Placental Growth Factor and Adverse Obstetric Outcomes in a Mixed-Risk Cohort of Women Screened for Preeclampsia in the First Trimester of Pregnancy
Objective: The study aimed to investigate the association between placental growth factor (PlGF) and adverse obstetric outcomes in a mixed-risk cohort of pregnant women screened for preeclampsia (PE) in the first trimester. Methods: We included women with singleton pregnancies screened for PE betwee...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2021-04, Vol.48 (4), p.304-312 |
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| description | Objective: The study aimed to investigate the association between placental growth factor (PlGF) and adverse obstetric outcomes in a mixed-risk cohort of pregnant women screened for preeclampsia (PE) in the first trimester. Methods: We included women with singleton pregnancies screened for PE between April 2014 and September 2016. Outcome data were retrieved from the New South Wales Perinatal Data Collection (NSW PDC) by linkage to the prenatal cohort. Adverse outcomes were defined as spontaneous preterm birth (sPTB) before 37-week gestation, birth weight (BW) below the 3rd centile, PE, gestational hypertension (GH), stillbirth, and neonatal death. Results: The cohort consisted of 11,758 women. PlGF multiple of the median (MoM) was significantly associated with maternal sociodemographic characteristics (particularly smoking status and parity) and all biomarkers used in the PE first trimester screening model (notably pregnancy-associated plasma protein A MoM and uterine artery pulsatility index [PI] MoM). Low levels of PlGF ( |
| doi_str_mv | 10.1159/000514201 |
| format | Article |
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Methods: We included women with singleton pregnancies screened for PE between April 2014 and September 2016. Outcome data were retrieved from the New South Wales Perinatal Data Collection (NSW PDC) by linkage to the prenatal cohort. Adverse outcomes were defined as spontaneous preterm birth (sPTB) before 37-week gestation, birth weight (BW) below the 3rd centile, PE, gestational hypertension (GH), stillbirth, and neonatal death. Results: The cohort consisted of 11,758 women. PlGF multiple of the median (MoM) was significantly associated with maternal sociodemographic characteristics (particularly smoking status and parity) and all biomarkers used in the PE first trimester screening model (notably pregnancy-associated plasma protein A MoM and uterine artery pulsatility index [PI] MoM). Low levels of PlGF (<0.3 MoM and <0.5 MoM) were independently associated with sPTB, low BW, PE, GH, and a composite adverse pregnancy outcome score, with odds ratios between 1.81 and 4.44 on multivariable logistic regression analyses. Conclusions: Low PlGF MoM levels are independently associated with PE and a range of other adverse pregnancy outcomes. Inclusion of PlGF should be considered in future models screening for adverse pregnancy outcomes in the first trimester.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000514201</identifier><identifier>PMID: 33789295</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Angiogenin ; Biomarkers ; Childbirth ; Complications and side effects ; Diagnosis ; Female ; Health aspects ; Humans ; Infant, Newborn ; Medical screening ; Methods ; Placenta Growth Factor ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - epidemiology ; Preeclampsia ; Pregnancy ; Pregnancy Trimester, First ; Pregnant women ; Premature Birth - diagnosis ; Premature Birth - epidemiology ; Research Article ; Risk factors ; Uterine Artery - diagnostic imaging</subject><ispartof>Fetal diagnosis and therapy, 2021-04, Vol.48 (4), p.304-312</ispartof><rights>2021 S. Karger AG, Basel</rights><rights>2021 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-d83203db60f85415a2763a4a31b04bf5f5316949992827b249b6168767a4f3693</citedby><cites>FETCH-LOGICAL-c432t-d83203db60f85415a2763a4a31b04bf5f5316949992827b249b6168767a4f3693</cites><orcidid>0000-0002-8979-4534</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33789295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ekelund, Charlotte Kvist</creatorcontrib><creatorcontrib>Rode, Line</creatorcontrib><creatorcontrib>Tabor, Ann</creatorcontrib><creatorcontrib>Hyett, Jon</creatorcontrib><creatorcontrib>McLennan, Andrew</creatorcontrib><title>Placental Growth Factor and Adverse Obstetric Outcomes in a Mixed-Risk Cohort of Women Screened for Preeclampsia in the First Trimester of Pregnancy</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>Objective: The study aimed to investigate the association between placental growth factor (PlGF) and adverse obstetric outcomes in a mixed-risk cohort of pregnant women screened for preeclampsia (PE) in the first trimester. Methods: We included women with singleton pregnancies screened for PE between April 2014 and September 2016. Outcome data were retrieved from the New South Wales Perinatal Data Collection (NSW PDC) by linkage to the prenatal cohort. Adverse outcomes were defined as spontaneous preterm birth (sPTB) before 37-week gestation, birth weight (BW) below the 3rd centile, PE, gestational hypertension (GH), stillbirth, and neonatal death. Results: The cohort consisted of 11,758 women. PlGF multiple of the median (MoM) was significantly associated with maternal sociodemographic characteristics (particularly smoking status and parity) and all biomarkers used in the PE first trimester screening model (notably pregnancy-associated plasma protein A MoM and uterine artery pulsatility index [PI] MoM). Low levels of PlGF (<0.3 MoM and <0.5 MoM) were independently associated with sPTB, low BW, PE, GH, and a composite adverse pregnancy outcome score, with odds ratios between 1.81 and 4.44 on multivariable logistic regression analyses. Conclusions: Low PlGF MoM levels are independently associated with PE and a range of other adverse pregnancy outcomes. Inclusion of PlGF should be considered in future models screening for adverse pregnancy outcomes in the first trimester.