Cardiovascular risk assessment after anti-TNF treatment in patients with rheumatoid arthritis and ankylosing spondylitis with Strain Echocardiography/Romatoid artrit ve ankilozan spondilit hastalarinda anti-TNF tedavisi sonrasi Strain Echo ile kardiyovaskuler risk degerlendirmesi

Objective: The aim of this study was to investigate the effects of antitumor necrosis factor (anti-TNF) agents on myocardial function and cardiovascular risk factors in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients receiving anti-TNF agents for inflammatory arthritis for six mon...

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Veröffentlicht in:Journal of Turkish Society for Rheumatology 2022-12, Vol.14 (3), p.117
Hauptverfasser: Yonak, Asli Karadeniz, Dayan, Akin, Ozen, Gulsen, Sunbul, Murat, Atagunduz, Mehmet Pamir, Inane, Nevsun
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container_issue 3
container_start_page 117
container_title Journal of Turkish Society for Rheumatology
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creator Yonak, Asli Karadeniz
Dayan, Akin
Ozen, Gulsen
Sunbul, Murat
Atagunduz, Mehmet Pamir
Inane, Nevsun
description Objective: The aim of this study was to investigate the effects of antitumor necrosis factor (anti-TNF) agents on myocardial function and cardiovascular risk factors in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients receiving anti-TNF agents for inflammatory arthritis for six months by using standard and speckle tracking echocardiography. Methods: The study was conducted on a group of 30 patients composed of 12 with RA and 18 with AS. Demographic, standard and speckle tracking echocardiographic data, disease activities, laboratory results related to our research were prospectively assessed. Results: In the study, there was a statistically significant decrease in disease activity score, Bath Ankylosing Spondylitis Disease Activity index, Health Assessment Questionnaire, and Bath Ankylosing Spondylitis Functional Index scores and erythrocyte sedimentation rate, C-reactive protein values of patients with RA and AS in the sixth month of anti-TNF treatment. There was a decrease in left ventricular global longitudinal strain values assessed with speckle tracking echocardiography in the sixth month compared to the baseline and this difference was statistically significant. Conclusion: Myocardial strain imaging might be useful in assessing the early development of cardiac failure in patients with high cardiovascular risk, such as patients with RA and AS. Keywords: Tumor necrosis factor antagonist, cardiovascular risk, rheumatoid arthritis, ankylosing spondylitis Amac: Calismanin amaci, romatoid artrit (RA) ve ankilozan spondilit (AS) hastalarinda, alti ay sureyle anti-tumor nekroz faktoru (anti-TNF) ku llanim in in miyokard fonksiyonu ve kardiyovaskuler risk faktorleri uzerindeki etkilerini standart ve speckle tracking ekokardiyografi kullanarak arastirmaktir. Yontem: Calismaya 12 RA ve 18 AS olmak uzere toplam 30 hasta dahil edildi. Arastirmamizla ilgili demografik, standart ve speckle tracking ekokardiyografik veriler, hastalik aktiviteleri, laboratuvar sonuclari prospektif olarak degerlendirildi. Bulgular: Calismada anti-TNF tedavisinin altinci ayinda RA ve AS'li hastalarin hastalik aktivite skoru, Bath Ankilozan Spondilit Hastalik Aktivite indeksi, Saglik Degerlendirme Anketi ve Bath Ankilozan Spondilit Fonksiyonel indeksi skorlarinda ve eritrosit sedimentasyon hizinda, C-reaktif protein degerlerinde istatistiksel olarak anlamli dusus saptandi. Speckle tracking ekokardiyografi ile degerlendirilen sol ventrikul global longitudinal strain deg
