Volume of Crescents Affects Prognosis of IgA Nephropathy in Patients without Obvious Chronic Renal Pathology
Introduction: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in the kidney tissue predicted a worse renal outcome. However, the effect of C1 lesion (crescents in
Gespeichert in:
| Veröffentlicht in: | American journal of nephrology 2021-08, Vol.52 (6), p.507-518 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 518 |
|---|---|
| container_issue | 6 |
| container_start_page | 507 |
| container_title | American journal of nephrology |
| container_volume | 52 |
| creator | Lin, Zaoqiang Liu, Lichang Zhang, Rongling Lin, Xuefei Lu, Fuhua Bao, Kun Wang, Lixin Lin, Qizhan Mai, Jianling Cao, Yanfei Yang, Haifeng Liu, Xusheng Zou, Chuan |
| description | Introduction: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in the kidney tissue predicted a worse renal outcome. However, the effect of C1 lesion (crescents in |
| doi_str_mv | 10.1159/000516187 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_karge</sourceid><recordid>TN_cdi_gale_infotracmisc_A709901336</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A709901336</galeid><sourcerecordid>A709901336</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-d5c6614c61a6969e6e3ff831e13fcc0af381f27114f42562d034c3e2c5f5b0713</originalsourceid><addsrcrecordid>eNpt0d2L1DAQAPAgire3-uC7SOFA9KFnJmn68VgWP06Ou0PU15JNJ22029Qk9dj_3qw9Fw-OhAwkvwmZDCEvgJ4DiOodpVRADmXxiKwgY5BWeUEfkxVlgqYlrcQJOfX-B6XASlo8JSc8gziBrsjw3Q7zDhOrk41Dr3AMPqm1RhXjjbPdaL3xh-OLrk6ucOqdnWTo94kZkxsZzN-EWxN6O4fkevvb2Nknm6hGo5IvOMrhwHo72G7_jDzRcvD4_C6uybcP779uPqWX1x8vNvVlqjLOQtoKleeQqRxkXuUV5si1LjkgcK0UlZqXoFkBkOmMiZy1lGeKI1NCiy0tgK_Jm-XeydlfM_rQ7EwsbRjkiPF5DRMZ46Ks4romZwvt5ICNGbUNTqoDb-qCVhUFzvOozh9QcbS4M8qOqE3cv5fw-r-EHuUQeh9_Ohg7-vvw7QKVs9471M3kzE66fQO0OTS3OTY32ld3Zc3bHbZH-a-bEbxcwE_pOnRHcMw_e_C4_ny1iGZqNf8DOomxBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2542358942</pqid></control><display><type>article</type><title>Volume of Crescents Affects Prognosis of IgA Nephropathy in Patients without Obvious Chronic Renal Pathology</title><source>MEDLINE</source><source>Karger Journals</source><creator>Lin, Zaoqiang ; Liu, Lichang ; Zhang, Rongling ; Lin, Xuefei ; Lu, Fuhua ; Bao, Kun ; Wang, Lixin ; Lin, Qizhan ; Mai, Jianling ; Cao, Yanfei ; Yang, Haifeng ; Liu, Xusheng ; Zou, Chuan</creator><creatorcontrib>Lin, Zaoqiang ; Liu, Lichang ; Zhang, Rongling ; Lin, Xuefei ; Lu, Fuhua ; Bao, Kun ; Wang, Lixin ; Lin, Qizhan ; Mai, Jianling ; Cao, Yanfei ; Yang, Haifeng ; Liu, Xusheng ; Zou, Chuan</creatorcontrib><description>Introduction: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in the kidney tissue predicted a worse renal outcome. However, the effect of C1 lesion (crescents in <1/4th of all glomeruli) and their volume on the prognosis of IgAN is still unclear. We explored the association of C1 lesion with the renal prognosis in IgAN patients without obvious chronic renal lesions (glomerulosclerosis <25%, T score <2). Methods: We investigated 305 biopsy-proven IgAN patients without obvious chronic renal lesions. Clinicopathologic features and treatment modalities were recorded. The patients were divided into several groups according to the presence or absence of a global crescent: no crescent (NC) group, only segmental crescent (SC) group, and global crescent (GC) group. The outcome was the survival from a combined event defined by a ≥15% decline in the estimated glomerular filtration rate (eGFR) after 1 year or ≥30% decline in the eGFR after 2 years. Results: Among all patients, 75.7% were in the NC group, 14.8% were in the SC group, and 9.5% were in the GC group. Compared with the NC group, patients in the SC group and the GC group had more urine protein, lower eGFR, and presented with more severe pathological change. During a median follow-up of 34.8 (26.16–57.95) months, the combined event occurred in 34 individuals (11.1%). In a multivariate model, the GC group (HR = 2.756, 95% CI = 1.068–7.109) was associated with an increased risk of the combined event. Conclusions: In IgAN patients without obvious chronic renal lesions, the GC group had more severe clinical and pathological manifestations than in the NC group. GC is an independent risk factor for the progression of IgAN renal function.