Denaturation and Aggregation of Interferon-[tau] in Aqueous Solution

Purpose To evaluate the different degrees of residual structure in the unfolded state of interferon-[tau] using chemical denaturation as a function of temperature by both urea and guanidinium hydrochloride. Methods Asymmetrical flow field-flow fractionation (AF4) using both UV and multi-angle laser...

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Veröffentlicht in:	Pharmaceutical research 2018-07, Vol.35 (7)
Hauptverfasser:	Manning, Ryan R, Wilson, Glenn A, Holcomb, Ryan E, Zbacnik, Nathaniel J, Tellechea, Auria A, Gilley-Dunn, Chelsey L, Krammes, Ryan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological response modifiers Denaturation Histidine Imaging systems Interferon Proteins Urea
Online-Zugang:	Volltext
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