Trimethylamine N-oxide Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults
Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. Objective:...
Gespeichert in:
| Veröffentlicht in: | Current developments in nutrition 2021-01, Vol.5 (1), p.1 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Current developments in nutrition |
| container_volume | 5 |
| creator | Andraos, Stephanie Jones, Beatrix Lange, Katherine Clifford, Susan A Thorstensen, Eric B Kerr, Jessica A Wake, Melissa Saffery, Richard Burgner, David P O'Sullivan, Justin M |
| description | Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. Objective: We aimed to investigate the associations between plasma TMAO concentrations and its precursors [carnitine, choline, betaine, and dimethylglycine (DMG)] with metabolic syndrome (MetS) scores, preclinical cardiovascular phenotypes, and inflammatory biomarkers (i.e. high-sensitivity C-reactive protein and serum glycoprotein acetyls) in a population-derived cohort of children and their parents. Methods: The concentrations of TMAO and its precursors were quantified using UHPLC coupled with tandem MS (UHPLC/MS-MS) in 1166 children (mean age 11 y [+ or -] 0.5 y, 51% female) and 1324 adults (44 y [+ or -] 5.1 y, 87% female) participating in The Growing Up in Australia's Child Health CheckPoint Study. We developed multivariable fractional polynomial models to analyze associations between TMAO, its precursors, MetS (adjusted for sex and age), and cardiovascular phenotypes (adjusted for sex, age, BMI, household income, and the urinary albumin to creatinine ratio). Pearson's correlations were computed to identify associations between TMAO, its precursors, and inflammatory biomarkers. Results: The concentrations of TMAO precursors, but not TMAO itself, were associated with MetS, cardiovascular phenotypes, and inflammatory biomarkers in children and adults. Conclusions: TMAO precursors, but not TMAO itself, were associated with adverse cardiometabolic and inflammatory phenotypes in children and adults. TMAO precursor concentrations may better reflect cardiovascular health and inflammatory status within the wider population. Replication in other population settings and mechanistic studies are warranted. Curr Dev Nutr 2021;5:nzaa179. Keywords: TMAO, children, adults, Growing Up in Australia, epidemiology, cardiovascular preclinical phenotypes |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A709279190</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A709279190</galeid><sourcerecordid>A709279190</sourcerecordid><originalsourceid>FETCH-LOGICAL-g670-4ca844607ac91e09f16e3a4964c314fbe23b6acec3ab771c1310ae7213d4f9e53</originalsourceid><addsrcrecordid>eNptjE1LxDAYhIsouKz7HwKeK0mTbcyxFD8W1o9D78vb5M022iaSRNz99xb1sAeZwwzDM3NWLCoh12WlFDs_yZfFKqU3SilTStVULYpDF92EeTiOMDmP5LkMB2eQbBLxIZMmpaAdZDTky-WBtBCNC_MA-jA6TV4HnLHjByYC3pCNt_PPBDnEI3mC-I4xEedJO7jRRPQ_UGM-x5yuigsLY8LVny-L7v6uax_L7cvDpm225b6WtBQaboWoqQStGFJlWY0chKqF5kzYHive16BRc-ilZJpxRgFlxbgRVuGaL4vr39s9jLhz3oYcQU8u6V0jqaqkYorO1M0_1CyDk9PBo3VzfzL4BgpLawY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Trimethylamine N-oxide Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults</title><source>DOAJ Directory of Open Access Journals</source><source>Oxford Journals Open Access Collection</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Andraos, Stephanie ; Jones, Beatrix ; Lange, Katherine ; Clifford, Susan A ; Thorstensen, Eric B ; Kerr, Jessica A ; Wake, Melissa ; Saffery, Richard ; Burgner, David P ; O'Sullivan, Justin M</creator><creatorcontrib>Andraos, Stephanie ; Jones, Beatrix ; Lange, Katherine ; Clifford, Susan A ; Thorstensen, Eric B ; Kerr, Jessica A ; Wake, Melissa ; Saffery, Richard ; Burgner, David P ; O'Sullivan, Justin M</creatorcontrib><description>Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. Objective: We aimed to investigate the associations between plasma TMAO concentrations and its precursors [carnitine, choline, betaine, and dimethylglycine (DMG)] with metabolic syndrome (MetS) scores, preclinical cardiovascular phenotypes, and inflammatory biomarkers (i.e. high-sensitivity C-reactive protein and serum glycoprotein acetyls) in a population-derived cohort of children and their parents. Methods: The concentrations of TMAO and its precursors were quantified using UHPLC coupled with tandem MS (UHPLC/MS-MS) in 1166 children (mean age 11 y [+ or -] 0.5 y, 51% female) and 1324 adults (44 y [+ or -] 5.1 y, 87% female) participating in The Growing Up in Australia's Child Health CheckPoint Study. We developed multivariable fractional polynomial models to analyze associations between TMAO, its precursors, MetS (adjusted for sex and age), and cardiovascular phenotypes (adjusted for sex, age, BMI, household