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000516187</identifier><identifier>PMID: 34134110</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Care and treatment ; Causes of ; Diagnosis ; Disease Progression ; Female ; Glomerular Filtration Rate ; Glomerulonephritis, IGA - complications ; Glomerulonephritis, IGA - pathology ; Glomerulonephritis, IGA - physiopathology ; Health aspects ; Humans ; IgA glomerulonephritis ; Immunoglobulin A ; Kaplan-Meier Estimate ; Kidney diseases ; Kidney Glomerulus - pathology ; Male ; Measurement ; Novel Research Findings ; Prognosis ; Proportional Hazards Models ; Proteinuria - etiology ; Retrospective Studies ; Risk factors ; Survival Rate</subject><ispartof>American journal of nephrology, 2021-08, Vol.52 (6), p.507-518</ispartof><rights>2021 S. Karger AG, Basel</rights><rights>2021 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-d5c6614c61a6969e6e3ff831e13fcc0af381f27114f42562d034c3e2c5f5b0713</citedby><cites>FETCH-LOGICAL-c432t-d5c6614c61a6969e6e3ff831e13fcc0af381f27114f42562d034c3e2c5f5b0713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34134110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Zaoqiang</creatorcontrib><creatorcontrib>Liu, Lichang</creatorcontrib><creatorcontrib>Zhang, Rongling</creatorcontrib><creatorcontrib>Lin, Xuefei</creatorcontrib><creatorcontrib>Lu, Fuhua</creatorcontrib><creatorcontrib>Bao, Kun</creatorcontrib><creatorcontrib>Wang, Lixin</creatorcontrib><creatorcontrib>Lin, Qizhan</creatorcontrib><creatorcontrib>Mai, Jianling</creatorcontrib><creatorcontrib>Cao, Yanfei</creatorcontrib><creatorcontrib>Yang, Haifeng</creatorcontrib><creatorcontrib>Liu, Xusheng</creatorcontrib><creatorcontrib>Zou, Chuan</creatorcontrib><title>Volume of Crescents Affects Prognosis of IgA Nephropathy in Patients without Obvious Chronic Renal Pathology</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Introduction: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in the kidney tissue predicted a worse renal outcome. However, the effect of C1 lesion (crescents in <1/4th of all glomeruli) and their volume on the prognosis of IgAN is still unclear. We explored the association of C1 lesion with the renal prognosis in IgAN patients without obvious chronic renal lesions (glomerulosclerosis <25%, T score <2). Methods: We investigated 305 biopsy-proven IgAN patients without obvious chronic renal lesions. Clinicopathologic features and treatment modalities were recorded. The patients were divided into several groups according to the presence or absence of a global crescent: no crescent (NC) group, only segmental crescent (SC) group, and global crescent (GC) group. The outcome was the survival from a combined event defined by a ≥15% decline in the estimated glomerular filtration rate (eGFR) after 1 year or ≥30% decline in the eGFR after 2 years. Results: Among all patients, 75.7% were in the NC group, 14.8% were in the SC group, and 9.5% were in the GC group. Compared with the NC group, patients in the SC group and the GC group had more urine protein, lower eGFR, and presented with more severe pathological change. During a median follow-up of 34.8 (26.16–57.95) months, the combined event occurred in 34 individuals (11.1%). In a multivariate model, the GC group (HR = 2.756, 95% CI = 1.068–7.109) was associated with an increased risk of the combined event. Conclusions: In IgAN patients without obvious chronic renal lesions, the GC group had more severe clinical and pathological manifestations than in the NC group. GC is an independent risk factor for the progression of IgAN renal function.