Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human [alpha]-synuclein

In multiple system atrophy (MSA), the protein [alpha]-synuclein misfolds into a prion conformation that self-templates and causes progressive neurodegeneration. While many point mutations in the [alpha]-synuclein gene, SNCA, have been identified as the cause of heritable Parkinson's disease (PD...

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Veröffentlicht in:	Acta neuropathologica 2022-10, Vol.144 (4), p.677
Hauptverfasser:	Holec, Sara A. M, Lee, Jisoo, Oehler, Abby, Ooi, Felicia K, Mordes, Daniel A, Olson, Steven H, Prusiner, Stanley B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Atrophy Brain Gene mutations Genetic aspects Nervous system diseases
Online-Zugang:	Volltext
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