Role of Homocysteine Metabolism and Genotype Factor V Leiden G1691a and Their Correlation With Biochemical Parameters In Patients of Cerebrovascular Stroke
INTRODUCTION: Homocysteine is a nonprotein sulphur containing amino acid formed during methionine metabolism. Elevated total plasma homocysteine levels causes moderate increase in the risk of heart disease and cerebrovascular stroke. Factor Vplaysan important role in the blood coagulation cascade, w...
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| Veröffentlicht in: | Indian journal of clinical biochemistry 2022-05, Vol.32 (S1), p.S118 |
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| creator | Kamble, Pramod Sudam Bankar, Mangesh P Kulkarni, Shreerang P Zendew, P.D |
| description | INTRODUCTION: Homocysteine is a nonprotein sulphur containing amino acid formed during methionine metabolism. Elevated total plasma homocysteine levels causes moderate increase in the risk of heart disease and cerebrovascular stroke. Factor Vplaysan important role in the blood coagulation cascade, which take part in the conversion of prothrombin to thrombin with factor Xa to form the prothrombinase complex by activated protein C. Hyper homocysteinemia may trigger single point mutation in FVL which further disturb procoagulant mechanism. AIMS AND OBJECTIVES: To study the effect of vitamin B12, Folic Acid & Homocysteine on FVLG1691A genotype among individuals suffering from cerebrovascular stroke. MATERIAL AND METHODS: The total 50 stroke patients and 50 age and gender matched healthy individuals served as controls were selected in the present study. Genotype for FVLG1691A for all above subject sand controls were determined by ARMS-PCR. RESULTS AND CONCLUSION: Median plasma total homocysteine level in stroke patients was significantly higher (p |
| format | Article |
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Elevated total plasma homocysteine levels causes moderate increase in the risk of heart disease and cerebrovascular stroke. Factor Vplaysan important role in the blood coagulation cascade, which take part in the conversion of prothrombin to thrombin with factor Xa to form the prothrombinase complex by activated protein C. Hyper homocysteinemia may trigger single point mutation in FVL which further disturb procoagulant mechanism. AIMS AND OBJECTIVES: To study the effect of vitamin B12, Folic Acid & Homocysteine on FVLG1691A genotype among individuals suffering from cerebrovascular stroke. MATERIAL AND METHODS: The total 50 stroke patients and 50 age and gender matched healthy individuals served as controls were selected in the present study. Genotype for FVLG1691A for all above subject sand controls were determined by ARMS-PCR. RESULTS AND CONCLUSION: Median plasma total homocysteine level in stroke patients was significantly higher (p<0.0001) than controls. The value of serum folic acid in stroke patients was significantly lower (p<0.05) where as the level of vitamin B12 were decreased in stroke patients, but not significant when compared with controls. We found that the effect of low dietary intake of vitamin B12&Folic Acid; genetic factors and hyperhomocysteinemia may be the plausible cause for endothelial cell injury in turn increases risk of cerebrovascular stroke and heart disease.</description><identifier>ISSN: 0970-1915</identifier><language>eng</language><publisher>Springer</publisher><subject>Folic acid ; Gene mutations ; Genetic aspects ; Heart diseases ; Homocysteine ; Physiological aspects ; Protein C ; Prothrombin ; Stroke (Disease) ; Stroke patients ; Thrombin</subject><ispartof>Indian journal of clinical biochemistry, 2022-05, Vol.32 (S1), p.S118</ispartof><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Kamble, Pramod Sudam</creatorcontrib><creatorcontrib>Bankar, Mangesh P</creatorcontrib><creatorcontrib>Kulkarni, Shreerang P</creatorcontrib><creatorcontrib>Zendew, P.D</creatorcontrib><title>Role of Homocysteine Metabolism and Genotype Factor V Leiden G1691a and Their Correlation With Biochemical Parameters In Patients of Cerebrovascular Stroke</title><title>Indian journal of clinical biochemistry</title><description>INTRODUCTION: Homocysteine is a nonprotein sulphur containing amino acid formed during methionine metabolism. Elevated total plasma homocysteine levels causes moderate increase in the risk of heart disease and cerebrovascular stroke. Factor Vplaysan important role in the blood coagulation cascade, which take part in the conversion of prothrombin to thrombin with factor Xa to form the prothrombinase complex by activated protein C. Hyper homocysteinemia may trigger single point mutation in FVL which further disturb procoagulant mechanism. AIMS AND OBJECTIVES: To study the effect of vitamin B12, Folic Acid & Homocysteine on FVLG1691A genotype among individuals suffering from cerebrovascular stroke. MATERIAL AND METHODS: The total 50 stroke patients and 50 age and gender matched healthy individuals served as controls were selected in the present study. Genotype for FVLG1691A for all above subject sand controls were determined by ARMS-PCR. RESULTS AND CONCLUSION: Median plasma total homocysteine level in stroke patients was significantly higher (p<0.0001) than controls. The value of serum folic acid in stroke patients was significantly lower (p<0.05) where as the level of vitamin B12 were decreased in stroke patients, but not significant when compared with controls. We found that the effect of low dietary intake of vitamin B12&Folic Acid; genetic factors and hyperhomocysteinemia may be the plausible cause for endothelial cell injury in turn increases risk of cerebrovascular stroke and heart disease.