Efficacy and safety of belimumab in the treatment of systemic lupus erythematosus: A meta‑analysis
The present meta-analysis aimed to systematically review the efficacy and safety of belimumab (BLM) therapy for patients with active and autoantibody-positive systemic lupus erythematosus (SLE) treated with standard of care (SOC). To evaluate the efficacy and safety of BLM plus SOC treatment in pati...
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| Veröffentlicht in: | World Academy of Sciences Journal 2022-03, Vol.4 (2), p.1, Article 8 |
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| description | The present meta-analysis aimed to systematically review the efficacy and safety of belimumab (BLM) therapy for patients with active and autoantibody-positive systemic lupus erythematosus (SLE) treated with standard of care (SOC). To evaluate the efficacy and safety of BLM plus SOC treatment in patients with active SLE, eligible studies were retrieved from the Web of Science, The Cochrane Library, PubMed and Embase online databases up to July, 2021. Review Manager (version 5.3) and STATA 16.0 software were used to analyze the extracted data from the included studies. A total of seven randomized controlled trials (RCTs) and 19 case series, with 4,235 and 2,597 patients with SLE, respectively were analyzed. In the RCTs, there were more SLE responder index (SRI-4) responders in the BLM group compared with the control group [52.8 vs. 41.6%; relative risk (RR), 1.27; 95% confidence interval (95% CI), 1.18-1.37); P |
| doi_str_mv | 10.3892/wasj.2022.143 |
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| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A701027754</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A701027754</galeid><sourcerecordid>A701027754</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2143-e627c76d2370fbe91424cb312156bcaf91e0497ba98f94746bbd18c2702f9dcf3</originalsourceid><addsrcrecordid>eNptUE1LxDAQDaLgsu7Re8Bza5KmzcbbsqwfsOBFz2GSJhpp2qVJkd78C_5Ff4ktK4Igc5hh5r3HvIfQJSV5sZbs-h3iW84IYznlxQlasKpgGZNUnv7OhJyjVYxeE85FVZKKLFC9c84bMCOGtsYRnE0j7hzWtvFhCKCxb3F6tTj1FlKwbZqvcYzJBm9wMxyGiG0_TpAAqYtDvMEbHGyCr49PaKEZo48X6MxBE-3qpy_R8-3uaXuf7R_vHrabfWbY9HRmKyaMqGpWCOK0lZQzbnRBGS0rbcBJagmXQoNcO8kFr7Su6dowQZiTtXHFEl0ddV-gscq3rks9mOCjURtBKGFClHxC5f-gpqpnS11rnZ_2fwjZkWD6LsbeOnXofYB-VJSoOXw1h6_m8NXko_gG_L941w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Efficacy and safety of belimumab in the treatment of systemic lupus erythematosus: A meta‑analysis</title><source>Alma/SFX Local Collection</source><creator>Zhang, Jiachen ; Liu, Xiangying ; Xu, Yan ; Li, Hongyan ; Xu, Yuexia</creator><creatorcontrib>Zhang, Jiachen ; Liu, Xiangying ; Xu, Yan ; Li, Hongyan ; Xu, Yuexia</creatorcontrib><description>The present meta-analysis aimed to systematically review the efficacy and safety of belimumab (BLM) therapy for patients with active and autoantibody-positive systemic lupus erythematosus (SLE) treated with standard of care (SOC). To evaluate the efficacy and safety of BLM plus SOC treatment in patients with active SLE, eligible studies were retrieved from the Web of Science, The Cochrane Library, PubMed and Embase online databases up to July, 2021. Review Manager (version 5.3) and STATA 16.0 software were used to analyze the extracted data from the included studies. A total of seven randomized controlled trials (RCTs) and 19 case series, with 4,235 and 2,597 patients with SLE, respectively were analyzed. In the RCTs, there were more SLE responder index (SRI-4) responders in the BLM group compared with the control group [52.8 vs. 41.6%; relative risk (RR), 1.27; 95% confidence interval (95% CI), 1.18-1.37); P<0.00001]. In addition, compared with the placebo group, more patients in the BLM group achieved a =4-point reduction in the Safety of Estrogens in Lupus National Assessment-Systemic Lupus Erythematosus Disease Activity Index score (RR, 1.26; 95% CI, 1.15-1.38; P<0.00001). Furthermore, treatment