HIF-1[alpha] induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury

Cellular metabolism is a critical regulator of macrophage effector function. Tissue-resident alveolar macrophages (TR-AMs) inhabit a unique niche marked by high oxygen and low glucose. We have recently shown that in contrast to bone marrow-derived macrophages (BMDMs), TR-AMs do not utilize glycolysi...

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Veröffentlicht in:	eLife 2022-07, Vol.11
Hauptverfasser:	Woods, Parker S, Kimmig, Lucas M, Sun, Kaitlyn A, Meliton, Angelo Y, Shamaa, Obada R, Tian, Yufeng, Cetin-Atalay, Rengül, Sharp, Willard W, Hamanaka, Robert B, Mutlu, Gökhan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute respiratory distress syndrome Canada Health aspects Inflammation Macrophages Metabolites Mortality United Kingdom
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