Correlation of Cardiac Markers With C-Reactive Protein In Patients of Acute Myocardial Infarction

INTRODUCTION: Acute myocardial infarction (AMI) is a significant cause of morbidity and mortality worldwide, which results from occlusion of coronary artery. Various cardiac markers are used for the diagnosis of AMI. Recently, a new cardiac marker i.e. glycogen phosphorylase BB (GPBB) has been invented as an early marker of AMI. AMI is associated with profound systemic inflammatory response and inflammatory marker C-reactive protein (CRP) has been found to increase after AMI. Hence, the present study attempt to investigate the correlation between inflammatory marker i.e. C-reactive protein (CRP) and cardiac markers i.e. glycogen phosphorylase BB (GPBB), Myoglobin and CKMB in AMI patients. MATERIALS AND METHODS: The present study includes 100 AMI patients and 100 normal healthy individuals as controls. In all the cases and controls, GPBB, myoglobin, CKMB and CRP were estimated. Myoglobin and GPBB were measured by ELISA where as CKMB and CRP were measured by diagnostic kits supplied by ERBA. RESULTS: The mean levels of GPBB, Myoglobin, CKMB and CRP were significantly increased in AMI cases as compared to controls. Also, there were significant positive correlations between all the studied cardiac markers and CRP in AMI cases. CONCLUSION: The positive correlation between CRP and cardiac markers in AMI indicates that there occurs inflammation in acute myocardial infarction patients. Hence, it is concluded that CRP is a risk marker of AMI and can be used for diagnostic purpose in patients of AMI. KEYWORDS: Acute myocardial infarction, Glycogen phosphorylase BB, Myoglobin, CKMB, C-reactive protein