with BLM was found to significantly decrease the risk of severe disease exacerbations (flares) compared with the control group (RR, 0.72; 95% CI, 0.63-0.81; P<0.00001). Additionally, the corticosteroid dosage was reduced by =25 or 50% to =7.5 mg/day during weeks 40-52 in more patients in the BLM group compared with the control group (RR, 1.44; 95% CI, 1.17-1.76; P=0.0005). However, no differences were observed in the RR of adverse events (AEs) and severe AEs between both groups (RR, 1.00; 95% CI, 0.97-1.02; P=0.84; and RR, 0.80; 95% CI, 0.62-1.03; P=0.08, respectively). In the case series studies, the total remission rate was 60.5% (95% CI, 52.1-68.3%; P=0.015). In addition, treatment with BLM significantly decreased the use of corticosteroids (mean deviation, -8.73; 95% CI, -11.07 to -6.39; P<0.00001). Overall, the results of the present meta-analysis demonstrated that BLM therapy provided significant clinical efficacy and it was well-tolerated by patients with active SLE. More importantly, treatment with BLM may reduce the use of glucocorticoids. Key words: systemic lupus erythematosus, belimumab, meta-analysis, efficacy, safety</description><identifier>ISSN: 2632-2900</identifier><identifier>EISSN: 2632-2919</identifier><identifier>DOI: 10.3892/wasj.2022.143</identifier><language>eng</language><publisher>Spandidos Publications</publisher><subject>Analysis ; Autoantibodies ; Autoimmunity ; Belimumab ; Computer software industry ; Corticosteroids ; Drug therapy ; Lupus ; Medical research ; Medicine, Experimental ; Online databases ; Systemic lupus erythematosus</subject><ispartof>World Academy of Sciences Journal, 2022-03, Vol.4 (2), p.1, Article 8</ispartof><rights>COPYRIGHT 2022 Spandidos Publications</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2143-e627c76d2370fbe91424cb312156bcaf91e0497ba98f94746bbd18c2702f9dcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Zhang, Jiachen</creatorcontrib><creatorcontrib>Liu, Xiangying</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Li, Hongyan</creatorcontrib><creatorcontrib>Xu, Yuexia</creatorcontrib><title>Efficacy and safety of belimumab in the treatment of systemic lupus erythematosus: A meta‑analysis</title><title>World Academy of Sciences Journal</title><description>The present meta-analysis aimed to systematically review the efficacy and safety of belimumab (BLM) therapy for patients with active and autoantibody-positive systemic lupus erythematosus (SLE) treated with standard of care (SOC). To evaluate the efficacy and safety of BLM plus SOC treatment in patients with active SLE, eligible studies were retrieved from the Web of Science, The Cochrane Library, PubMed and Embase online databases up to July, 2021. Review Manager (version 5.3) and STATA 16.0 software were used to analyze the extracted data from the included studies. A total of seven randomized controlled trials (RCTs) and 19 case series, with 4,235 and 2,597 patients with SLE, respectively were analyzed. In the RCTs, there were more SLE responder index (SRI-4) responders in the BLM group compared with the control group [52.8 vs. 41.6%; relative risk (RR), 1.27; 95% confidence interval (95% CI), 1.18-1.37); P<0.00001]. In addition, compared with the placebo group, more patients in the BLM group achieved a =4-point reduction in the Safety of Estrogens in Lupus National Assessment-Systemic Lupus Erythematosus Disease Activity Index score (RR, 1.26; 95% CI, 1.15-1.38; P<0.00001). Furthermore, treatment with BLM was found to significantly decrease the risk of severe disease exacerbations (flares) compared with the control group (RR, 0.72; 95% CI, 0.63-0.81; P<0.00001). Additionally, the corticosteroid dosage was reduced by =25 or 50% to =7.5 mg/day during weeks 40-52 in more patients in the BLM group compared with the control group (RR, 1.44; 95% CI, 1.17-1.76; P=0.0005). However, no differences were observed in the RR of adverse events (AEs) and severe AEs between both groups (RR, 1.00; 95% CI, 