income, and the urinary albumin to creatinine ratio). Pearson's correlations were computed to identify associations between TMAO, its precursors, and inflammatory biomarkers. Results: The concentrations of TMAO precursors, but not TMAO itself, were associated with MetS, cardiovascular phenotypes, and inflammatory biomarkers in children and adults. Conclusions: TMAO precursors, but not TMAO itself, were associated with adverse cardiometabolic and inflammatory phenotypes in children and adults. TMAO precursor concentrations may better reflect cardiovascular health and inflammatory status within the wider population. Replication in other population settings and mechanistic studies are warranted. Curr Dev Nutr 2021;5:nzaa179. Keywords: TMAO, children, adults, Growing Up in Australia, epidemiology, cardiovascular preclinical phenotypes</description><identifier>ISSN: 2475-2991</identifier><identifier>EISSN: 2475-2991</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Biological markers ; Cardiovascular diseases ; Diagnosis ; Health aspects ; Metabolic diseases ; Metabolites</subject><ispartof>Current developments in nutrition, 2021-01, Vol.5 (1), p.1</ispartof><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Andraos, Stephanie</creatorcontrib><creatorcontrib>Jones, Beatrix</creatorcontrib><creatorcontrib>Lange, Katherine</creatorcontrib><creatorcontrib>Clifford, Susan A</creatorcontrib><creatorcontrib>Thorstensen, Eric B</creatorcontrib><creatorcontrib>Kerr, Jessica A</creatorcontrib><creatorcontrib>Wake, Melissa</creatorcontrib><creatorcontrib>Saffery, Richard</creatorcontrib><creatorcontrib>Burgner, David P</creatorcontrib><creatorcontrib>O'Sullivan, Justin M</creatorcontrib><title>Trimethylamine N-oxide Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults</title><title>Current developments in nutrition</title><description>Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. Objective: We aimed to investigate the associations between plasma TMAO concentrations and its precursors [carnitine, choline, betaine, and dimethylglycine (DMG)] with metabolic syndrome (MetS) scores, preclinical cardiovascular phenotypes, and inflammatory biomarkers (i.e. high-sensitivity C-reactive protein and serum glycoprotein acetyls) in a population-derived cohort of children and their parents. Methods: The concentrations of TMAO and its precursors were quantified using UHPLC coupled with tandem MS (UHPLC/MS-MS) in 1166 children (mean age 11 y [+ or -] 0.5 y, 51% female) and 1324 adults (44 y [+ or -] 5.1 y, 87% female) participating in The Growing Up in Australia's Child Health CheckPoint Study. We developed multivariable fractional polynomial models to analyze associations between TMAO, its precursors, MetS (adjusted for sex and age), and cardiovascular phenotypes (adjusted for sex, age, BMI, household income, and the urinary albumin to creatinine ratio). Pearson's correlations were computed to identify associations between TMAO, its precursors, and inflammatory biomarkers. Results: The concentrations of TMAO precursors, but not TMAO itself, were associated with MetS, cardiovascular phenotypes, and inflammatory biomarkers in children and adults. Conclusions: TMAO precursors, but not TMAO itself, were associated with adverse cardiometabolic and inflammatory phenotypes in children and adults. TMAO precursor concentrations may better reflect cardiovascular health and inflammatory status within the wider population. Replication in other population settings and mechanistic studies are warranted. Curr Dev Nutr 2021;5:nzaa179. Keywords: TMAO, children, adults, Growing Up in Australia, epidemiology, cardiovascular preclinical phenotypes</description><subject>Biological markers</subject><subject>Cardiovascular diseases</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Metabolic diseases</subject><subject>Metabolites</subject><issn>2475-2991</issn><issn>2475-2991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjE1LxDAYhIsouKz7HwKeK0mTbcyxFD8W1o9D78vb5M022iaSRNz99xb1sAeZwwzDM3NWLCoh12WlFDs_yZfFKqU3SilTStVULYpDF92EeTiOMDmP5LkMB2eQbBLxIZMmpaAdZDTky-WBtBCNC_MA-jA6TV4HnLHjByYC3pCNt_PPBDnEI3mC-I4xEedJO7jRRPQ_UGM-x5yuigsLY8LVny-L7v6uax_L7cvDpm225b6WtBQaboWoqQStGFJlWY0chKqF5kzYHive16BRc-ilZJpxRgFlxbgRVuGaL4vr39s9jLhz3oYcQU8u6V0jqaqkYorO1M0_1CyDk9PBo3VzfzL4BgpLawY</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Andraos, Stephanie</creator><creator>Jones, Beatrix</creator><creator>Lange, Katherine</creator><creator>Clifford, Susan A</creator><creator>Thorstensen, Eric B</creator><creator>Kerr, Jessica A</creator><creator>Wake, Melissa</creator><creator>Saffery, Richard</creator><creator>Burgner, David P</creator><creator>O'Sullivan, Justin M</creator><general>Oxford University