The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome/Polikistik over sendromunun patofizyolojisinde enflamasyon, oksidasyon ve Sistatin-C'nin rolu
Objective: The relationship between Cystatin-C levels and inflammatory, oxidant, and antioxidant markers in polycystic ovary syndrome (PCOS) was investigated. Materials and Methods: A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-...
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| Veröffentlicht in: | Turkish journal of obstetrics and gynecology 2022-09, Vol.19 (3), p.229 |
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| description | Objective: The relationship between Cystatin-C levels and inflammatory, oxidant, and antioxidant markers in polycystic ovary syndrome (PCOS) was investigated. Materials and Methods: A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-alpha (TNF-[alpha]), interleukin-1 beta (IL-1B), interleukin 6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), and Cystatin-C were evaluated by ELISA method. Relationships metabolic and endocrine parameters seen in PCOS were examined. Univariate and multivariate logistic regression analyzes were performed to identify risk factors that may affect the PCOS group. Bivariate correlations were investigated by the Spearman's correlation analysis. Results: While Cystatin-c, TNF-[alpha], IL-1B, IL-6, MDA were found to be higher in patients with PCOS compared with the control group, SOD was found to be lower than the control group (p |
| doi_str_mv | 10.4274/tjod.galenos.2022.29498 |
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Materials and Methods: A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-alpha (TNF-[alpha]), interleukin-1 beta (IL-1B), interleukin 6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), and Cystatin-C were evaluated by ELISA method. Relationships metabolic and endocrine parameters seen in PCOS were examined. Univariate and multivariate logistic regression analyzes were performed to identify risk factors that may affect the PCOS group. Bivariate correlations were investigated by the Spearman's correlation analysis. Results: While Cystatin-c, TNF-[alpha], IL-1B, IL-6, MDA were found to be higher in patients with PCOS compared with the control group, SOD was found to be lower than the control group (p<0.05). In the correlation analysis, increased Cystatin-C levels were found to be associated with high IL-6 (r=0.214, p=0.037) and low SOD levels (r=-0.280, p=0.006). Conclusion: In our study, it was found that the increase in Cystatin-C levels was associated with an increase in IL-6 and a decrease in SOD. These results may bring up different treatment options to reduce cardiovascular risks for treating PCOS. Keywords: Polycystic ovary syndrome, Cystatin-C, interleukin, oxidation, superoxide dismutase Amac: Polikistik over sendromunda (PKOS) Sistatin-C duzeyleri ile enflamatuvar, oksidan ve antioksidan belirtecler arasindaki iliskinin arastirilmasi amaclandi. Gerec ve Yontemler: Calismaya PKOS (n=58) ve kontrol (n=38) grubu olarak toplam 96 katilimci dahil edildi. Tumor nekroz faktor-alfa (TNF-[alpha]), interlokin-1 beta (IL-1B), interlokin 6 (IL-6), malondialdehit (MDA), superoksit dismutaz (SOD) ve Sistatin-C markerlari ELISA yontemi ile degerlendirildi. PKOS grubunu etkileyebilecek olasi risk faktorlerini belirlemek icin tek degiskenli ve cok degiskenli lojistik regresyon analizi yapildi. Iki degiskenli korelasyonlar Spearman korelasyon analizi ile arastirildi. Bulgular: PKOS hastalarinda Sistatin-C, TNF-[alpha], IL-1B, IL-6, MDA, kontrol grubuna gore daha anlamli olarak yuksek bulunurken, kontrol grubunda SOD daha yuksek bulundu (p<0,05). Korelasyon analizinde, artan Sistatin-C seviyeleri, yuksek IL-6 (r=0,214, p=0,037) ve dusuk SOD seviyeleri (r=-0,280, p=0,006) ile iliskili bulundu. Sonuc: Calismamizda kardiyovaskuler hastalik belirteci olan Sistatin-C duzeylerindeki artisin yuksek IL-6 ve dusuk SOD seviyeleri ile iliskili oldugu bulundu. Bu sonuclar PKOS tedavisinde kardiyovaskuler riskleri azaltmak icin farkh tedavi seceneklerini gundeme getirebilir. Anahtar Kelimeler: Polikistik over sendromu, Sistatin-C, interlokin, oksidasyon, superoksit dismutaz</description><identifier>ISSN: 2149-9322</identifier><identifier>DOI: 10.4274/tjod.galenos.2022.29498</identifier><language>eng</language><publisher>Galenos Yayinevi Tic. Ltd</publisher><subject>Complications and side effects ; Development and progression ; Health aspects ; Interleukin-6 ; Measurement ; Physiological aspects ; Stein-Leventhal syndrome ; Superoxide dismutase</subject><ispartof>Turkish journal of obstetrics and gynecology, 2022-09, Vol.19 (3), p.229</ispartof><rights>COPYRIGHT 2022 Galenos Yayinevi Tic. Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Baser, Ozden Ozdemir</creatorcontrib><creatorcontrib>Gocmen, Ayse Yesim</creatorcontrib><creatorcontrib>Kirmizi, Demet Aydogan</creatorcontrib><title>The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome/Polikistik over sendromunun patofizyolojisinde enflamasyon, oksidasyon ve Sistatin-C'nin rolu</title><title>Turkish journal of obstetrics and gynecology</title><description>Objective: The relationship between Cystatin-C levels and inflammatory, oxidant, and antioxidant markers in polycystic ovary syndrome (PCOS) was investigated. Materials and Methods: A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-alpha (TNF-[alpha]), interleukin-1 beta (IL-1B), interleukin 6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), and Cystatin-C were evaluated by ELISA method. Relationships metabolic and endocrine parameters seen in PCOS were examined. Univariate and multivariate logistic regression analyzes were performed to identify risk factors that may affect the PCOS group. Bivariate correlations were investigated by the Spearman's correlation analysis. Results: While Cystatin-c, TNF-[alpha], IL-1B, IL-6, MDA were found to be higher in patients with PCOS compared with the control group, SOD was found to be lower than the control group (p<0.05). In the correlation analysis, increased Cystatin-C levels were found to be associated with high IL-6 (r=0.214, p=0.037) and low SOD levels (r=-0.280, p=0.006). Conclusion: In our study, it was found that the increase in Cystatin-C levels was associated with an increase in IL-6 and a decrease in SOD. These results may bring up different treatment options to reduce cardiovascular risks for treating PCOS. Keywords: Polycystic ovary syndrome, Cystatin-C, interleukin, oxidation, superoxide dismutase Amac: Polikistik over sendromunda (PKOS) Sistatin-C duzeyleri ile enflamatuvar, oksidan ve antioksidan belirtecler arasindaki iliskinin arastirilmasi amaclandi. Gerec ve Yontemler: Calismaya PKOS (n=58) ve kontrol (n=38) grubu olarak toplam 96 katilimci dahil edildi. Tumor nekroz faktor-alfa (TNF-[alpha]), interlokin-1 beta (IL-1B), interlokin 6 (IL-6), malondialdehit (MDA), superoksit dismutaz (SOD) ve Sistatin-C markerlari ELISA yontemi ile degerlendirildi. PKOS grubunu etkileyebilecek olasi risk faktorlerini belirlemek icin tek degiskenli ve cok degiskenli lojistik regresyon analizi yapildi. Iki degiskenli korelasyonlar Spearman korelasyon analizi ile arastirildi. Bulgular: PKOS hastalarinda Sistatin-C, TNF-[alpha], IL-1B, IL-6, MDA, kontrol grubuna gore daha anlamli olarak yuksek bulunurken, kontrol grubunda SOD daha yuksek bulundu (p<0,05). Korelasyon analizinde, artan Sistatin-C seviyeleri, yuksek IL-6 (r=0,214, p=0,037) ve dusuk SOD seviyeleri (r=-0,280, p=0,006) ile iliskili bulundu. Sonuc: Calismamizda kardiyovaskuler hastalik belirteci olan Sistatin-C duzeylerindeki artisin yuksek IL-6 ve dusuk SOD seviyeleri ile iliskili oldugu bulundu. Bu sonuclar PKOS tedavisinde kardiyovaskuler riskleri azaltmak icin farkh tedavi seceneklerini gundeme getirebilir. Anahtar Kelimeler: Polikistik over sendromu, Sistatin-C, interlokin, oksidasyon, superoksit dismutaz</description><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Interleukin-6</subject><subject>Measurement</subject><subject>Physiological aspects</subject><subject>Stein-Leventhal syndrome</subject><subject>Superoxide dismutase</subject><issn>2149-9322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkMtOwzAQRb0AiarwDVhiwYakifP0sqp4SZVAovvKscet28RTxWlF-D4-DCeAxALNYsa-d66OhpDrOApTVqSzbocq3IgaLLqQRYyFjKe8PCMTFqc84AljF-TKuV0URXFZFDxmE_K52gJtsQaKmhqra9E0ojNo7yi-GzWOVFhFF73r_MsGC2-jnd86iG6Lh23vDNa46YeAA9a99EYjKZ5E21PXW9ViA7NXrM3eeGXvFWipg1E42qMdglCbj97H7IwzVgGFkUS4fgTZO08yzPQE9M38gtxaT-LZj5fkXIvawdVPn5LVw_1q8RQsXx6fF_NlsMmLMpB5AnEEmqdZVaWQKw2SJUoxlpZQcgmgRJTmRZVlOtJxKWKlJAelBVSVyCCZkpvv2OHIa38s7FohG-Pkel4wlsQ5y0rvCv9x-VLQGIkWtPH_fxa-AHAhkhQ</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Baser, Ozden Ozdemir</creator><creator>Gocmen, Ayse Yesim</creator><creator>Kirmizi, Demet Aydogan</creator><general>Galenos Yayinevi Tic. Ltd</general><scope/></search><sort><creationdate>20220901</creationdate><title>The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome/Polikistik over sendromunun patofizyolojisinde enflamasyon, oksidasyon