Impact of opioids on P2[Y.sub.12] receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation trial
Aims Platelet inhibition induced by [P2Y.sub.12] receptor antagonists in patients with ST-elevation myocardial infarction (STEMI) can be affected by concomitant use of opioids. The aim of this trial was to examine the effect of intravenous (iv) acetaminophen compared with iv fentanyl on [P2Y.sub.12]...
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| Veröffentlicht in: | European heart journal. Cardiovascular pharmacotherapy 2022-01, Vol.8 (1), p.4 |
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| creator | Tavenier, Anne H Hermanides, Renicus S Ottervanger, Jan Paul Tolsma, Rudolf Beurden, Antony van Slingerland, Robbert Jan Horst, Peter G.J. ter A.Gosselink, T. Marcel Jan-Dambrink, Henk E Leeuwen, Maarten A.H. van Roolvink, Vincent Kedhi, Elvin Klungel, Olaf H Belitser, Svetlana V Angiolillo, Dominick J Pustjens, Tobias Rasoul, Saman Gho, Ben Stein, Mera Ruiters, Lex W.J. van 'Hof, Arnoud t |
| description | Aims Platelet inhibition induced by [P2Y.sub.12] receptor antagonists in patients with ST-elevation myocardial infarction (STEMI) can be affected by concomitant use of opioids. The aim of this trial was to examine the effect of intravenous (iv) acetaminophen compared with iv fentanyl on [P2Y.sub.12] receptor inhibition in patients with STEMI. Methods and The Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial randomized 195 STEMI results patients who were scheduled to undergo primary percutaneous coronary intervention (PCI) and were pre-treated with crushed ticagrelor to iv acetaminophen (N = 98) or iv fentanyl (N = 97) in the ambulance. The primary endpoint, consisting of the level of platelet reactivity units (PRU) measured immediately after primary PCI, was not significantly different between the study arms [median PRU 104 (IQR 37-215) vs. 175 (63-228), P= 0.18]. However, systemic levels of ticagrelor were significantly higher in the acetaminophen arm at the start of primary PCI [151 ng/mL (32-509) vs. 60 ng/mL (13-206), P= 0.007], immediately after primary PCI [326 ng/mL (94-791) vs. 115 ng/mL (38-326), P = 0.002], and at 1 h after primary PCI [488 ng/mL (281-974) vs. 372 ng/mL (95-635), P= 0.002]. Acetaminophen resulted in the same extent of pain relief when compared with fentanyl [reduction of 3 points on 10-step-pain scale before primary PCI (IQR 1-5)] in both study arms (P= 0.67) and immediately after PCI [reduction of 5 points (3-7); P= 0.96]. Conclusion The iv acetaminophen in comparison with iv fentanyl was not associated with significantly lower platelet reactivity in STEMI patients but resulted in significantly higher ticagrelor plasma levels and was effective in pain relief. Keywords ST-elevation myocardial infarction * Acetaminophen * Fentanyl * Acetaminophen * Primary coronary intervention * Ticagrelor |
| doi_str_mv | 10.1093/ehjcvp/pvaa095 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A701923725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A701923725</galeid><sourcerecordid>A701923725</sourcerecordid><originalsourceid>FETCH-LOGICAL-g675-84d75a5ffcb91ec1682f92a06834e5fb58dfaa89474559aaad6acfe07a77e81b3</originalsourceid><addsrcrecordid>eNptUE1Lw0AQzUHBUnv1vOA57eZjs4m3UqoWqhXMRUTKZDPbbEmyYbNt8df6V1zaIh7KHIZ5783M43neXUDHAc2iCVZbse8m3R6AZuzKG4SUMT9JI37jjfp-SykNkjQJ02jg_SyaDoQlWhLdKa3KnuiWvIWfH-N-V4yD8IsYFNhZbYhqK1Uoq5xAtaQDq7C1PTkoW5H33Mca93Bkm28twJQKaieUYMQRPVSagEHSGfStQbBYnnaF2fWVG6wSsDFYa_NAVmcz8Fr-8fkfTxYtebn4ZL6HendyYY3jbr1rCXWPo3MfevnjPJ89-8vV02I2XfqbhDM_jUvOgEkpiixA4dIJZRYCdZnFyGTB0lICpFnMY8YyACgTEBIpB84xDYpo6N2fzm6gxrXzo60B0aherKecBlkY8ZA51fiCylWJjRK6Rakc_m_hF4WxloU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Impact