Therapeutic Potential of a Novel Vitamin D[sub.3] Oxime Analogue, VD1-6, with CYP24A1 Enzyme Inhibitory Activity and Negligible Vitamin D Receptor Binding

The regulation of vitamin D[sub.3] actions in humans occurs mainly through the Cytochrome P450 24-hydroxylase (CYP24A1) enzyme activity. CYP24A1 hydroxylates both 25-hydroxycholecalciferol (25(OH)D[sub.3]) and 1,25-dihydroxycholecalciferol (1,25(OH)[sub.2]D[sub.3]), which is the first step of vitami...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2022-07, Vol.12 (7)
Hauptverfasser:	Alshabrawy, Ali K, Cui, Yingjie, Sylvester, Cyan, Yang, Dongqing, Petito, Emilio S, Barratt, Kate R, Sawyer, Rebecca K, Heatlie, Jessica K, Polara, Ruhi, Sykes, Matthew J, Atkins, Gerald J, Hickey, Shane M, Wiese, Michael D, Stringer, Andrea M, Liu, Zhaopeng, Anderson, Paul H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alfacalcidol Analysis Calcifediol Care and treatment Chronic kidney failure Cytochrome P-450 Diagnosis Health aspects Measurement Risk factors Vitamin D
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!