Role of Homocysteine Metabolism and Genotype Factor V Leiden G1691a and Their Correlation With Biochemical Parameters In Patients of Cerebrovascular Stroke

INTRODUCTION: Homocysteine is a nonprotein sulphur containing amino acid formed during methionine metabolism. Elevated total plasma homocysteine levels causes moderate increase in the risk of heart disease and cerebrovascular stroke. Factor Vplaysan important role in the blood coagulation cascade, which take part in the conversion of prothrombin to thrombin with factor Xa to form the prothrombinase complex by activated protein C. Hyper homocysteinemia may trigger single point mutation in FVL which further disturb procoagulant mechanism. AIMS AND OBJECTIVES: To study the effect of vitamin B12, Folic Acid & Homocysteine on FVLG1691A genotype among individuals suffering from cerebrovascular stroke. MATERIAL AND METHODS: The total 50 stroke patients and 50 age and gender matched healthy individuals served as controls were selected in the present study. Genotype for FVLG1691A for all above subject sand controls were determined by ARMS-PCR. RESULTS AND CONCLUSION: Median plasma total homocysteine level in stroke patients was significantly higher (p