of opioids on P2[Y.sub.12] receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation trial</title><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Tavenier, Anne H ; Hermanides, Renicus S ; Ottervanger, Jan Paul ; Tolsma, Rudolf ; Beurden, Antony van ; Slingerland, Robbert Jan ; Horst, Peter G.J. ter ; A.Gosselink, T. Marcel ; Jan-Dambrink, Henk E ; Leeuwen, Maarten A.H. van ; Roolvink, Vincent ; Kedhi, Elvin ; Klungel, Olaf H ; Belitser, Svetlana V ; Angiolillo, Dominick J ; Pustjens, Tobias ; Rasoul, Saman ; Gho, Ben ; Stein, Mera ; Ruiters, Lex ; W.J. van 'Hof, Arnoud t</creator><creatorcontrib>Tavenier, Anne H ; Hermanides, Renicus S ; Ottervanger, Jan Paul ; Tolsma, Rudolf ; Beurden, Antony van ; Slingerland, Robbert Jan ; Horst, Peter G.J. ter ; A.Gosselink, T. Marcel ; Jan-Dambrink, Henk E ; Leeuwen, Maarten A.H. van ; Roolvink, Vincent ; Kedhi, Elvin ; Klungel, Olaf H ; Belitser, Svetlana V ; Angiolillo, Dominick J ; Pustjens, Tobias ; Rasoul, Saman ; Gho, Ben ; Stein, Mera ; Ruiters, Lex ; W.J. van 'Hof, Arnoud t</creatorcontrib><description>Aims Platelet inhibition induced by [P2Y.sub.12] receptor antagonists in patients with ST-elevation myocardial infarction (STEMI) can be affected by concomitant use of opioids. The aim of this trial was to examine the effect of intravenous (iv) acetaminophen compared with iv fentanyl on [P2Y.sub.12] receptor inhibition in patients with STEMI. Methods and The Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial randomized 195 STEMI results patients who were scheduled to undergo primary percutaneous coronary intervention (PCI) and were pre-treated with crushed ticagrelor to iv acetaminophen (N = 98) or iv fentanyl (N = 97) in the ambulance. The primary endpoint, consisting of the level of platelet reactivity units (PRU) measured immediately after primary PCI, was not significantly different between the study arms [median PRU 104 (IQR 37-215) vs. 175 (63-228), P= 0.18]. However, systemic levels of ticagrelor were significantly higher in the acetaminophen arm at the start of primary PCI [151 ng/mL (32-509) vs. 60 ng/mL (13-206), P= 0.007], immediately after primary PCI [326 ng/mL (94-791) vs. 115 ng/mL (38-326), P = 0.002], and at 1 h after primary PCI [488 ng/mL (281-974) vs. 372 ng/mL (95-635), P= 0.002]. Acetaminophen resulted in the same extent of pain relief when compared with fentanyl [reduction of 3 points on 10-step-pain scale before primary PCI (IQR 1-5)] in both study arms (P= 0.67) and immediately after PCI [reduction of 5 points (3-7); P= 0.96]. Conclusion The iv acetaminophen in comparison with iv fentanyl was not associated with significantly lower platelet reactivity in STEMI patients but resulted in significantly higher ticagrelor plasma levels and was effective in pain relief. Keywords ST-elevation myocardial infarction * Acetaminophen * Fentanyl * Acetaminophen * Primary coronary intervention * Ticagrelor</description><identifier>ISSN: 2055-6837</identifier><identifier>DOI: 10.1093/ehjcvp/pvaa095</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Acetaminophen ; Care and treatment ; Comparative analysis ; Evaluation ; Heart attack ; Opioids ; Pain ; Ticagrelor ; Transluminal angioplasty</subject><ispartof>European heart journal. Cardiovascular pharmacotherapy, 2022-01, Vol.8 (1), p.4</ispartof><rights>COPYRIGHT 2022 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Tavenier, Anne H</creatorcontrib><creatorcontrib>Hermanides, Renicus S</creatorcontrib><creatorcontrib>Ottervanger, Jan Paul</creatorcontrib><creatorcontrib>Tolsma, Rudolf</creatorcontrib><creatorcontrib>Beurden, Antony van</creatorcontrib><creatorcontrib>Slingerland, Robbert Jan</creatorcontrib><creatorcontrib>Horst, Peter G.J. ter</creatorcontrib><creatorcontrib>A.Gosselink, T. Marcel</creatorcontrib><creatorcontrib>Jan-Dambrink, Henk E</creatorcontrib><creatorcontrib>Leeuwen, Maarten A.H. van</creatorcontrib><creatorcontrib>Roolvink, Vincent</creatorcontrib><creatorcontrib>Kedhi, Elvin</creatorcontrib><creatorcontrib>Klungel, Olaf H</creatorcontrib><creatorcontrib>Belitser, Svetlana V</creatorcontrib><creatorcontrib>Angiolillo, Dominick J</creatorcontrib><creatorcontrib>Pustjens, Tobias</creatorcontrib><creatorcontrib>Rasoul, Saman</creatorcontrib><creatorcontrib>Gho, Ben</creatorcontrib><creatorcontrib>Stein, Mera</creatorcontrib><creatorcontrib>Ruiters, Lex</creatorcontrib><creatorcontrib>W.J. van 'Hof, Arnoud t</creatorcontrib><title>Impact of opioids on P2[Y.sub.12] receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation trial</title><title>European heart journal. Cardiovascular pharmacotherapy</title><description>Aims Platelet inhibition induced by [P2Y.sub.12] receptor antagonists in patients with ST-elevation myocardial infarction (STEMI) can be affected by concomitant use of opioids. The aim of this trial was to examine the effect of intravenous (iv) acetaminophen compared with iv fentanyl on [P2Y.sub.12] receptor inhibition in patients with STEMI. Methods and The Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial randomized 195 STEMI results patients who were scheduled to undergo primary percutaneous coronary intervention (PCI) and were pre-treated with crushed ticagrelor to iv acetaminophen (N = 98) or iv fentanyl (N = 97) in the ambulance. The primary endpoint, consisting of the level of platelet reactivity units (PRU) measured immediately after primary PCI, was not significantly different between the study arms [median PRU 104 (IQR 37-215) vs. 175 (63-228), P= 0.18]. However, systemic levels of ticagrelor were significantly higher in the acetaminophen arm at the start of primary PCI [151 ng/mL (32-509) vs. 60 ng/mL (13-206), P= 0.007], immediately after primary PCI [326 ng/mL (94-791) vs. 115 ng/mL (38-326), P = 0.002], and at 1 h after primary PCI [488 ng/mL (281-974) vs. 372 ng/mL (95-635), P= 0.002]. Acetaminophen resulted in the same extent of pain relief when compared with fentanyl [reduction of 3 points on 10-step-pain scale before primary PCI (IQR 1-5)] in both study arms (P= 0.67) and immediately after PCI [reduction of 5 points (3-7); P= 0.96]. Conclusion The iv acetaminophen in comparison with iv fentanyl was not associated with significantly lower platelet reactivity in STEMI patients but resulted in significantly higher ticagrelor plasma levels and was effective in pain relief. Keywords ST-elevation myocardial infarction * Acetaminophen * Fentanyl * Acetaminophen * Primary coronary intervention * Ticagrelor</description><subject>Acetaminophen</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Evaluation</subject><subject>Heart