Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways

Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways

Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor. Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to exhibit the inhibitory effect on a variety of tumors. Herein, we have evaluated the nature of the effect of plantamajoside on MOLM-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current topics in nutraceuticals research 2022-08, Vol.20 (3), p.513
Hauptverfasser: Zhou, Xiaolu, Wang, Guochuan, Wu, Qiongsheng, Yang, Mei
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Growth
Non-Hodgkin's lymphomas
Protein kinases
Proteins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 3
container_start_page 513
container_title Current topics in nutraceuticals research
container_volume 20
creator Zhou, Xiaolu
Wang, Guochuan
Wu, Qiongsheng
Yang, Mei
description Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor. Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to exhibit the inhibitory effect on a variety of tumors. Herein, we have evaluated the nature of the effect of plantamajoside on MOLM-13 and HL-60 cells--two acute myeloid leukemia cells--by measuring parameters such as cell viability, proliferation, apoptosis rate, cell cycle arrest, and relative expression of BCL2-associated X protein, B-cell lymphoma 2 protein, cleaved-caspase-3, protein kinase B, and p65 proteins. These measurements led us to conclude that plantamajoside suppresses the proliferation of both MOLM-13 and HL-60 cells via inhibiting nuclear factor-kappa B and phosphatidylinositol 3-kinase/protein kinase axis in a dose-dependent fashion. Keywords: Acute myeloid leukemia, Growth, NF-[kappa]B, PI3K/AKT, Plantamajoside
doi_str_mv 10.37290/ctnr2641-452X.20:513-519
format Article
fullrecord <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A713670668</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A713670668</galeid><sourcerecordid>A713670668</sourcerecordid><originalsourceid>FETCH-LOGICAL-g988-a794bf19c0c76b769c174fbf98f23c6a1f48061de26946c5d9f5aaf2d12199743</originalsourceid><addsrcrecordid>eNptj0FLwzAcxXtQcE6_Q0Tw1pmkbdJ4m8PpcOrAHQSR8W-atNEsGUuKDPzwVvSgIO_w4PF7D16SnBA8yjgV-FxGt6UsJ2le0KcRxRcFydKCiL1kQIocp7zIioPkMIRXjFlGSzpIPhYWXIQ1vPpgaoVmrjWViQHFVqHrrX-PLfIajWUXFbrbKetNjeaqe1NrA2iirA2o2qE7X3cWonENup-mz2-w2cDLJQJXo8Usuz0f3y7Ro2kc2C9kAbF9h104SvY12KCOf3yYLKdXy8lNOn-4nk3G87QRZZkCF3mliZBYclZxJiThua60KDXNJAOi8xIzUivKRM5kUQtdAGhaE0qE4Hk2TE6_ZxuwamWc9nELcm2CXI05yRjHjJU9NfqH6lX3V6V3Sps-_1M4-1VoFdjYBm-7aLwLv8FPfdh8Zw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways</title><source>EBSCOhost Business Source Complete</source><creator>Zhou, Xiaolu ; Wang, Guochuan ; Wu, Qiongsheng ; Yang, Mei</creator><creatorcontrib>Zhou, Xiaolu ; Wang, Guochuan ; Wu, Qiongsheng ; Yang, Mei</creatorcontrib><description>Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor. Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to exhibit the inhibitory effect on a variety of tumors. Herein, we have evaluated the nature of the effect of plantamajoside on MOLM-13 and HL-60 cells--two acute myeloid leukemia cells--by measuring parameters such as cell viability, proliferation, apoptosis rate, cell cycle arrest, and relative expression of BCL2-associated X protein, B-cell lymphoma 2 protein, cleaved-caspase-3, protein kinase B, and p65 proteins. These measurements led us to conclude that plantamajoside suppresses the proliferation of both MOLM-13 and HL-60 cells via inhibiting nuclear factor-kappa B and phosphatidylinositol 3-kinase/protein kinase axis in a dose-dependent fashion. Keywords: Acute myeloid leukemia, Growth, NF-[kappa]B, PI3K/AKT, Plantamajoside</description><identifier>ISSN: 1540-7535</identifier><identifier>DOI: 10.37290/ctnr2641-452X.20:513-519</identifier><language>eng</language><publisher>New Century Health Publishers, LLC</publisher><subject>Apoptosis ; Growth ; Non-Hodgkin's lymphomas ; Protein kinases ; Proteins</subject><ispartof>Current topics in nutraceuticals research, 2022-08, Vol.20 (3), p.513</ispartof><rights>COPYRIGHT 2022 New Century Health Publishers, LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhou, Xiaolu</creatorcontrib><creatorcontrib>Wang, Guochuan</creatorcontrib><creatorcontrib>Wu, Qiongsheng</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><title>Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways</title><title>Current topics in nutraceuticals research</title><description>Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor. Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to exhibit the inhibitory effect on a variety of tumors. Herein, we have evaluated the nature of the effect of plantamajoside on MOLM-13 and HL-60 cells--two acute myeloid leukemia cells--by measuring parameters such as cell viability, proliferation, apoptosis rate, cell cycle arrest, and relative expression of BCL2-associated X protein, B-cell lymphoma 2 protein, cleaved-caspase-3, protein kinase B, and p65 proteins. These measurements led us to conclude that plantamajoside suppresses the proliferation of both MOLM-13 and HL-60 cells via inhibiting nuclear factor-kappa B and phosphatidylinositol 3-kinase/protein kinase axis in a dose-dependent fashion. Keywords: Acute myeloid leukemia, Growth, NF-[kappa]B, PI3K/AKT, Plantamajoside</description><subject>Apoptosis</subject><subject>Growth</subject><subject>Non-Hodgkin's lymphomas</subject><subject>Protein kinases</subject><subject>Proteins</subject><issn>1540-7535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj0FLwzAcxXtQcE6_Q0Tw1pmkbdJ4m8PpcOrAHQSR8W-atNEsGUuKDPzwVvSgIO_w4PF7D16SnBA8yjgV-FxGt6UsJ2le0KcRxRcFydKCiL1kQIocp7zIioPkMIRXjFlGSzpIPhYWXIQ1vPpgaoVmrjWViQHFVqHrrX-PLfIajWUXFbrbKetNjeaqe1NrA2iirA2o2qE7X3cWonENup-mz2-w2cDLJQJXo8Usuz0f3y7Ro2kc2C9kAbF9h104SvY12KCOf3yYLKdXy8lNOn-4nk3G87QRZZkCF3mliZBYclZxJiThua60KDXNJAOi8xIzUivKRM5kUQtdAGhaE0qE4Hk2TE6_ZxuwamWc9nELcm2CXI05yRjHjJU9NfqH6lX3V6V3Sps-_1M4-1VoFdjYBm-7aLwLv8FPfdh8Zw</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Zhou, Xiaolu</creator><creator>Wang, Guochuan</creator><creator>Wu, Qiongsheng</creator><creator>Yang, Mei</creator><general>New Century Health Publishers, LLC</general><scope/></search><sort><creationdate>20220801</creationdate><title>Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways</title><author>Zhou, Xiaolu ; Wang, Guochuan ; Wu, Qiongsheng ; Yang, Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g988-a794bf19c0c76b769c174fbf98f23c6a1f48061de26946c5d9f5aaf2d12199743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apoptosis</topic><topic>Growth</topic><topic>Non-Hodgkin's lymphomas</topic><topic>Protein kinases</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Xiaolu</creatorcontrib><creatorcontrib>Wang, Guochuan</creatorcontrib><creatorcontrib>Wu, Qiongsheng</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><jtitle>Current topics in nutraceuticals research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xiaolu</au><au>Wang, Guochuan</au><au>Wu, Qiongsheng</au><au>Yang, Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways</atitle><jtitle>Current topics in nutraceuticals research</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>20</volume><issue>3</issue><spage>513</spage><pages>513-</pages><issn>1540-7535</issn><abstract>Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor. Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to exhibit the inhibitory effect on a variety of tumors. Herein, we have evaluated the nature of the effect of plantamajoside on MOLM-13 and HL-60 cells--two acute myeloid leukemia cells--by measuring parameters such as cell viability, proliferation, apoptosis rate, cell cycle arrest, and relative expression of BCL2-associated X protein, B-cell lymphoma 2 protein, cleaved-caspase-3, protein kinase B, and p65 proteins. These measurements led us to conclude that plantamajoside suppresses the proliferation of both MOLM-13 and HL-60 cells via inhibiting nuclear factor-kappa B and phosphatidylinositol 3-kinase/protein kinase axis in a dose-dependent fashion. Keywords: Acute myeloid leukemia, Growth, NF-[kappa]B, PI3K/AKT, Plantamajoside</abstract><pub>New Century Health Publishers, LLC</pub><doi>10.37290/ctnr2641-452X.20:513-519</doi></addata></record>
fulltext fulltext
identifier ISSN: 1540-7535
ispartof Current topics in nutraceuticals research, 2022-08, Vol.20 (3), p.513
issn 1540-7535
language eng
recordid cdi_gale_infotracmisc_A713670668
source EBSCOhost Business Source Complete
subjects Apoptosis
Growth
Non-Hodgkin's lymphomas
Protein kinases
Proteins
title Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-[kappa]B and PI3K/AKT Signaling Pathways
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A05%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plantamajoside%20Inhibits%20the%20Growth%20of%20Acute%20Myeloid%20Leukemia%20Cells%20by%20Modulating%20NF-%5Bkappa%5DB%20and%20PI3K/AKT%20Signaling%20Pathways&rft.jtitle=Current%20topics%20in%20nutraceuticals%20research&rft.au=Zhou,%20Xiaolu&rft.date=2022-08-01&rft.volume=20&rft.issue=3&rft.spage=513&rft.pages=513-&rft.issn=1540-7535&rft_id=info:doi/10.37290/ctnr2641-452X.20:513-519&rft_dat=%3Cgale%3EA713670668%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A713670668&rfr_iscdi=true