</description><subject>Adult</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Diagnosis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Glomerulonephritis, IGA - complications</subject><subject>Glomerulonephritis, IGA - pathology</subject><subject>Glomerulonephritis, IGA - physiopathology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>IgA glomerulonephritis</subject><subject>Immunoglobulin A</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney diseases</subject><subject>Kidney Glomerulus - pathology</subject><subject>Male</subject><subject>Measurement</subject><subject>Novel Research Findings</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Proteinuria - etiology</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Survival Rate</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0d2L1DAQAPAgire3-uC7SOFA9KFnJmn68VgWP06Ou0PU15JNJ22029Qk9dj_3qw9Fw-OhAwkvwmZDCEvgJ4DiOodpVRADmXxiKwgY5BWeUEfkxVlgqYlrcQJOfX-B6XASlo8JSc8gziBrsjw3Q7zDhOrk41Dr3AMPqm1RhXjjbPdaL3xh-OLrk6ucOqdnWTo94kZkxsZzN-EWxN6O4fkevvb2Nknm6hGo5IvOMrhwHo72G7_jDzRcvD4_C6uybcP779uPqWX1x8vNvVlqjLOQtoKleeQqRxkXuUV5si1LjkgcK0UlZqXoFkBkOmMiZy1lGeKI1NCiy0tgK_Jm-XeydlfM_rQ7EwsbRjkiPF5DRMZ46Ks4romZwvt5ICNGbUNTqoDb-qCVhUFzvOozh9QcbS4M8qOqE3cv5fw-r-EHuUQeh9_Ohg7-vvw7QKVs9471M3kzE66fQO0OTS3OTY32ld3Zc3bHbZH-a-bEbxcwE_pOnRHcMw_e_C4_ny1iGZqNf8DOomxBw</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Lin, Zaoqiang</creator><creator>Liu, Lichang</creator><creator>Zhang, Rongling</creator><creator>Lin, Xuefei</creator><creator>Lu, Fuhua</creator><creator>Bao, Kun</creator><creator>Wang, Lixin</creator><creator>Lin, Qizhan</creator><creator>Mai, Jianling</creator><creator>Cao, Yanfei</creator><creator>Yang, Haifeng</creator><creator>Liu, Xusheng</creator><creator>Zou, Chuan</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Volume of Crescents Affects Prognosis of IgA Nephropathy in Patients without Obvious Chronic Renal Pathology</title><author>Lin, Zaoqiang ; Liu, Lichang ; Zhang, Rongling ; Lin, Xuefei ; Lu, Fuhua ; Bao, Kun ; Wang, Lixin ; Lin, Qizhan ; Mai, Jianling ; Cao, Yanfei ; Yang, Haifeng ; Liu, Xusheng ; Zou, Chuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-d5c6614c61a6969e6e3ff831e13fcc0af381f27114f42562d034c3e2c5f5b0713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Diagnosis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Glomerulonephritis, IGA - complications</topic><topic>Glomerulonephritis, IGA - pathology</topic><topic>Glomerulonephritis, IGA - physiopathology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>IgA glomerulonephritis</topic><topic>Immunoglobulin A</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney diseases</topic><topic>Kidney Glomerulus - pathology</topic><topic>Male</topic><topic>Measurement</topic><topic>Novel Research Findings</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Proteinuria - etiology</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Zaoqiang</creatorcontrib><creatorcontrib>Liu, Lichang</creatorcontrib><creatorcontrib>Zhang, Rongling</creatorcontrib><creatorcontrib>Lin, Xuefei</creatorcontrib><creatorcontrib>Lu, Fuhua</creatorcontrib><creatorcontrib>Bao, Kun</creatorcontrib><creatorcontrib>Wang, Lixin</creatorcontrib><creatorcontrib>Lin, Qizhan</creatorcontrib><creatorcontrib>Mai, Jianling</creatorcontrib><creatorcontrib>Cao, Yanfei</creatorcontrib><creatorcontrib>Yang, Haifeng</creatorcontrib><creatorcontrib>Liu, Xusheng</creatorcontrib><creatorcontrib>Zou, Chuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Zaoqiang</au><au>Liu, Lichang</au><au>Zhang, Rongling</au><au>Lin, Xuefei</au><au>Lu, Fuhua</au><au>Bao, Kun</au><au>Wang, Lixin</au><au>Lin, Qizhan</au><au>Mai, Jianling</au><au>Cao, Yanfei</au><au>Yang, Haifeng</au><au>Liu, Xusheng</au><au>Zou, Chuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volume