is scantly studied.
ISSN:0970-1915