Disrupting the DREAM complex enables proliferation of adult human pancreatic [beta] cells

Resistance to regeneration of insulin-producing pancreatic [beta] cells is a fundamental challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase DYRK1A have proven effective in inducing adult human [beta] cells to proliferate, but their detailed mechanism of actio...

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Veröffentlicht in:	The Journal of clinical investigation 2022-08, Vol.132 (15)
Hauptverfasser:	Wang, Peng, Karakose, Esra, Argmann, Carmen, Wang, Huan, Balev, Metodi, Brody, Rachel I, Rivas, Hembly G, Liu, Xinyue, Wood, Olivia, Liu, Hongtao, Choleva, Lauryn, Hasson, Dan, Bernstein, Emily, Paulo, Joao A, Scott, Donald K, Lambertini, Luca, DeCaprio, James A, Stewart, Andrew F
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding proteins Development and progression Diabetes Health aspects Pancreatic beta cells Physiological aspects Protein kinases
Online-Zugang:	Volltext
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