The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C
Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departm...
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| creator | Rowan, Sarah E Haukoos, Jason Kamis, Kevin F Hopkins, Emily Gravitz, Stephanie Lyle, Carolynn Al-Tayyib, Alia A Gardner, Edward M Galbraith, James W Hsieh, Yu-Hsiang Lyons, Michael S Rothman, Richard E White, Douglas A. E Morgan, Jake R Linas, Benjamin P Sabel, Allison L Wyles, David L Adler, Amy Alishahi, Musheng Avornu, Gideon D Becerra, Alexis Becerra-Ashby, Erika Bellamy, Meghan Bot, Samantha Boyle, Alexander J Bracey, Annetta M Breyer, Michael Camacho, Claudia Cupelo, Alicia Dashler, Gaby Doyle, Pamela Eicher, Amy Gardner, Heather de Gruiter, Carrie Anne Henry, Sophia Higgins, David Hill, Trevor Houk, Rachel Johnson, Nyah Kile, Alex Liebl, Janet Maliszewski, Barbara Maliszewski, Kendall McGoey, Robert McKenzie, Catherine Minturn, Matthew S Myer, Deanna Neumann, Kendra Ossian, Cole Peacock, Rebekah K Perez, Danielle Pramanick, Tannishtha Ricketts, Erin P Riggan, Benji Riser, Sherry Roosevelt, Genie Saheed, Mustapha Schumacher, Sarah Shy, Bradley Simpson, Scott Toerper, Matthew F Trest, Gil Unsworth, Madison Waltrous, Laura Watson, Brooke |
| description | Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial. Methods The DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O'Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. Discussion When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV. Trial registration ClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: Keywords: Hepatitis C, HCV, Linkage-to-care, Navigation, Clinical trial, Randomized trial, Emergency department, Comparative effectiveness, Methods, Implementation |
| doi_str_mv | 10.1186/s13063-022-07018-w |
| format | Article |
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E ; Morgan, Jake R ; Linas, Benjamin P ; Sabel, Allison L ; Wyles, David L ; Adler, Amy ; Alishahi, Musheng ; Avornu, Gideon D ; Becerra, Alexis ; Becerra-Ashby, Erika ; Bellamy, Meghan ; Bot, Samantha ; Boyle, Alexander J ; Bracey, Annetta M ; Breyer, Michael ; Camacho, Claudia ; Cupelo, Alicia ; Dashler, Gaby ; Doyle, Pamela ; Eicher, Amy ; Gardner, Heather ; de Gruiter, Carrie Anne ; Henry, Sophia ; Higgins, David ; Hill, Trevor ; Houk, Rachel ; Johnson, Nyah ; Kile, Alex ; Liebl, Janet ; Maliszewski, Barbara ; Maliszewski, Kendall ; McGoey, Robert ; McKenzie, Catherine ; Minturn, Matthew S ; Myer, Deanna ; Neumann, Kendra ; Ossian, Cole ; Peacock, Rebekah K ; Perez, Danielle ; Pramanick, Tannishtha ; Ricketts, Erin P ; Riggan, Benji ; Riser, Sherry ; Roosevelt, Genie ; Saheed, Mustapha ; Schumacher, Sarah ; Shy, Bradley ; Simpson, Scott ; Toerper, Matthew F ; Trest, Gil ; Unsworth, Madison ; Waltrous, Laura ; Watson, Brooke</creator><creatorcontrib>Rowan, Sarah E ; Haukoos, Jason ; Kamis, Kevin F ; Hopkins, Emily ; Gravitz, Stephanie ; Lyle, Carolynn ; Al-Tayyib, Alia A ; Gardner, Edward M ; Galbraith, James W ; Hsieh, Yu-Hsiang ; Lyons, Michael S ; Rothman, Richard E ; White, Douglas A. E ; Morgan, Jake R ; Linas, Benjamin P ; Sabel, Allison L ; Wyles, David L ; Adler, Amy ; Alishahi, Musheng ; Avornu, Gideon D ; Becerra, Alexis ; Becerra-Ashby, Erika ; Bellamy, Meghan ; Bot, Samantha ; Boyle, Alexander J ; Bracey, Annetta M ; Breyer, Michael ; Camacho, Claudia ; Cupelo, Alicia ; Dashler, Gaby ; Doyle, Pamela ; Eicher, Amy ; Gardner, Heather ; de Gruiter, Carrie Anne ; Henry, Sophia ; Higgins, David ; Hill, Trevor ; Houk, Rachel ; Johnson, Nyah ; Kile, Alex ; Liebl, Janet ; Maliszewski, Barbara ; Maliszewski, Kendall ; McGoey, Robert ; McKenzie, Catherine ; Minturn, Matthew S ; Myer, Deanna ; Neumann, Kendra ; Ossian, Cole ; Peacock, Rebekah K ; Perez, Danielle ; Pramanick, Tannishtha ; Ricketts, Erin P ; Riggan, Benji ; Riser, Sherry ; Roosevelt, Genie ; Saheed, Mustapha ; Schumacher, Sarah ; Shy, Bradley ; Simpson, Scott ; Toerper, Matthew F ; Trest, Gil ; Unsworth, Madison ; Waltrous, Laura ; Watson, Brooke</creatorcontrib><description>Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial. Methods The DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O'Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. Discussion When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV. Trial registration ClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: Keywords: Hepatitis C, HCV, Linkage-to-care, Navigation, Clinical trial, Randomized trial, Emergency department, Comparative effectiveness, Methods, Implementation</description><identifier>ISSN: 1745-6215</identifier><identifier>EISSN: 1745-6215</identifier><identifier>DOI: 10.1186/s13063-022-07018-w</identifier><language>eng</language><publisher>BioMed Central Ltd</publisher><subject>Analysis ; Care and treatment ; Demographic aspects ; Development and progression ; Economic aspects ; Emergency service ; Health care disparities ; Hepatitis C ; Hospitals ; Medical record linkage ; Social aspects</subject><ispartof>Trials, 2023-01, Vol.24 (1)</ispartof><rights>COPYRIGHT 2023 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids></links><search><creatorcontrib>Rowan, Sarah E</creatorcontrib><creatorcontrib>Haukoos, Jason</creatorcontrib><creatorcontrib>Kamis, Kevin F</creatorcontrib><creatorcontrib>Hopkins, Emily</creatorcontrib><creatorcontrib>Gravitz, Stephanie</creatorcontrib><creatorcontrib>Lyle, Carolynn</creatorcontrib><creatorcontrib>Al-Tayyib, Alia A</creatorcontrib><creatorcontrib>Gardner, Edward M</creatorcontrib><creatorcontrib>Galbraith, James W</creatorcontrib><creatorcontrib>Hsieh, Yu-Hsiang</creatorcontrib><creatorcontrib>Lyons, Michael S</creatorcontrib><creatorcontrib>Rothman, Richard E</creatorcontrib><creatorcontrib>White, Douglas A. E</creatorcontrib><creatorcontrib>Morgan, Jake R</creatorcontrib><creatorcontrib>Linas, Benjamin P</creatorcontrib><creatorcontrib>Sabel, Allison L</creatorcontrib><creatorcontrib>Wyles, David L</creatorcontrib><creatorcontrib>Adler, Amy</creatorcontrib><creatorcontrib>Alishahi, Musheng</creatorcontrib><creatorcontrib>Avornu, Gideon D</creatorcontrib><creatorcontrib>Becerra, Alexis</creatorcontrib><creatorcontrib>Becerra-Ashby, Erika</creatorcontrib><creatorcontrib>Bellamy, Meghan</creatorcontrib><creatorcontrib>Bot, Samantha</creatorcontrib><creatorcontrib>Boyle, Alexander J</creatorcontrib><creatorcontrib>Bracey, Annetta M</creatorcontrib><creatorcontrib>Breyer, Michael</creatorcontrib><creatorcontrib>Camacho, Claudia</creatorcontrib><creatorcontrib>Cupelo, Alicia</creatorcontrib><creatorcontrib>Dashler, Gaby</creatorcontrib><creatorcontrib>Doyle, Pamela</creatorcontrib><creatorcontrib>Eicher, Amy</creatorcontrib><creatorcontrib>Gardner, Heather</creatorcontrib><creatorcontrib>de Gruiter, Carrie Anne</creatorcontrib><creatorcontrib>Henry, Sophia</creatorcontrib><creatorcontrib>Higgins, David</creatorcontrib><creatorcontrib>Hill, Trevor</creatorcontrib><creatorcontrib>Houk, Rachel</creatorcontrib><creatorcontrib>Johnson, Nyah</creatorcontrib><creatorcontrib>Kile, Alex</creatorcontrib><creatorcontrib>Liebl, Janet</creatorcontrib><creatorcontrib>Maliszewski, Barbara</creatorcontrib><creatorcontrib>Maliszewski, Kendall</creatorcontrib><creatorcontrib>McGoey, Robert</creatorcontrib><creatorcontrib>McKenzie, Catherine</creatorcontrib><creatorcontrib>Minturn, Matthew