</description><subject>Angiogenin</subject><subject>Biomarkers</subject><subject>Childbirth</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Medical screening</subject><subject>Methods</subject><subject>Placenta Growth Factor</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnant women</subject><subject>Premature Birth - diagnosis</subject><subject>Premature Birth - epidemiology</subject><subject>Research Article</subject><subject>Risk factors</subject><subject>Uterine Artery - diagnostic imaging</subject><issn>1015-3837</issn><issn>1421-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptklGPEyEQxzdG452nD74bQ2Ji9GFPWGBZHptqT5MzvWiNjxuWHbp4W6jAqvc9_MDStFYvufAwE_j9_zDDFMVTgs8J4fINxpgTVmFyrzjNkZRS1ux-zjHhJW2oOCkexfgtY42g9cPihFLRyEry0-L31ag0uKRGdBH8zzSghdLJB6Rcj2b9DwgR0LKLCVKwGi2npP0GIrIOKfTR_oK-_GTjNZr7wYeEvEFf87lDn3UAcNAjk72ucq5HtdlGq3bKNABa2BATWgWb3RKEnTJja6ecvnlcPDBqjPDkEM-KL4t3q_n78nJ58WE-uyw1o1Uq-4ZWmPZdjU3DGeGqEjVVTFHSYdYZbjgltWRSyqqpRFcx2dWkbkQtFDO0lvSseLX33Qb_fcrvaDc2ahhH5cBPsa04FoJiSVlGX-zRtRqhtc74FJTe4e1MYJIbyzHN1PkdVF49bKz2DozN-7cEL_8TDKDGNEQ_Tsl6F2-Dr_egDj7GAKbd5tapcNMS3O6GoD0OQWafH8qaug30R_Lvr_8r5lqFNYQjsHi72lu0295k6tmd1OGWP91Lvb8</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Ekelund, Charlotte Kvist</creator><creator>Rode, Line</creator><creator>Tabor, Ann</creator><creator>Hyett, Jon</creator><creator>McLennan, Andrew</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8979-4534</orcidid></search><sort><creationdate>20210401</creationdate><title>Placental Growth Factor and Adverse Obstetric Outcomes in a Mixed-Risk Cohort of Women Screened for Preeclampsia in the First Trimester of Pregnancy</title><author>Ekelund, Charlotte Kvist ; Rode, Line ; Tabor, Ann ; Hyett, Jon ; McLennan, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-d83203db60f85415a2763a4a31b04bf5f5316949992827b249b6168767a4f3693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiogenin</topic><topic>Biomarkers</topic><topic>Childbirth</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Medical screening</topic><topic>Methods</topic><topic>Placenta Growth Factor</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnant women</topic><topic>Premature Birth - diagnosis</topic><topic>Premature Birth - epidemiology</topic><topic>Research Article</topic><topic>Risk factors</topic><topic>Uterine Artery - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekelund, Charlotte Kvist</creatorcontrib><creatorcontrib>Rode, Line</creatorcontrib><creatorcontrib>Tabor, Ann</creatorcontrib><creatorcontrib>Hyett, Jon</creatorcontrib><creatorcontrib>McLennan, Andrew</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekelund, Charlotte Kvist</au><au>Rode, Line</au><au>Tabor, Ann</au><au>Hyett, Jon</au><au>McLennan, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental Growth Factor and Adverse Obstetric Outcomes in a Mixed-Risk Cohort of Women Screened for Preeclampsia in the First Trimester of Pregnancy</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>48</volume><issue>4</issue><spage>304</spage><epage>312</epage><pages>304-312</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>Objective: The study aimed to investigate the association between placental growth factor (PlGF) and adverse obstetric outcomes in a mixed-risk cohort of pregnant women screened for preeclampsia (PE) in the first trimester. Methods: We included women with singleton pregnancies screened for PE between April 2014 and September 2016. Outcome data were retrieved from the New South Wales Perinatal Data Collection (NSW PDC) by linkage to the prenatal cohort. Adverse outcomes were defined as spontaneous preterm birth (sPTB) before 37-week gestation, birth weight (BW) below the 3rd centile, PE, gestational hypertension (GH), stillbirth, and neonatal death. Results: The cohort consisted of 11,758 women. PlGF multiple of the median (MoM) was significantly associated with maternal sociodemographic characteristics (particularly smoking status and parity) and all biomarkers used in the PE first trimester screening model (notably pregnancy-associated plasma protein A MoM and uterine artery pulsatility index [PI] MoM). Low levels of PlGF (<0.3 MoM and <0.5 MoM) were independently associated with sPTB, low BW, PE, GH, and a composite adverse pregnancy outcome score, with odds ratios between 1.81 and 4.44 on multivariable logistic regression analyses. Conclusions: Low PlGF MoM levels are independently associated with PE and a range of other adverse pregnancy outcomes. Inclusion of PlGF should be considered in future models screening for adverse pregnancy outcomes in the first trimester.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>33789295</pmid><doi>10.1159/000514201</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8979-4534</orcidid></addata></record> |
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| ispartof | Fetal diagnosis and therapy, 2021-04, Vol.48 (4), p.304-312 |
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| source | Karger Journal Archive Collection; MEDLINE; Karger_医学期刊; Alma/SFX Local Collection |
| subjects | Angiogenin Biomarkers Childbirth Complications and side effects Diagnosis Female Health aspects Humans Infant, Newborn Medical screening Methods Placenta Growth Factor Pre-Eclampsia - diagnosis Pre-Eclampsia - epidemiology Preeclampsia Pregnancy Pregnancy Trimester, First Pregnant women Premature Birth - diagnosis Premature Birth - epidemiology Research Article Risk factors Uterine Artery - diagnostic imaging |
| title | Placental Growth Factor and Adverse Obstetric Outcomes in a Mixed-Risk Cohort of Women Screened for Preeclampsia in the First Trimester of Pregnancy |
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