attack</subject><subject>Opioids</subject><subject>Pain</subject><subject>Ticagrelor</subject><subject>Transluminal angioplasty</subject><issn>2055-6837</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptUE1Lw0AQzUHBUnv1vOA57eZjs4m3UqoWqhXMRUTKZDPbbEmyYbNt8df6V1zaIh7KHIZ5783M43neXUDHAc2iCVZbse8m3R6AZuzKG4SUMT9JI37jjfp-SykNkjQJ02jg_SyaDoQlWhLdKa3KnuiWvIWfH-N-V4yD8IsYFNhZbYhqK1Uoq5xAtaQDq7C1PTkoW5H33Mca93Bkm28twJQKaieUYMQRPVSagEHSGfStQbBYnnaF2fWVG6wSsDFYa_NAVmcz8Fr-8fkfTxYtebn4ZL6HendyYY3jbr1rCXWPo3MfevnjPJ89-8vV02I2XfqbhDM_jUvOgEkpiixA4dIJZRYCdZnFyGTB0lICpFnMY8YyACgTEBIpB84xDYpo6N2fzm6gxrXzo60B0aherKecBlkY8ZA51fiCylWJjRK6Rakc_m_hF4WxloU</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Tavenier, Anne H</creator><creator>Hermanides, Renicus S</creator><creator>Ottervanger, Jan Paul</creator><creator>Tolsma, Rudolf</creator><creator>Beurden, Antony van</creator><creator>Slingerland, Robbert Jan</creator><creator>Horst, Peter G.J. ter</creator><creator>A.Gosselink, T. Marcel</creator><creator>Jan-Dambrink, Henk E</creator><creator>Leeuwen, Maarten A.H. van</creator><creator>Roolvink, Vincent</creator><creator>Kedhi, Elvin</creator><creator>Klungel, Olaf H</creator><creator>Belitser, Svetlana V</creator><creator>Angiolillo, Dominick J</creator><creator>Pustjens, Tobias</creator><creator>Rasoul, Saman</creator><creator>Gho, Ben</creator><creator>Stein, Mera</creator><creator>Ruiters, Lex</creator><creator>W.J. van 'Hof, Arnoud t</creator><general>Oxford University Press</general><scope/></search><sort><creationdate>20220101</creationdate><title>Impact of opioids on P2[Y.sub.12] receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation trial</title><author>Tavenier, Anne H ; Hermanides, Renicus S ; Ottervanger, Jan Paul ; Tolsma, Rudolf ; Beurden, Antony van ; Slingerland, Robbert Jan ; Horst, Peter G.J. ter ; A.Gosselink, T. Marcel ; Jan-Dambrink, Henk E ; Leeuwen, Maarten A.H. van ; Roolvink, Vincent ; Kedhi, Elvin ; Klungel, Olaf H ; Belitser, Svetlana V ; Angiolillo, Dominick J ; Pustjens, Tobias ; Rasoul, Saman ; Gho, Ben ; Stein, Mera ; Ruiters, Lex ; W.J. van 'Hof, Arnoud t</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g675-84d75a5ffcb91ec1682f92a06834e5fb58dfaa89474559aaad6acfe07a77e81b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetaminophen</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Evaluation</topic><topic>Heart attack</topic><topic>Opioids</topic><topic>Pain</topic><topic>Ticagrelor</topic><topic>Transluminal angioplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavenier, Anne H</creatorcontrib><creatorcontrib>Hermanides, Renicus S</creatorcontrib><creatorcontrib>Ottervanger, Jan Paul</creatorcontrib><creatorcontrib>Tolsma, Rudolf</creatorcontrib><creatorcontrib>Beurden, Antony van</creatorcontrib><creatorcontrib>Slingerland, Robbert Jan</creatorcontrib><creatorcontrib>Horst, Peter G.J. ter</creatorcontrib><creatorcontrib>A.Gosselink, T. Marcel</creatorcontrib><creatorcontrib>Jan-Dambrink, Henk E</creatorcontrib><creatorcontrib>Leeuwen, Maarten A.H. van</creatorcontrib><creatorcontrib>Roolvink, Vincent</creatorcontrib><creatorcontrib>Kedhi, Elvin</creatorcontrib><creatorcontrib>Klungel, Olaf H</creatorcontrib><creatorcontrib>Belitser, Svetlana V</creatorcontrib><creatorcontrib>Angiolillo, Dominick J</creatorcontrib><creatorcontrib>Pustjens, Tobias</creatorcontrib><creatorcontrib>Rasoul, Saman</creatorcontrib><creatorcontrib>Gho, Ben</creatorcontrib><creatorcontrib>Stein, Mera</creatorcontrib><creatorcontrib>Ruiters, Lex</creatorcontrib><creatorcontrib>W.J. van 