Maternal Environmental Exposure, Infant GSTP1 Polymorphism, and Risk of Isolated Congenital Heart Disease

The GSTP1 gene, highly expressed early in fetal life, is the most abundant phase 2 xenobiotic metabolism enzyme in a human placenta. Fetal inherited GSTP1 Ile105Val polymorphism may modify the metabolism and excretion of xenobiotics from fetal tissue and increase the risk of congenital heart disease...

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Veröffentlicht in:	Pediatric cardiology 2013-02, Vol.34 (2), p.281-285
Hauptverfasser:	Cresci, Monica, Foffa, Ilenia, Ait-Ali, Lamia, Pulignani, Silvia, Kemeny, Alessandra, Gianicolo, Emilio Antonio Luca, Andreassi, Maria Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cardiac Surgery Cardiology Child, Preschool Children Confidence Intervals Congenital heart disease DNA - genetics Environmental Exposure - adverse effects Enzymes Female Fetal Diseases - epidemiology Fetal Diseases - etiology Fetal Diseases - genetics Follow-Up Studies Genetic aspects Genetic disorders Genetic polymorphisms Genotype Glutathione S-Transferase pi - genetics Health aspects Heart Defects, Congenital - epidemiology Heart Defects, Congenital - etiology Heart Defects, Congenital - genetics Heart diseases Humans Infant Infant, Newborn Infants (Newborn) Italy - epidemiology Male Maternal Exposure - adverse effects Medical research Medicine Medicine & Public Health Medicine, Experimental Odds Ratio Original Article Physiological aspects Polymerase Chain Reaction Polymorphism, Genetic Pregnancy Retrospective Studies Risk Factors Surveys and Questionnaires Vascular Surgery Xenobiotics
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