of Crescents Affects Prognosis of IgA Nephropathy in Patients without Obvious Chronic Renal Pathology</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>52</volume><issue>6</issue><spage>507</spage><epage>518</epage><pages>507-518</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><abstract>Introduction: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in the kidney tissue predicted a worse renal outcome. However, the effect of C1 lesion (crescents in <1/4th of all glomeruli) and their volume on the prognosis of IgAN is still unclear. We explored the association of C1 lesion with the renal prognosis in IgAN patients without obvious chronic renal lesions (glomerulosclerosis <25%, T score <2). Methods: We investigated 305 biopsy-proven IgAN patients without obvious chronic renal lesions. Clinicopathologic features and treatment modalities were recorded. The patients were divided into several groups according to the presence or absence of a global crescent: no crescent (NC) group, only segmental crescent (SC) group, and global crescent (GC) group. The outcome was the survival from a combined event defined by a ≥15% decline in the estimated glomerular filtration rate (eGFR) after 1 year or ≥30% decline in the eGFR after 2 years. Results: Among all patients, 75.7% were in the NC group, 14.8% were in the SC group, and 9.5% were in the GC group. Compared with the NC group, patients in the SC group and the GC group had more urine protein, lower eGFR, and presented with more severe pathological change. During a median follow-up of 34.8 (26.16–57.95) months, the combined event occurred in 34 individuals (11.1%). In a multivariate model, the GC group (HR = 2.756, 95% CI = 1.068–7.109) was associated with an increased risk of the combined event. Conclusions: In IgAN patients without obvious chronic renal lesions, the GC group had more severe clinical and pathological manifestations than in the NC group. GC is an independent risk factor for the progression of IgAN renal function.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>34134110</pmid><doi>10.1159/000516187</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-8095 |
| ispartof | American journal of nephrology, 2021-08, Vol.52 (6), p.507-518 |
| issn | 0250-8095 1421-9670 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A709901336 |
| source | MEDLINE; Karger Journals |
| subjects | Adult Care and treatment Causes of Diagnosis Disease Progression Female Glomerular Filtration Rate Glomerulonephritis, IGA - complications Glomerulonephritis, IGA - pathology Glomerulonephritis, IGA - physiopathology Health aspects Humans IgA glomerulonephritis Immunoglobulin A Kaplan-Meier Estimate Kidney diseases Kidney Glomerulus - pathology Male Measurement Novel Research Findings Prognosis Proportional Hazards Models Proteinuria - etiology Retrospective Studies Risk factors Survival Rate |
| title | Volume of Crescents Affects Prognosis of IgA Nephropathy in Patients without Obvious Chronic Renal Pathology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T00%3A28%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Volume%20of%20Crescents%20Affects%20Prognosis%20of%20IgA%20Nephropathy%20in%20Patients%20without%20Obvious%20Chronic%20Renal%20Pathology&rft.jtitle=American%20journal%20of%20nephrology&rft.au=Lin,%20Zaoqiang&rft.date=2021-08-01&rft.volume=52&rft.issue=6&rft.spage=507&rft.epage=518&rft.pages=507-518&rft.issn=0250-8095&rft.eissn=1421-9670&rft_id=info:doi/10.1159/000516187&rft_dat=%3Cgale_karge%3EA709901336%3C/gale_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2542358942&rft_id=info:pmid/34134110&rft_galeid=A709901336&rfr_iscdi=true |