To Study The Levels of Serum Cholesterol And Hscrp Level In Children With Nephrotic Syndrome

INTRODUCTION: Nephrotic syndrome(NS)is characterized by proteinuria, edema, hypoalbuminemia and hypercholesterolemia. The latter is a risk factor for atherosclerosis suggesting a higher risk for cardiovascular disease in children suffering from NS. This change is proposed to be due to vascular endothelial dysfunction, reflecting the inflammatory response to tissue damage. One potential inflammation marker high sensitive C Reactive Protein (hsCRP) was aimed to be evaluated in these children. OBJECTIVES: Hence the study was designed to measure the levels of serum hsCRP and Cholesterol level. METHODS: It is a cross sectional study conducted in tertiary-care hospital. Forty children with first episode nephrotic syndrome attending the Pediatric Outpatient Department, Vardhaman Mahavir Medical College & Safdarjung Hospital within 14 years of age and equal no of age and sex matched healthy control children were included in the study. Serum hsCRP was measured by Enzyme linked immunosorbent assay technique and Cholesterol level by enzymatic method using cholesterol esterase and cholesterol oxidase conversion in Autoanalyser. RESULT: Serum hsCRP level was elevated in children with NS compared to healthy controls. A positive correlation between serum hsCRP and cholesterol level in cases (r=0.53, p