Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?

Abstract Introduction: Heparin sulphate proteoglycans in the liver tumour microenvironment (TME) are key regulators of cell signalling, modulated by sulfatase-2 (SULF2). SULF2 overexpression occurs in hepatocellular carcinoma (HCC). Our aims were to define the nature and impact of SULF2 in the HCC T...

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Veröffentlicht in:	Liver cancer (Basel ) 2022-12, Vol.11 (6), p.540-557
Hauptverfasser:	Zaki, Marco Y.W., Alhasan, Sari F., Shukla, Ruchi, McCain, Misti, Laszczewska, Maja, Geh, Daniel, Patman, Gillian L., Televantou, Despina, Whitehead, Anna, Maurício, João P., Barksby, Ben, Gee, Lucy M., Paish, Hannah L., Leslie, Jack, Younes, Ramy, Burt, Alastair D., Borthwick, Lee A., Thomas, Huw, Beale, Gary S., Govaere, Olivier, Sia, Daniela, Anstee, Quentin M., Tiniakos, Dina, Oakley, Fiona, Reeves, Helen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Cancer Cancer therapies Cell culture Clinical outcomes Fibroblasts Gene expression Genetic aspects Genomes Hepatoma Immunohistochemistry Liver Liver cancer Liver cirrhosis Liver diseases Mitochondrial DNA Patients Penicillin Research Article Spheroids Targeted cancer therapy Transforming growth factors Type 2 diabetes
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