Surface enhanced Raman detection of the colon cancer biomarker cytidine by using magnetized nanoparticles of the type Fe.sub.3O.sub.4/Au/Ag

Surface enhanced Raman detection of the colon cancer biomarker cytidine by using magnetized nanoparticles of the type Fe.sub.3O.sub.4/Au/Ag

Cytidine is regarded as an early marker of colon cancer. The authors describe a surface enhanced Raman scattering (SERS) technique to detect trace levels of cytidine in urine. The Raman band at 784 cm.sup.-1 can be acquired best. Compared to earlier methods, an improvement in detection sensitivity b...

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Veröffentlicht in:Mikrochimica acta (1966) 2018-03, Vol.185 (3)
Hauptverfasser: Xiang, Yuan, Yang, Hanru, Guo, Xiaoyu, Wu, Yiping, Ying, Ye, Wen, Ying, Yang, Haifeng
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Sprache:eng
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Cancer
Colon cancer
Diagnosis
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container_title Mikrochimica acta (1966)
container_volume 185
creator Xiang, Yuan
Yang, Hanru
Guo, Xiaoyu
Wu, Yiping
Ying, Ye
Wen, Ying
Yang, Haifeng
description Cytidine is regarded as an early marker of colon cancer. The authors describe a surface enhanced Raman scattering (SERS) technique to detect trace levels of cytidine in urine. The Raman band at 784 cm.sup.-1 can be acquired best. Compared to earlier methods, an improvement in detection sensitivity by a factor of 6.2 x 10.sup.5 is achieved by using a magnetically induced method in which cytidine is captured in the vicinity of the SERS hot spots of the type Fe.sub.3O.sub.4/Au/Ag. Cytidine can be quantified at 1 nM levels by this method which is simple and reliable.
doi_str_mv 10.1007/s00604-017-2666-5
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subjects Cancer
Colon cancer
Diagnosis
title Surface enhanced Raman detection of the colon cancer biomarker cytidine by using magnetized nanoparticles of the type Fe.sub.3O.sub.4/Au/Ag
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