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Methods: The study was conducted on a group of 30 patients composed of 12 with RA and 18 with AS. Demographic, standard and speckle tracking echocardiographic data, disease activities, laboratory results related to our research were prospectively assessed. Results: In the study, there was a statistically significant decrease in disease activity score, Bath Ankylosing Spondylitis Disease Activity index, Health Assessment Questionnaire, and Bath Ankylosing Spondylitis Functional Index scores and erythrocyte sedimentation rate, C-reactive protein values of patients with RA and AS in the sixth month of anti-TNF treatment. There was a decrease in left ventricular global longitudinal strain values assessed with speckle tracking echocardiography in the sixth month compared to the baseline and this difference was statistically significant. Conclusion: Myocardial strain imaging might be useful in assessing the early development of cardiac failure in patients with high cardiovascular risk, such as patients with RA and AS. Keywords: Tumor necrosis factor antagonist, cardiovascular risk, rheumatoid arthritis, ankylosing spondylitis Amac: Calismanin amaci, romatoid artrit (RA) ve ankilozan spondilit (AS) hastalarinda, alti ay sureyle anti-tumor nekroz faktoru (anti-TNF) ku llanim in in miyokard fonksiyonu ve kardiyovaskuler risk faktorleri uzerindeki etkilerini standart ve speckle tracking ekokardiyografi kullanarak arastirmaktir. Yontem: Calismaya 12 RA ve 18 AS olmak uzere toplam 30 hasta dahil edildi. Arastirmamizla ilgili demografik, standart ve speckle tracking ekokardiyografik veriler, hastalik aktiviteleri, laboratuvar sonuclari prospektif olarak degerlendirildi. Bulgular: Calismada anti-TNF tedavisinin altinci ayinda RA ve AS'li hastalarin hastalik aktivite skoru, Bath Ankilozan Spondilit Hastalik Aktivite indeksi, Saglik Degerlendirme Anketi ve Bath Ankilozan Spondilit Fonksiyonel indeksi skorlarinda ve eritrosit sedimentasyon hizinda, C-reaktif protein degerlerinde istatistiksel olarak anlamli dusus saptandi. Speckle tracking ekokardiyografi ile degerlendirilen sol ventrikul global longitudinal strain degerlerinde baslangica kiyasla altinci ayda istatistiksel olarak anlamli azalma oldugu saptandi. Sonuc: Miyokardiyal strain goruntulemesi RA ve AS'li hastalar gibi yuksek kardiyovaskuler riski olan hastalarda kalp yetmezliginin erken gelisimini degerlendirmede yararli olabilir. Anahtar Kelimeler: Tumor nekroz faktor antagonist, kardiyovaskuler risk, romatoid artrit, ankilozan spondilit</description><identifier>ISSN: 2651-2653</identifier><identifier>DOI: 10.4274/raed.galenos.2022.25744</identifier><language>eng</language><publisher>Galenos Yayinevi Tic. Ltd</publisher><subject>Ankylosing spondylitis ; Antiarthritic agents ; Blood ; Care and treatment ; Heart failure ; Medical examination ; Rheumatoid factor ; Risk assessment ; Tumor necrosis factor</subject><ispartof>Journal of Turkish Society for Rheumatology, 2022-12, Vol.14 (3), p.117</ispartof><rights>COPYRIGHT 2022 Galenos Yayinevi Tic. Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids></links><search><creatorcontrib>Yonak, Asli Karadeniz</creatorcontrib><creatorcontrib>Dayan, Akin</creatorcontrib><creatorcontrib>Ozen, Gulsen</creatorcontrib><creatorcontrib>Sunbul, Murat</creatorcontrib><creatorcontrib>Atagunduz, Mehmet Pamir</creatorcontrib><creatorcontrib>Inane, Nevsun</creatorcontrib><title>Cardiovascular risk assessment after anti-TNF treatment in patients with rheumatoid arthritis and ankylosing spondylitis with Strain Echocardiography/Romatoid artrit ve ankilozan spondilit hastalarinda anti-TNF tedavisi sonrasi Strain Echo ile kardiyovaskuler risk