Clinical Status v/s Tumor Markers Levels in Esophagus Cancer Patients Following Therapy
Tumor markers are used for follow up of treatment, either for patient based or experimental conditions. There has been much optimism that sequential estimation of tumor markers concentration during the follow up of cancer patients who have undergone curative resection or therapy might detect occult...
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| Veröffentlicht in: | Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S76 |
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| creator | Bagaria, Bhawna Sood, Sadhna Sharma, Rameshwaram |
| description | Tumor markers are used for follow up of treatment, either for patient based or experimental conditions. There has been much optimism that sequential estimation of tumor markers concentration during the follow up of cancer patients who have undergone curative resection or therapy might detect occult recurrent disease early enough for further successful treatment. Tumor markers levels were studied in esophagus cancer patients before and after therapy to evaluate their prognostic significance. Results were compared with clinical response and imaging studies. Blood samples were collected from 50 patients of esophagus cancer before and six months after therapy and analysed for CEA, AFP, [beta]-HCG by Chemiluminiscence immunoassay (CLIA). CA19-9 was analysed by Enzyme linked immunosorbent assay (ELISA). Statistical differences were estimated by 't' test. Mean serum level of tumor markers (except AFP) were significantly higher in progressive disease CEA (t=2.004, P |
| format | Article |
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There has been much optimism that sequential estimation of tumor markers concentration during the follow up of cancer patients who have undergone curative resection or therapy might detect occult recurrent disease early enough for further successful treatment. Tumor markers levels were studied in esophagus cancer patients before and after therapy to evaluate their prognostic significance. Results were compared with clinical response and imaging studies. Blood samples were collected from 50 patients of esophagus cancer before and six months after therapy and analysed for CEA, AFP, [beta]-HCG by Chemiluminiscence immunoassay (CLIA). CA19-9 was analysed by Enzyme linked immunosorbent assay (ELISA). Statistical differences were estimated by 't' test. Mean serum level of tumor markers (except AFP) were significantly higher in progressive disease CEA (t=2.004, P<0.05), CA19-9 (t=2.031, P<0.05), AFP (t=0.850, P>0.05) P-HCG (t=0.043, P<0.05), and were significantly lower (exceIpt AFP with no change) in improved condition CEA (t=3.069, p<0.01) CA19-9 (t=2.958, P<0.01) AFP (t=1.761, P>0.05) and [beta]-HCG (t=3.264, P<0.01) when compared with levels before therapy. There was no change seen in tumor markers level in patients who were in stable condition. The results correlated well with imaging studies and clinical response of patients. By using the information that these markers can provide, patient-specific treatment protocols can be developed, implemented, and monitored for improved patient outcomes.]]></description><identifier>ISSN: 0970-1915</identifier><language>eng</language><publisher>Springer</publisher><subject>Cancer ; Cancer patients ; Care and treatment ; CEA (Oncology) ; Comparative analysis ; Esophageal cancer ; Health aspects ; Medical research ; Medicine, Experimental ; Tumors</subject><ispartof>Indian journal of clinical biochemistry, 2014-12, Vol.29 (S1), p.S76</ispartof><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Bagaria, Bhawna</creatorcontrib><creatorcontrib>Sood, Sadhna</creatorcontrib><creatorcontrib>Sharma, Rameshwaram</creatorcontrib><title>Clinical Status v/s Tumor Markers Levels in Esophagus Cancer Patients Following Therapy</title><title>Indian journal of clinical biochemistry</title><description><![CDATA[Tumor markers are used for follow up of treatment, either for patient based or experimental conditions. There has been much optimism that sequential estimation of tumor markers concentration during the follow up of cancer patients who have undergone curative resection or therapy might detect occult recurrent disease early enough for further successful treatment. Tumor markers levels were studied in esophagus cancer patients before and after therapy to evaluate their prognostic significance. Results were compared with clinical response and imaging studies. Blood samples were collected from 50 patients of esophagus cancer before and six months after therapy and analysed for CEA, AFP, [beta]-HCG by Chemiluminiscence immunoassay (CLIA). CA19-9 was analysed by Enzyme linked immunosorbent assay (ELISA). Statistical differences were estimated