S</creatorcontrib><creatorcontrib>Myer, Deanna</creatorcontrib><creatorcontrib>Neumann, Kendra</creatorcontrib><creatorcontrib>Ossian, Cole</creatorcontrib><creatorcontrib>Peacock, Rebekah K</creatorcontrib><creatorcontrib>Perez, Danielle</creatorcontrib><creatorcontrib>Pramanick, Tannishtha</creatorcontrib><creatorcontrib>Ricketts, Erin P</creatorcontrib><creatorcontrib>Riggan, Benji</creatorcontrib><creatorcontrib>Riser, Sherry</creatorcontrib><creatorcontrib>Roosevelt, Genie</creatorcontrib><creatorcontrib>Saheed, Mustapha</creatorcontrib><creatorcontrib>Schumacher, Sarah</creatorcontrib><creatorcontrib>Shy, Bradley</creatorcontrib><creatorcontrib>Simpson, Scott</creatorcontrib><creatorcontrib>Toerper, Matthew F</creatorcontrib><creatorcontrib>Trest, Gil</creatorcontrib><creatorcontrib>Unsworth, Madison</creatorcontrib><creatorcontrib>Waltrous, Laura</creatorcontrib><creatorcontrib>Watson, Brooke</creatorcontrib><title>The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C</title><title>Trials</title><description>Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial. Methods The DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O'Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. Discussion When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV. Trial registration ClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: Keywords: Hepatitis C, HCV, Linkage-to-care, Navigation, Clinical trial, Randomized trial, Emergency department, Comparative effectiveness, Methods, Implementation</description><subject>Analysis</subject><subject>Care and treatment</subject><subject>Demographic aspects</subject><subject>Development and progression</subject><subject>Economic aspects</subject><subject>Emergency service</subject><subject>Health care disparities</subject><subject>Hepatitis C</subject><subject>Hospitals</subject><subject>Medical record linkage</subject><subject>Social aspects</subject><issn>1745-6215</issn><issn>1745-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptT01v1DAQjRBIlMIf4GSJs4sdJ3HCrUq3BWmlXnKvJvY4HUjsynZbwV_ngneLSg_Iljzz9L5cVR-lOJOy7z4nqUSnuKhrLrSQPX98VZ1I3bS8q2X7-sX8tnqX0nchGjWo5qT6Pd0iu8CMcSNPfmE759BkekA2YcoHhDzbbRgX9OZnod5BzBv6nBh4y0aIyMYQoiUPmYJn5U4R4chh1_fZhA0T25P_AQvyHPhRMkWC9QuLRw2seDSzmGgpDq5sDJ8z7XMmnyGhLSpvw0a_ymjWUtvAyvLB8CBd_yWZQ1LKJQQXKiVciOy2mGXKlNj4vnrjYE344e97Wk2Xu2n8yvfXV9_G8z1fOq15Z9t-7o2s0fYgodN9B87OUtphwHkQau5UwaRDO9SgXIsNzG0z9L0EoWdUp9WnJ9ul_POGvAulkdkomZtzrZqh0a3WhXX2H1Y5FjcywaOjgr8Q_AE8OqDo</recordid><startdate>20230127</startdate><enddate>20230127</enddate><creator>Rowan, Sarah E</creator><creator>Haukoos, Jason</creator><creator>Kamis, Kevin F</creator><creator>Hopkins, Emily</creator><creator>Gravitz, Stephanie</creator><creator>Lyle, Carolynn</creator><creator>Al-Tayyib, Alia A</creator><creator>Gardner, Edward M</creator><creator>Galbraith, James W</creator><creator>Hsieh, Yu-Hsiang</creator><creator>Lyons, Michael S</creator><creator>Rothman, Richard E</creator><creator>White, Douglas A. 