</description><subject>Folic acid</subject><subject>Gene mutations</subject><subject>Genetic aspects</subject><subject>Heart diseases</subject><subject>Homocysteine</subject><subject>Physiological aspects</subject><subject>Protein C</subject><subject>Prothrombin</subject><subject>Stroke (Disease)</subject><subject>Stroke patients</subject><subject>Thrombin</subject><issn>0970-1915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptj81OwzAQhHMAiVJ4h5U4cQiyZaeOjyWiP1IRqC1wrBxn0xoSG9kuap-FlyUFDlRCe1jt6psZzUnSI1KQlEqanSXnIbwSwjjhtJd8zl2D4GqYuNbpfYhoLMI9RlW6xoQWlK1gjNbF_TvCSOnoPDzDDE2FFsZ0IKn6ZpYbNB4K5z02Khpn4cXEDdwapzfYGq0aeFRetRjRB5ja7ooGbQyH8AI9lt59qKC3jfKwiN694UVyWqsm4OXv7idPo7tlMUlnD-NpMZyla0qoSHWd5SLjrEJEIjmjhHM50IIzXmJdcU1VrrGrm9G8FJRmVYV5ltGOoUIyyfrJ1Y_vWjW4MrZ20SvdmqBXQ8EE4yKXoqNu_qG6qQ71nMXadP8jwfWRoGMi7uJabUNYTRfzv-wXSJeBKA</recordid><startdate>20220524</startdate><enddate>20220524</enddate><creator>Kamble, Pramod Sudam</creator><creator>Bankar, Mangesh P</creator><creator>Kulkarni, Shreerang P</creator><creator>Zendew, P.D</creator><general>Springer</general><scope>ISR</scope></search><sort><creationdate>20220524</creationdate><title>Role of Homocysteine Metabolism and Genotype Factor V Leiden G1691a and Their Correlation With Biochemical Parameters In Patients of Cerebrovascular Stroke</title><author>Kamble, Pramod Sudam ; Bankar, Mangesh P ; Kulkarni, Shreerang P ; Zendew, P.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1017-cf587543deee0943104496c7434befd4c1a8ce404518b7115dde855196c179393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Folic acid</topic><topic>Gene mutations</topic><topic>Genetic aspects</topic><topic>Heart diseases</topic><topic>Homocysteine</topic><topic>Physiological aspects</topic><topic>Protein C</topic><topic>Prothrombin</topic><topic>Stroke (Disease)</topic><topic>Stroke patients</topic><topic>Thrombin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamble, Pramod Sudam</creatorcontrib><creatorcontrib>Bankar, Mangesh P</creatorcontrib><creatorcontrib>Kulkarni, Shreerang P</creatorcontrib><creatorcontrib>Zendew, P.D</creatorcontrib><collection>Gale In Context: Science</collection><jtitle>Indian journal of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamble, Pramod Sudam</au><au>Bankar, Mangesh P</au><au>Kulkarni, Shreerang P</au><au>Zendew, P.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Homocysteine Metabolism and Genotype Factor V Leiden G1691a and Their Correlation With Biochemical Parameters In Patients of Cerebrovascular Stroke</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><date>2022-05-24</date><risdate>2022</risdate><volume>32</volume><issue>S1</issue><spage>S118</spage><pages>S118-</pages><issn>0970-1915</issn><abstract>INTRODUCTION: Homocysteine is a nonprotein sulphur containing amino acid formed during methionine metabolism. Elevated total plasma homocysteine levels causes moderate increase in the risk of heart disease and cerebrovascular stroke. Factor Vplaysan important role in the blood coagulation cascade, which take part in the conversion of prothrombin to thrombin with factor Xa to form the prothrombinase complex by activated protein C. Hyper homocysteinemia may trigger single point mutation in FVL which further disturb procoagulant mechanism. AIMS AND OBJECTIVES: To study the effect of vitamin B12, Folic Acid & Homocysteine on FVLG1691A genotype among individuals suffering from cerebrovascular stroke. MATERIAL AND METHODS: The total 50 stroke patients and 50 age and gender matched healthy individuals served as controls were selected in the present study. Genotype for FVLG1691A for all above subject sand controls were determined by ARMS-PCR. RESULTS AND CONCLUSION: Median plasma total homocysteine level in stroke patients was significantly higher (p<0.0001) than controls. The value of serum folic acid in stroke patients was significantly lower (p<0.05) where as the level of vitamin B12 were decreased in stroke patients, but not significant when compared with controls. We found that the effect of low dietary intake of vitamin B12&Folic Acid; genetic factors and hyperhomocysteinemia may be the plausible cause for endothelial cell injury in turn increases risk of cerebrovascular stroke and heart disease.</abstract><pub>Springer</pub><tpages>1</tpages></addata></record> |
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| source | SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Folic acid Gene mutations Genetic aspects Heart diseases Homocysteine Physiological aspects Protein C Prothrombin Stroke (Disease) Stroke patients Thrombin |
| title | Role of Homocysteine Metabolism and Genotype Factor V Leiden G1691a and Their Correlation With Biochemical Parameters In Patients of Cerebrovascular Stroke |
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