Press</general><scope/></search><sort><creationdate>20210101</creationdate><title>Trimethylamine N-oxide Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults</title><author>Andraos, Stephanie ; Jones, Beatrix ; Lange, Katherine ; Clifford, Susan A ; Thorstensen, Eric B ; Kerr, Jessica A ; Wake, Melissa ; Saffery, Richard ; Burgner, David P ; O'Sullivan, Justin M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g670-4ca844607ac91e09f16e3a4964c314fbe23b6acec3ab771c1310ae7213d4f9e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biological markers</topic><topic>Cardiovascular diseases</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>Metabolic diseases</topic><topic>Metabolites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andraos, Stephanie</creatorcontrib><creatorcontrib>Jones, Beatrix</creatorcontrib><creatorcontrib>Lange, Katherine</creatorcontrib><creatorcontrib>Clifford, Susan A</creatorcontrib><creatorcontrib>Thorstensen, Eric B</creatorcontrib><creatorcontrib>Kerr, Jessica A</creatorcontrib><creatorcontrib>Wake, Melissa</creatorcontrib><creatorcontrib>Saffery, Richard</creatorcontrib><creatorcontrib>Burgner, David P</creatorcontrib><creatorcontrib>O'Sullivan, Justin M</creatorcontrib><jtitle>Current developments in nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andraos, Stephanie</au><au>Jones, Beatrix</au><au>Lange, Katherine</au><au>Clifford, Susan A</au><au>Thorstensen, Eric B</au><au>Kerr, Jessica A</au><au>Wake, Melissa</au><au>Saffery, Richard</au><au>Burgner, David P</au><au>O'Sullivan, Justin M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trimethylamine N-oxide Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults</atitle><jtitle>Current developments in nutrition</jtitle><date>2021-01-01</date><risdate>2021</risdate><volume>5</volume><issue>1</issue><spage>1</spage><pages>1-</pages><issn>2475-2991</issn><eissn>2475-2991</eissn><abstract>Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. Objective: We aimed to investigate the associations between plasma TMAO concentrations and its precursors [carnitine, choline, betaine, and dimethylglycine (DMG)] with metabolic syndrome (MetS) scores, preclinical cardiovascular phenotypes, and inflammatory biomarkers (i.e. high-sensitivity C-reactive protein and serum glycoprotein acetyls) in a population-derived cohort of children and their parents. Methods: The concentrations of TMAO and its precursors were quantified using UHPLC coupled with tandem MS (UHPLC/MS-MS) in 1166 children (mean age 11 y [+ or -] 0.5 y, 51% female) and 1324 adults (44 y [+ or -] 5.1 y, 87% female) participating in The Growing Up in Australia's Child Health CheckPoint Study. We developed multivariable fractional polynomial models to analyze associations between TMAO, its precursors, MetS (adjusted for sex and age), and cardiovascular phenotypes (adjusted for sex, age, BMI, household income, and the urinary albumin to creatinine ratio). Pearson's correlations were computed to identify associations between TMAO, its precursors, and inflammatory biomarkers. Results: The concentrations of TMAO precursors, but not TMAO itself, were associated with MetS, cardiovascular phenotypes, and inflammatory biomarkers in children and adults. Conclusions: TMAO precursors, but not TMAO itself, were associated with adverse cardiometabolic and inflammatory phenotypes in children and adults. TMAO precursor concentrations may better reflect cardiovascular health and inflammatory status within the wider population. Replication in other population settings and mechanistic studies are warranted. Curr Dev Nutr 2021;5:nzaa179. Keywords: TMAO, children, adults, Growing Up in Australia, epidemiology, cardiovascular preclinical phenotypes</abstract><pub>Oxford University Press</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2475-2991 |
| ispartof | Current developments in nutrition, 2021-01, Vol.5 (1), p.1 |
| issn | 2475-2991 2475-2991 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A709279190 |
| source | DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biological markers Cardiovascular diseases Diagnosis Health aspects Metabolic diseases Metabolites |
| title | Trimethylamine N-oxide Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T22%3A22%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trimethylamine%20N-oxide%20Is%20not%20Associated%20with%20Cardiometabolic%20Phenotypes%20and%20Inflammatory%20Markers%20in%20Children%20and%20Adults&rft.jtitle=Current%20developments%20in%20nutrition&rft.au=Andraos,%20Stephanie&rft.date=2021-01-01&rft.volume=5&rft.issue=1&rft.spage=1&rft.pages=1-&rft.issn=2475-2991&rft.eissn=2475-2991&rft_id=info:doi/&rft_dat=%3Cgale%3EA709279190%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A709279190&rfr_iscdi=true |