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E ; Morgan, Jake R ; Linas, Benjamin P ; Sabel, Allison L ; Wyles, David L ; Adler, Amy ; Alishahi, Musheng ; Avornu, Gideon D ; Becerra, Alexis ; Becerra-Ashby, Erika ; Bellamy, Meghan ; Bot, Samantha ; Boyle, Alexander J ; Bracey, Annetta M ; Breyer, Michael ; Camacho, Claudia ; Cupelo, Alicia ; Dashler, Gaby ; Doyle, Pamela ; Eicher, Amy ; Gardner, Heather ; de Gruiter, Carrie Anne ; Henry, Sophia ; Higgins, David ; Hill, Trevor ; Houk, Rachel ; Johnson, Nyah ; Kile, Alex ; Liebl, Janet ; Maliszewski, Barbara ; Maliszewski, Kendall ; McGoey, Robert ; McKenzie, Catherine ; Minturn, Matthew S ; Myer, Deanna ; Neumann, Kendra ; Ossian, Cole ; Peacock, Rebekah K ; Perez, Danielle ; Pramanick, Tannishtha ; Ricketts, Erin P ; Riggan, Benji ; Riser, Sherry ; Roosevelt, Genie ; Saheed, Mustapha ; Schumacher, Sarah ; Shy, Bradley ; Simpson, Scott ; Toerper, Matthew F ; Trest, Gil ; Unsworth, Madison ; Waltrous, Laura ; Watson, Brooke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g677-6d58b8c12ed8a1a6786afdb11d99eb903b637861fed92a3f5e4ab549881a07be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Care and treatment</topic><topic>Demographic aspects</topic><topic>Development and progression</topic><topic>Economic aspects</topic><topic>Emergency service</topic><topic>Health care disparities</topic><topic>Hepatitis C</topic><topic>Hospitals</topic><topic>Medical record linkage</topic><topic>Social aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowan, Sarah E</creatorcontrib><creatorcontrib>Haukoos, Jason</creatorcontrib><creatorcontrib>Kamis, Kevin F</creatorcontrib><creatorcontrib>Hopkins, Emily</creatorcontrib><creatorcontrib>Gravitz, Stephanie</creatorcontrib><creatorcontrib>Lyle, Carolynn</creatorcontrib><creatorcontrib>Al-Tayyib, Alia A</creatorcontrib><creatorcontrib>Gardner, Edward M</creatorcontrib><creatorcontrib>Galbraith, James W</creatorcontrib><creatorcontrib>Hsieh, Yu-Hsiang</creatorcontrib><creatorcontrib>Lyons, Michael S</creatorcontrib><creatorcontrib>Rothman, Richard E</creatorcontrib><creatorcontrib>White, Douglas A. E</creatorcontrib><creatorcontrib>Morgan, Jake R</creatorcontrib><creatorcontrib>Linas, Benjamin P</creatorcontrib><creatorcontrib>Sabel, Allison L</creatorcontrib><creatorcontrib>Wyles, David L</creatorcontrib><creatorcontrib>Adler, Amy</creatorcontrib><creatorcontrib>Alishahi, Musheng</creatorcontrib><creatorcontrib>Avornu, Gideon D</creatorcontrib><creatorcontrib>Becerra, Alexis</creatorcontrib><creatorcontrib>Becerra-Ashby, Erika</creatorcontrib><creatorcontrib>Bellamy, Meghan</creatorcontrib><creatorcontrib>Bot, Samantha</creatorcontrib><creatorcontrib>Boyle, Alexander J</creatorcontrib><creatorcontrib>Bracey, Annetta M</creatorcontrib><creatorcontrib>Breyer, Michael</creatorcontrib><creatorcontrib>Camacho, Claudia</creatorcontrib><creatorcontrib>Cupelo, Alicia</creatorcontrib><creatorcontrib>Dashler, Gaby</creatorcontrib><creatorcontrib>Doyle, Pamela</creatorcontrib><creatorcontrib>Eicher, Amy</creatorcontrib><creatorcontrib>Gardner, Heather</creatorcontrib><creatorcontrib>de Gruiter, Carrie Anne</creatorcontrib><creatorcontrib>Henry, Sophia</creatorcontrib><creatorcontrib>Higgins, David</creatorcontrib><creatorcontrib>Hill, Trevor</creatorcontrib><creatorcontrib>Houk, Rachel</creatorcontrib><creatorcontrib>Johnson, Nyah</creatorcontrib><creatorcontrib>Kile, Alex</creatorcontrib><creatorcontrib>Liebl, Janet</creatorcontrib><creatorcontrib>Maliszewski, Barbara</creatorcontrib><creatorcontrib>Maliszewski, Kendall</creatorcontrib><creatorcontrib>McGoey, Robert</creatorcontrib><creatorcontrib>McKenzie, Catherine</creatorcontrib><creatorcontrib>Minturn, Matthew S</creatorcontrib><creatorcontrib>Myer, Deanna</creatorcontrib><creatorcontrib>Neumann, Kendra</creatorcontrib><creatorcontrib>Ossian, Cole</creatorcontrib><creatorcontrib>Peacock, Rebekah K</creatorcontrib><creatorcontrib>Perez, Danielle</creatorcontrib><creatorcontrib>Pramanick, Tannishtha</creatorcontrib><creatorcontrib>Ricketts, Erin