Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-[beta] inhibition

Background Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor characterized by an intensive desmoplastic reaction due to the exaggerated presence of the extracellular (ECM) matrix components. Liver fibroblasts close to the tumor, activated by transforming growth factor (TGF)-[beta]1...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2022-11, Vol.41 (1)
Hauptverfasser:	Mancarella, Serena, Gigante, Isabella, Serino, Grazia, Pizzuto, Elena, Dituri, Francesco, Valentini, Maria F, Wang, Jingxiao, Chen, Xin, Armentano, Raffaele, Calvisi, Diego F, Giannelli, Gianluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biotechnology industry Collagen Development and progression Ecosystems Fibrosis Gene expression Liver Liver diseases Muscle proteins Scientific equipment and supplies industry Transforming growth factors
Online-Zugang:	Volltext
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