Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the β‐catenin/ZEB1 axis

Colorectal cancer (CRC) is a recurring cancer that is often resistant to conventional therapies and therefore requires the development of molecular‐based therapeutic approaches. Dopamine receptor D2 (DRD2) is associated with the growth of many types of tumors, but its oncogenic role in CRC is unclea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2021-09, Vol.112 (9), p.3732-3743
Hauptverfasser:	Lee, Hyunjung, Shim, Sehwan, Kong, Joon Seog, Kim, Min‐Jung, Park, Sunhoo, Lee, Seung‐Sook, Kim, Areumnuri
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals beta Catenin - metabolism Cancer Care and treatment Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Development and progression Disease Progression Dopamine Antagonists - pharmacology Dopamine receptors DRD2 Female HCT116 Cells Health aspects HT29 Cells Humans Life Sciences & Biomedicine Male metastasis Mice Mice, Inbred BALB C Mice, Nude Middle Aged Oncology Original Phenols pimozide Pimozide - pharmacology Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism RNA Interference Science & Technology Signal Transduction Survival Rate Transfection Tumor Burden - drug effects Tumor Burden - genetics Up-Regulation Xenograft Model Antitumor Assays ZEB1 Zinc Finger E-box-Binding Homeobox 1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!