Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of [beta]-catenin pathway

Paclitaxel is one of the most commonly used drugs for the treatment of nonsmall cell lung cancer (NSCLC). However acquired resistance to paclitaxel, epithelial to mesenchymal transition and cancer stem cell formation are the major obstacles for successful chemotherapy with this drug. Some of the maj...

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Veröffentlicht in:	Apoptosis (London) 2019-06, Vol.24 (5-6), p.414
Hauptverfasser:	Datta, Satabdi, Choudhury, Diptiman, Das, Amlan, Mukherjee, Dipanwita Das, Dasgupta, Moumita, Bandopadhyay, Shreya, Chakraba
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Cancer Chemotherapy Ethylenediaminetetraacetic acid Lung cancer, Non-small cell Metastasis Stem cells Tubulins
Online-Zugang:	Volltext
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