degerlendirmesi</title><title>Journal of Turkish Society for Rheumatology</title><description>Objective: The aim of this study was to investigate the effects of antitumor necrosis factor (anti-TNF) agents on myocardial function and cardiovascular risk factors in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients receiving anti-TNF agents for inflammatory arthritis for six months by using standard and speckle tracking echocardiography. Methods: The study was conducted on a group of 30 patients composed of 12 with RA and 18 with AS. Demographic, standard and speckle tracking echocardiographic data, disease activities, laboratory results related to our research were prospectively assessed. Results: In the study, there was a statistically significant decrease in disease activity score, Bath Ankylosing Spondylitis Disease Activity index, Health Assessment Questionnaire, and Bath Ankylosing Spondylitis Functional Index scores and erythrocyte sedimentation rate, C-reactive protein values of patients with RA and AS in the sixth month of anti-TNF treatment. There was a decrease in left ventricular global longitudinal strain values assessed with speckle tracking echocardiography in the sixth month compared to the baseline and this difference was statistically significant. Conclusion: Myocardial strain imaging might be useful in assessing the early development of cardiac failure in patients with high cardiovascular risk, such as patients with RA and AS. Keywords: Tumor necrosis factor antagonist, cardiovascular risk, rheumatoid arthritis, ankylosing spondylitis Amac: Calismanin amaci, romatoid artrit (RA) ve ankilozan spondilit (AS) hastalarinda, alti ay sureyle anti-tumor nekroz faktoru (anti-TNF) ku llanim in in miyokard fonksiyonu ve kardiyovaskuler risk faktorleri uzerindeki etkilerini standart ve speckle tracking ekokardiyografi kullanarak arastirmaktir. Yontem: Calismaya 12 RA ve 18 AS olmak uzere toplam 30 hasta dahil edildi. Arastirmamizla ilgili demografik, standart ve speckle tracking ekokardiyografik veriler, hastalik aktiviteleri, laboratuvar sonuclari prospektif olarak degerlendirildi. Bulgular: Calismada anti-TNF tedavisinin altinci ayinda RA ve AS'li hastalarin hastalik aktivite skoru, Bath Ankilozan Spondilit Hastalik Aktivite indeksi, Saglik Degerlendirme Anketi ve Bath Ankilozan Spondilit Fonksiyonel indeksi skorlarinda ve eritrosit sedimentasyon hizinda, C-reaktif protein degerlerinde istatistiksel olarak anlamli dusus saptandi. Speckle tracking ekokardiyografi ile degerlendirilen sol ventrikul global longitudinal strain degerlerinde baslangica kiyasla altinci ayda istatistiksel olarak anlamli azalma oldugu saptandi. Sonuc: Miyokardiyal strain goruntulemesi RA ve AS'li hastalar gibi yuksek kardiyovaskuler riski olan hastalarda kalp yetmezliginin erken gelisimini degerlendirmede yararli olabilir. Anahtar Kelimeler: Tumor nekroz faktor antagonist, kardiyovaskuler risk, romatoid artrit, ankilozan spondilit</description><subject>Ankylosing spondylitis</subject><subject>Antiarthritic agents</subject><subject>Blood</subject><subject>Care and treatment</subject><subject>Heart failure</subject><subject>Medical examination</subject><subject>Rheumatoid factor</subject><subject>Risk assessment</subject><subject>Tumor necrosis factor</subject><issn>2651-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkd9rGzEMx6-wQUvX977VsOdc7TvfjzyW0G6DssGW96LzyXda7uxgORnpXz8nLSwPw2DJSProKznL7pTMddHo-wDY5wNM6DznhSyKvKgarT9kV0VdqUW6ysvshvm3lLJoq7qW8uridgWhJ78HNrsJggjEGwHMyDyjiwJsxCDARVqsvz-JGBDiKUBObCFScln8oTiKMOJuhuipFxDiGCgSp8L0cpvD5JncIHjrXX-YTqFT0a8YIJEezejNScgQYDse7n_6f6hEEns8Ymjyr-DeKJQoYgSOkGST6-FMJPawJybB3gVI9qyLoAnF5tjqcBx6s5vwfegeBwxpeT2FGZk-ZR8tTIw37_Y6Wz89rldfF88_vnxbPTwvhrpJS7VtWUJrGq2gRtN1tjJtq2SJSnfQSOjapoBOt7JTRi3bpS21lmihk0tru6q8zj6_YY8f90LO-qTVzMTm5aEpS123SquUlf8nK50eZzLeoU1jnRf8Bf_fr9A</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Yonak, Asli Karadeniz</creator><creator>Dayan, Akin</creator><creator>Ozen, Gulsen</creator><creator>Sunbul, Murat</creator><creator>Atagunduz, Mehmet Pamir</creator><creator>Inane, Nevsun</creator><general>Galenos Yayinevi Tic. 