by 't' test. Mean serum level of tumor markers (except AFP) were significantly higher in progressive disease CEA (t=2.004, P<0.05), CA19-9 (t=2.031, P<0.05), AFP (t=0.850, P>0.05) P-HCG (t=0.043, P<0.05), and were significantly lower (exceIpt AFP with no change) in improved condition CEA (t=3.069, p<0.01) CA19-9 (t=2.958, P<0.01) AFP (t=1.761, P>0.05) and [beta]-HCG (t=3.264, P<0.01) when compared with levels before therapy. There was no change seen in tumor markers level in patients who were in stable condition. The results correlated well with imaging studies and clinical response of patients. By using the information that these markers can provide, patient-specific treatment protocols can be developed, implemented, and monitored for improved patient outcomes.]]></description><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>CEA (Oncology)</subject><subject>Comparative analysis</subject><subject>Esophageal cancer</subject><subject>Health aspects</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Tumors</subject><issn>0970-1915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjEFLwzAYhntQcE7_Q8BzNWnSL81xlE2FioIFj-NLmnTRLB1NN_HfW9CDB3kPD7w873uWLaiSNGeKlRfZZUrvlHJBBVtkb3Xw0RsM5HXC6ZjI6S6R9rgfRvKE44cdE2nsyYZEfCTrNBx22M9WjdHYkbzg5G2cEtkMIQyfPvak3dkRD19X2bnDkOz1L5dZu1m39UPePN8_1qsm70FCDqoQrOBKa8UAoegMaEBWMlSSS6dBVZ0zEplxiqlKM2BaCYSKd5RDKfgyu_m57THYrY9umEY0e5_MdiU5iKIqKczW7T_WnM7uvRmidX7u_wy-AegzWuU</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Bagaria, Bhawna</creator><creator>Sood, Sadhna</creator><creator>Sharma, Rameshwaram</creator><general>Springer</general><scope/></search><sort><creationdate>20141201</creationdate><title>Clinical Status v/s Tumor Markers Levels in Esophagus Cancer Patients Following Therapy</title><author>Bagaria, Bhawna ; Sood, Sadhna ; Sharma, Rameshwaram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g676-69241239bb916a62dc6b6a151a9737fb698dfc7a1cf9198b161b94a683d036543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>CEA (Oncology)</topic><topic>Comparative analysis</topic><topic>Esophageal cancer</topic><topic>Health aspects</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagaria, Bhawna</creatorcontrib><creatorcontrib>Sood, Sadhna</creatorcontrib><creatorcontrib>Sharma, Rameshwaram</creatorcontrib><jtitle>Indian journal of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagaria, Bhawna</au><au>Sood, Sadhna</au><au>Sharma, Rameshwaram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Status v/s Tumor Markers Levels in Esophagus Cancer Patients Following Therapy</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><date>2014-12-01</date><risdate>2014</risdate><volume>29</volume><issue>S1</issue><spage>S76</spage><pages>S76-</pages><issn>0970-1915</issn><abstract><![CDATA[Tumor markers are used for follow up of treatment, either for patient based or experimental conditions. There has been much optimism that sequential estimation of tumor markers concentration during the follow up of cancer patients who have undergone curative resection or therapy might detect occult recurrent disease early enough for further successful treatment. Tumor markers levels were studied in esophagus cancer patients before and after therapy to evaluate their prognostic significance. Results were compared with clinical response and imaging studies. Blood samples were collected from 50 patients of esophagus cancer before and six months after therapy and analysed for CEA, AFP, [beta]-HCG by Chemiluminiscence immunoassay (CLIA). CA19-9 was analysed by Enzyme linked immunosorbent assay (ELISA). Statistical differences were estimated by 't' test. Mean serum level of tumor markers (except AFP) were significantly higher in progressive disease CEA (t=2.004, P<0.05), CA19-9 (t=2.031, P<0.05), AFP (t=0.850, P>0.05) P-HCG (t=0.043, P<0.05), and were significantly lower (exceIpt AFP with no change) in improved condition CEA (t=3.069, p<0.01) CA19-9 (t=2.958, P<0.01) AFP (t=1.761, P>0.05) and [beta]-HCG (t=3.264, P<0.01) when compared with levels before therapy. There was no change seen in tumor markers level in patients who were in stable condition. The results correlated well with imaging studies and clinical response of patients. By using the information that these markers can provide, patient-specific treatment protocols can be developed, implemented, and monitored for improved patient outcomes.]]></abstract><pub>Springer</pub></addata></record> |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Cancer Cancer patients Care and treatment CEA (Oncology) Comparative analysis Esophageal cancer Health aspects Medical research Medicine, Experimental Tumors |
| title | Clinical Status v/s Tumor Markers Levels in Esophagus Cancer Patients Following Therapy |
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