Endophenotypes as a measure of suicidality
Suicide is thought to result from the harmful interaction of multiple factors that have social, environmental, neurobiological, and genetic backgrounds. Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disor...
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| Veröffentlicht in: | Journal of applied genetics 2012-11, Vol.53 (4), p.389-413 |
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| container_title | Journal of applied genetics |
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| creator | Chistiakov, Dimitry A. Kekelidze, Zurab I. Chekhonin, Vladimir P. |
| description | Suicide is thought to result from the harmful interaction of multiple factors that have social, environmental, neurobiological, and genetic backgrounds. Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia, or alcohol dependence. Given the suicidal behavior heterogeneity and its hereditary complexity, the need to find demonstrable intermediate phenotypes that may make it possible to establish links between genes and suicide behaviors (endophenotypes) seems to be necessary. The main objective of this review was to consider the candidate endophenotypes of suicidal behaviors. Due to the recent advances in neuroimaging, we also characterize brain regions implicated in vulnerability to suicide behavior that are influenced by gene polymorphisms associated with suicidal behavior. |
| doi_str_mv | 10.1007/s13353-012-0113-1 |
| format | Article |
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Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia, or alcohol dependence. Given the suicidal behavior heterogeneity and its hereditary complexity, the need to find demonstrable intermediate phenotypes that may make it possible to establish links between genes and suicide behaviors (endophenotypes) seems to be necessary. The main objective of this review was to consider the candidate endophenotypes of suicidal behaviors. 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Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia, or alcohol dependence. Given the suicidal behavior heterogeneity and its hereditary complexity, the need to find demonstrable intermediate phenotypes that may make it possible to establish links between genes and suicide behaviors (endophenotypes) seems to be necessary. The main objective of this review was to consider the candidate endophenotypes of suicidal behaviors. Due to the recent advances in neuroimaging, we also characterize brain regions implicated in vulnerability to suicide behavior that are influenced by gene polymorphisms associated with suicidal behavior.</description><subject>Alcoholism</subject><subject>Alleles</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Endophenotypes - analysis</subject><subject>Endophenotypes - metabolism</subject><subject>Epigenesis, Genetic</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Human Genetics</subject><subject>Human Genetics • Review</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - cerebrospinal fluid</subject><subject>Impulsive Behavior - genetics</subject><subject>Impulsive Behavior - psychology</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Neurophysiology</subject><subject>Plant Genetics and Genomics</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins - metabolism</subject><subject>Suicidal behavior</subject><subject>Suicide</subject><subject>Suicide - psychology</subject><subject>Tryptophan Hydroxylase - genetics</subject><subject>Tryptophan Hydroxylase - metabolism</subject><issn>1234-1983</issn><issn>2190-3883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotlYfwI0MuBOm5uTSJMtSWhUKbnQdMplMTelcSGYWfXtTRgVBJCeEnPzfIXwI3QKeA8biMQKlnOYYSNpAczhDUwIK51RKeo6mQCjLQUk6QVcx7jGmkglyiSaEKAYc-BQ9rJuy7T5c0_bHzsXMpMpqZ-IQXNZWWRy89aU5-P54jS4qc4ju5uucoffN-m31nG9fn15Wy21uGUCfK6yEsAqnn0lrhVqodFkUHEAVSmAqiGFSloCdVZY5JbillnELFriSrKAzdD_O3ZmD076p2j4YW_to9VIAFkwtuEqp-R-ptEpXe9s2rvKp_wuAEbChjTG4SnfB1yYcNWB90qlHnTrp1CedGhJzNzLdUNSu_CG-_aUAGQMxPTU7F_S-HUKT9Pwz9RPUUXv1</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Chistiakov, Dimitry A.</creator><creator>Kekelidze, Zurab I.</creator><creator>Chekhonin, Vladimir P.</creator><general>Springer-Verlag</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20121101</creationdate><title>Endophenotypes as a measure of suicidality</title><author>Chistiakov, Dimitry A. ; Kekelidze, Zurab I. ; Chekhonin, Vladimir P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-90977c903538cc7969c906b5119b970372a488d10ec9c4e975c3c45c1c15984b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alcoholism</topic><topic>Alleles</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Endophenotypes - analysis</topic><topic>Endophenotypes - metabolism</topic><topic>Epigenesis, Genetic</topic><topic>Genetic aspects</topic><topic>Genetic Association Studies</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Human Genetics</topic><topic>Human Genetics • Review</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - cerebrospinal fluid</topic><topic>Impulsive Behavior - genetics</topic><topic>Impulsive Behavior - psychology</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Neurophysiology</topic><topic>Plant Genetics and Genomics</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins - metabolism</topic><topic>Suicidal behavior</topic><topic>Suicide</topic><topic>Suicide - psychology</topic><topic>Tryptophan Hydroxylase - genetics</topic><topic>Tryptophan Hydroxylase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chistiakov, Dimitry A.</creatorcontrib><creatorcontrib>Kekelidze, Zurab I.</creatorcontrib><creatorcontrib>Chekhonin, Vladimir P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of applied genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chistiakov, Dimitry A.</au><au>Kekelidze, Zurab I.</au><au>Chekhonin, Vladimir P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endophenotypes as a measure of suicidality</atitle><jtitle>Journal of applied genetics</jtitle><stitle>J Appl Genetics</stitle><addtitle>J Appl Genet</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>53</volume><issue>4</issue><spage>389</spage><epage>413</epage><pages>389-413</pages><issn>1234-1983</issn><eissn>2190-3883</eissn><abstract>Suicide is thought to result from the harmful interaction of multiple factors that have social, environmental, neurobiological, and genetic backgrounds. 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| issn | 1234-1983 2190-3883 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alcoholism Alleles Animal Genetics and Genomics Biomedical and Life Sciences Brain - metabolism Brain - pathology Depressive Disorder, Major - diagnosis Endophenotypes - analysis Endophenotypes - metabolism Epigenesis, Genetic Genetic aspects Genetic Association Studies Genetic polymorphisms Genetic Predisposition to Disease Human Genetics Human Genetics • Review Humans Hydroxyindoleacetic Acid - cerebrospinal fluid Impulsive Behavior - genetics Impulsive Behavior - psychology Life Sciences Microbial Genetics and Genomics Neurophysiology Plant Genetics and Genomics Polymorphism, Genetic Risk Factors Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Suicidal behavior Suicide Suicide - psychology Tryptophan Hydroxylase - genetics Tryptophan Hydroxylase - metabolism |
| title | Endophenotypes as a measure of suicidality |
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