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Methods: The study was conducted on a group of 30 patients composed of 12 with RA and 18 with AS. Demographic, standard and speckle tracking echocardiographic data, disease activities, laboratory results related to our research were prospectively assessed. Results: In the study, there was a statistically significant decrease in disease activity score, Bath Ankylosing Spondylitis Disease Activity index, Health Assessment Questionnaire, and Bath Ankylosing Spondylitis Functional Index scores and erythrocyte sedimentation rate, C-reactive protein values of patients with RA and AS in the sixth month of anti-TNF treatment. There was a decrease in left ventricular global longitudinal strain values assessed with speckle tracking echocardiography in the sixth month compared to the baseline and this difference was statistically significant. Conclusion: Myocardial strain imaging might be useful in assessing the early development of cardiac failure in patients with high cardiovascular risk, such as patients with RA and AS. Keywords: Tumor necrosis factor antagonist, cardiovascular risk, rheumatoid arthritis, ankylosing spondylitis Amac: Calismanin amaci, romatoid artrit (RA) ve ankilozan spondilit (AS) hastalarinda, alti ay sureyle anti-tumor nekroz faktoru (anti-TNF) ku llanim in in miyokard fonksiyonu ve kardiyovaskuler risk faktorleri uzerindeki etkilerini standart ve speckle tracking ekokardiyografi kullanarak arastirmaktir. Yontem: Calismaya 12 RA ve 18 AS olmak uzere toplam 30 hasta dahil edildi. Arastirmamizla ilgili demografik, standart ve speckle tracking ekokardiyografik veriler, hastalik aktiviteleri, laboratuvar sonuclari prospektif olarak degerlendirildi. Bulgular: Calismada anti-TNF tedavisinin altinci ayinda RA ve AS'li hastalarin hastalik aktivite skoru, Bath Ankilozan Spondilit Hastalik Aktivite indeksi, Saglik Degerlendirme Anketi ve Bath Ankilozan Spondilit Fonksiyonel indeksi skorlarinda ve eritrosit sedimentasyon hizinda, C-reaktif protein degerlerinde istatistiksel olarak anlamli dusus saptandi. Speckle tracking ekokardiyografi ile degerlendirilen sol ventrikul global longitudinal strain degerlerinde baslangica kiyasla altinci ayda istatistiksel olarak anlamli azalma oldugu saptandi. Sonuc: Miyokardiyal strain goruntulemesi RA ve AS'li hastalar gibi yuksek kardiyovaskuler riski olan hastalarda kalp yetmezliginin erken gelisimini degerlendirmede yararli olabilir. Anahtar Kelimeler: Tumor nekroz faktor antagonist, kardiyovaskuler risk, romatoid artrit, ankilozan spondilit</abstract><pub>Galenos Yayinevi Tic. Ltd</pub><doi>10.4274/raed.galenos.2022.25744</doi></addata></record>
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subjects Ankylosing spondylitis
Antiarthritic agents
Blood
Care and treatment
Heart failure
Medical examination
Rheumatoid factor
Risk assessment
Tumor necrosis factor
title Cardiovascular risk assessment after anti-TNF treatment in patients with rheumatoid arthritis and ankylosing spondylitis with Strain Echocardiography/Romatoid artrit ve ankilozan spondilit hastalarinda anti-TNF tedavisi sonrasi Strain Echo ile kardiyovaskuler risk degerlendirmesi
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