Contribution of Kazal-Like Domains of the Serine Protease Inhibitor-1 from Toxoplasma gondii in Asthma Therapeutic Vaccination Effectiveness

Abstract Background: We have previously showed rTgPI-1 tolerogenic adjuvant properties in asthma treatment, turning it a promising candidate for allergen-specific immunotherapy. This therapy is an alternative treatment to control asthma that still presents several concerns related to its formulation...

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Veröffentlicht in:	International archives of allergy and immunology 2022-05, Vol.183 (5), p.471-478
Hauptverfasser:	Soto, Ariadna, Perrone Sibilia, Matías, Sánchez, Vanesa Roxana, Arcón, Nadia, Martin, Valentina, Fenoy, Ignacio Martín, Goldman, Alejandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Asthma Asthma - pathology Asthma - therapy Bronchoalveolar Lavage Fluid Care and treatment Disease Models, Animal Experimental Allergy – Brief Report Health aspects Immunological research Immunotherapy Leukocyte Elastase Lung - pathology Methods Mice Mice, Inbred BALB C Ovalbumin Physiological aspects Protease inhibitors Recombinant proteins Serine Proteinase Inhibitors Toxoplasma Toxoplasma - genetics Trypsin Vaccination Vaccines
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