ve Sistatin-C'nin rolu</title><author>Baser, Ozden Ozdemir ; Gocmen, Ayse Yesim ; Kirmizi, Demet Aydogan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g678-c63e10ef945bb4e6dfec23dd2248e89ceeda0467b55f0f18a1ddc9edfaebba5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Health aspects</topic><topic>Interleukin-6</topic><topic>Measurement</topic><topic>Physiological aspects</topic><topic>Stein-Leventhal syndrome</topic><topic>Superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baser, Ozden Ozdemir</creatorcontrib><creatorcontrib>Gocmen, Ayse Yesim</creatorcontrib><creatorcontrib>Kirmizi, Demet Aydogan</creatorcontrib><jtitle>Turkish journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baser, Ozden Ozdemir</au><au>Gocmen, Ayse Yesim</au><au>Kirmizi, Demet Aydogan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome/Polikistik over sendromunun patofizyolojisinde enflamasyon, oksidasyon ve Sistatin-C'nin rolu</atitle><jtitle>Turkish journal of obstetrics and gynecology</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>19</volume><issue>3</issue><spage>229</spage><pages>229-</pages><issn>2149-9322</issn><abstract>Objective: The relationship between Cystatin-C levels and inflammatory, oxidant, and antioxidant markers in polycystic ovary syndrome (PCOS) was investigated. Materials and Methods: A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-alpha (TNF-[alpha]), interleukin-1 beta (IL-1B), interleukin 6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), and Cystatin-C were evaluated by ELISA method. Relationships metabolic and endocrine parameters seen in PCOS were examined. Univariate and multivariate logistic regression analyzes were performed to identify risk factors that may affect the PCOS group. Bivariate correlations were investigated by the Spearman's correlation analysis. Results: While Cystatin-c, TNF-[alpha], IL-1B, IL-6, MDA were found to be higher in patients with PCOS compared with the control group, SOD was found to be lower than the control group (p<0.05). In the correlation analysis, increased Cystatin-C levels were found to be associated with high IL-6 (r=0.214, p=0.037) and low SOD levels (r=-0.280, p=0.006). Conclusion: In our study, it was found that the increase in Cystatin-C levels was associated with an increase in IL-6 and a decrease in SOD. These results may bring up different treatment options to reduce cardiovascular risks for treating PCOS. Keywords: Polycystic ovary syndrome, Cystatin-C, interleukin, oxidation, superoxide dismutase Amac: Polikistik over sendromunda (PKOS) Sistatin-C duzeyleri ile enflamatuvar, oksidan ve antioksidan belirtecler arasindaki iliskinin arastirilmasi amaclandi. Gerec ve Yontemler: Calismaya PKOS (n=58) ve kontrol (n=38) grubu olarak toplam 96 katilimci dahil edildi. Tumor nekroz faktor-alfa (TNF-[alpha]), interlokin-1 beta (IL-1B), interlokin 6 (IL-6), malondialdehit (MDA), superoksit dismutaz (SOD) ve Sistatin-C markerlari ELISA yontemi ile degerlendirildi. PKOS grubunu etkileyebilecek olasi risk faktorlerini belirlemek icin tek degiskenli ve cok degiskenli lojistik regresyon analizi yapildi. Iki degiskenli korelasyonlar Spearman korelasyon analizi ile arastirildi. Bulgular: PKOS hastalarinda Sistatin-C, TNF-[alpha], IL-1B, IL-6, MDA, kontrol grubuna gore daha anlamli olarak yuksek bulunurken, kontrol grubunda SOD daha yuksek bulundu (p<0,05). Korelasyon analizinde, artan Sistatin-C seviyeleri, yuksek IL-6 (r=0,214, p=0,037) ve dusuk SOD seviyeleri (r=-0,280, p=0,006) ile iliskili bulundu. Sonuc: Calismamizda kardiyovaskuler hastalik belirteci olan Sistatin-C duzeylerindeki artisin yuksek IL-6 ve dusuk SOD seviyeleri ile iliskili oldugu bulundu. Bu sonuclar PKOS tedavisinde kardiyovaskuler riskleri azaltmak icin farkh tedavi seceneklerini gundeme getirebilir. Anahtar Kelimeler: Polikistik over sendromu, Sistatin-C, interlokin, oksidasyon, superoksit dismutaz</abstract><pub>Galenos Yayinevi Tic. Ltd</pub><doi>10.4274/tjod.galenos.2022.29498</doi></addata></record> |
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| source | PubMed Central; Alma/SFX Local Collection |
| subjects | Complications and side effects Development and progression Health aspects Interleukin-6 Measurement Physiological aspects Stein-Leventhal syndrome Superoxide dismutase |
| title | The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome/Polikistik over sendromunun patofizyolojisinde enflamasyon, oksidasyon ve Sistatin-C'nin rolu |
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