Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl Is/I-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells Ivia/I EGFR/PI3K/AKT/mTOR Signaling Cascades

Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazi...

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Veröffentlicht in:	Pharmaceutics 2022-07, Vol.14 (8)
Hauptverfasser:	Shawish, Ihab, Barakat, Assem, Aldalbahi, Ali, Alshaer, Walhan, Daoud, Fadwa, Alqudah, Dana A, Al Zoubi, Mazhar, Hatmal, Ma’mon M, Nafie, Mohamed S, Haukka, Matti, Sharma, Anamika, de la Torre, Beatriz G, Albericio, Fernando, El-Faham, Ayman
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Dosage and administration Molecular targeted therapy Patient outcomes Pyrazoles
Online-Zugang:	Volltext
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