Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through K.sub.v7.4 channel upsurge in auditory neurons and hair cells

Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that recognizes neuron-restrictive silencer elements in the mammalian genomes in a tissue- and cell-specific manner. The identity of REST target genes and molecular details of how REST regulates them are emergin...

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Veröffentlicht in:	eLife 2022-09, Vol.11
Hauptverfasser:	Zhang, Haiwei, Li, Hongchen, Lu, Mingshun, Wang, Shengnan, Ma, Xueya, Wang, Fei, Liu, Jiaxi, Li, Xinyu, Yang, Haichao, Zhang, Fan, Shen, Haitao, Buckley, Noel J, Gamper, Nikita, Yamoah, Ebenezer N, Lv, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetics Deafness Genetic research Hearing loss Neurons Somatotropin
Online-Zugang:	Volltext
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