P</creatorcontrib><creatorcontrib>Riggan, Benji</creatorcontrib><creatorcontrib>Riser, Sherry</creatorcontrib><creatorcontrib>Roosevelt, Genie</creatorcontrib><creatorcontrib>Saheed, Mustapha</creatorcontrib><creatorcontrib>Schumacher, Sarah</creatorcontrib><creatorcontrib>Shy, Bradley</creatorcontrib><creatorcontrib>Simpson, Scott</creatorcontrib><creatorcontrib>Toerper, Matthew F</creatorcontrib><creatorcontrib>Trest, Gil</creatorcontrib><creatorcontrib>Unsworth, Madison</creatorcontrib><creatorcontrib>Waltrous, Laura</creatorcontrib><creatorcontrib>Watson, Brooke</creatorcontrib><jtitle>Trials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowan, Sarah E</au><au>Haukoos, Jason</au><au>Kamis, Kevin F</au><au>Hopkins, Emily</au><au>Gravitz, Stephanie</au><au>Lyle, Carolynn</au><au>Al-Tayyib, Alia A</au><au>Gardner, Edward M</au><au>Galbraith, James W</au><au>Hsieh, Yu-Hsiang</au><au>Lyons, Michael S</au><au>Rothman, Richard E</au><au>White, Douglas A. E</au><au>Morgan, Jake R</au><au>Linas, Benjamin P</au><au>Sabel, Allison L</au><au>Wyles, David L</au><au>Adler, Amy</au><au>Alishahi, Musheng</au><au>Avornu, Gideon D</au><au>Becerra, Alexis</au><au>Becerra-Ashby, Erika</au><au>Bellamy, Meghan</au><au>Bot, Samantha</au><au>Boyle, Alexander J</au><au>Bracey, Annetta M</au><au>Breyer, Michael</au><au>Camacho, Claudia</au><au>Cupelo, Alicia</au><au>Dashler, Gaby</au><au>Doyle, Pamela</au><au>Eicher, Amy</au><au>Gardner, Heather</au><au>de Gruiter, Carrie Anne</au><au>Henry, Sophia</au><au>Higgins, David</au><au>Hill, Trevor</au><au>Houk, Rachel</au><au>Johnson, Nyah</au><au>Kile, Alex</au><au>Liebl, Janet</au><au>Maliszewski, Barbara</au><au>Maliszewski, Kendall</au><au>McGoey, Robert</au><au>McKenzie, Catherine</au><au>Minturn, Matthew S</au><au>Myer, Deanna</au><au>Neumann, Kendra</au><au>Ossian, Cole</au><au>Peacock, Rebekah K</au><au>Perez, Danielle</au><au>Pramanick, Tannishtha</au><au>Ricketts, Erin P</au><au>Riggan, Benji</au><au>Riser, Sherry</au><au>Roosevelt, Genie</au><au>Saheed, Mustapha</au><au>Schumacher, Sarah</au><au>Shy, Bradley</au><au>Simpson, Scott</au><au>Toerper, Matthew F</au><au>Trest, Gil</au><au>Unsworth, Madison</au><au>Waltrous, Laura</au><au>Watson, Brooke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C</atitle><jtitle>Trials</jtitle><date>2023-01-27</date><risdate>2023</risdate><volume>24</volume><issue>1</issue><issn>1745-6215</issn><eissn>1745-6215</eissn><abstract>Background Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial. Methods The DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O'Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. Discussion When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV. Trial registration ClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: Keywords: Hepatitis C, HCV, Linkage-to-care, Navigation, Clinical trial, Randomized trial, Emergency department, Comparative effectiveness, Methods, Implementation</abstract><pub>BioMed Central Ltd</pub><doi>10.1186/s13063-022-07018-w</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1745-6215 |
| ispartof | Trials, 2023-01, Vol.24 (1) |
| issn | 1745-6215 1745-6215 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A734947577 |
| source | DOAJ Directory of Open Access Journals; SpringerLink Journals; PubMed Central Open Access; Springer Nature OA Free Journals; PubMed Central |
| subjects | Analysis Care and treatment Demographic aspects Development and progression Economic aspects Emergency service Health care disparities Hepatitis C Hospitals Medical record linkage Social aspects |
| title | The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C |
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