'Hof, Arnoud t</creatorcontrib><jtitle>European heart journal. Cardiovascular pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavenier, Anne H</au><au>Hermanides, Renicus S</au><au>Ottervanger, Jan Paul</au><au>Tolsma, Rudolf</au><au>Beurden, Antony van</au><au>Slingerland, Robbert Jan</au><au>Horst, Peter G.J. ter</au><au>A.Gosselink, T. Marcel</au><au>Jan-Dambrink, Henk E</au><au>Leeuwen, Maarten A.H. van</au><au>Roolvink, Vincent</au><au>Kedhi, Elvin</au><au>Klungel, Olaf H</au><au>Belitser, Svetlana V</au><au>Angiolillo, Dominick J</au><au>Pustjens, Tobias</au><au>Rasoul, Saman</au><au>Gho, Ben</au><au>Stein, Mera</au><au>Ruiters, Lex</au><au>W.J. van 'Hof, Arnoud t</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of opioids on P2[Y.sub.12] receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation trial</atitle><jtitle>European heart journal. Cardiovascular pharmacotherapy</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>8</volume><issue>1</issue><spage>4</spage><pages>4-</pages><issn>2055-6837</issn><abstract>Aims Platelet inhibition induced by [P2Y.sub.12] receptor antagonists in patients with ST-elevation myocardial infarction (STEMI) can be affected by concomitant use of opioids. The aim of this trial was to examine the effect of intravenous (iv) acetaminophen compared with iv fentanyl on [P2Y.sub.12] receptor inhibition in patients with STEMI. Methods and The Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial randomized 195 STEMI results patients who were scheduled to undergo primary percutaneous coronary intervention (PCI) and were pre-treated with crushed ticagrelor to iv acetaminophen (N = 98) or iv fentanyl (N = 97) in the ambulance. The primary endpoint, consisting of the level of platelet reactivity units (PRU) measured immediately after primary PCI, was not significantly different between the study arms [median PRU 104 (IQR 37-215) vs. 175 (63-228), P= 0.18]. However, systemic levels of ticagrelor were significantly higher in the acetaminophen arm at the start of primary PCI [151 ng/mL (32-509) vs. 60 ng/mL (13-206), P= 0.007], immediately after primary PCI [326 ng/mL (94-791) vs. 115 ng/mL (38-326), P = 0.002], and at 1 h after primary PCI [488 ng/mL (281-974) vs. 372 ng/mL (95-635), P= 0.002]. Acetaminophen resulted in the same extent of pain relief when compared with fentanyl [reduction of 3 points on 10-step-pain scale before primary PCI (IQR 1-5)] in both study arms (P= 0.67) and immediately after PCI [reduction of 5 points (3-7); P= 0.96]. Conclusion The iv acetaminophen in comparison with iv fentanyl was not associated with significantly lower platelet reactivity in STEMI patients but resulted in significantly higher ticagrelor plasma levels and was effective in pain relief. Keywords ST-elevation myocardial infarction * Acetaminophen * Fentanyl * Acetaminophen * Primary coronary intervention * Ticagrelor</abstract><pub>Oxford University Press</pub><doi>10.1093/ehjcvp/pvaa095</doi></addata></record> |
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| subjects | Acetaminophen Care and treatment Comparative analysis Evaluation Heart attack Opioids Pain Ticagrelor Transluminal angioplasty |
| title | Impact of opioids on P2[Y.sub.12] receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation trial |
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