0.97-1.02; P=0.84; and RR, 0.80; 95% CI, 0.62-1.03; P=0.08, respectively). In the case series studies, the total remission rate was 60.5% (95% CI, 52.1-68.3%; P=0.015). In addition, treatment with BLM significantly decreased the use of corticosteroids (mean deviation, -8.73; 95% CI, -11.07 to -6.39; P<0.00001). Overall, the results of the present meta-analysis demonstrated that BLM therapy provided significant clinical efficacy and it was well-tolerated by patients with active SLE. More importantly, treatment with BLM may reduce the use of glucocorticoids. Key words: systemic lupus erythematosus, belimumab, meta-analysis, efficacy, safety</description><subject>Analysis</subject><subject>Autoantibodies</subject><subject>Autoimmunity</subject><subject>Belimumab</subject><subject>Computer software industry</subject><subject>Corticosteroids</subject><subject>Drug therapy</subject><subject>Lupus</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Online databases</subject><subject>Systemic lupus erythematosus</subject><issn>2632-2900</issn><issn>2632-2919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptUE1LxDAQDaLgsu7Re8Bza5KmzcbbsqwfsOBFz2GSJhpp2qVJkd78C_5Ff4ktK4Igc5hh5r3HvIfQJSV5sZbs-h3iW84IYznlxQlasKpgGZNUnv7OhJyjVYxeE85FVZKKLFC9c84bMCOGtsYRnE0j7hzWtvFhCKCxb3F6tTj1FlKwbZqvcYzJBm9wMxyGiG0_TpAAqYtDvMEbHGyCr49PaKEZo48X6MxBE-3qpy_R8-3uaXuf7R_vHrabfWbY9HRmKyaMqGpWCOK0lZQzbnRBGS0rbcBJagmXQoNcO8kFr7Su6dowQZiTtXHFEl0ddV-gscq3rks9mOCjURtBKGFClHxC5f-gpqpnS11rnZ_2fwjZkWD6LsbeOnXofYB-VJSoOXw1h6_m8NXko_gG_L941w</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Zhang, Jiachen</creator><creator>Liu, Xiangying</creator><creator>Xu, Yan</creator><creator>Li, Hongyan</creator><creator>Xu, Yuexia</creator><general>Spandidos Publications</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220301</creationdate><title>Efficacy and safety of belimumab in the treatment of systemic lupus erythematosus: A meta‑analysis</title><author>Zhang, Jiachen ; Liu, Xiangying ; Xu, Yan ; Li, Hongyan ; Xu, Yuexia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2143-e627c76d2370fbe91424cb312156bcaf91e0497ba98f94746bbd18c2702f9dcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Autoantibodies</topic><topic>Autoimmunity</topic><topic>Belimumab</topic><topic>Computer software industry</topic><topic>Corticosteroids</topic><topic>Drug therapy</topic><topic>Lupus</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Online databases</topic><topic>Systemic lupus erythematosus</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jiachen</creatorcontrib><creatorcontrib>Liu, Xiangying</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Li, Hongyan</creatorcontrib><creatorcontrib>Xu, Yuexia</creatorcontrib><collection>CrossRef</collection><jtitle>World Academy of Sciences Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jiachen</au><au>Liu, Xiangying</au><au>Xu, Yan</au><au>Li, Hongyan</au><au>Xu, Yuexia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and safety of belimumab in the treatment of systemic lupus erythematosus: A meta‑analysis</atitle><jtitle>World Academy of Sciences Journal</jtitle><date>2022-03-01</date><risdate>2022</risdate><volume>4</volume><issue>2</issue><spage>1</spage><pages>1-</pages><artnum>8</artnum><issn>2632-2900</issn><eissn>2632-2919</eissn><abstract>The present meta-analysis aimed to systematically review the efficacy and safety of belimumab (BLM) therapy for patients with active and autoantibody-positive systemic lupus erythematosus (SLE) treated with standard of care (SOC). To evaluate the efficacy and safety of BLM plus SOC treatment in patients with active SLE, eligible studies were retrieved from the Web of Science, The Cochrane Library, PubMed and Embase online databases up to July, 2021. Review Manager (version 5.3) and STATA 16.0 software were used to analyze the extracted data from the included studies. A total of seven randomized controlled trials (RCTs) and 19 case series, with 4,235 and 2,597 patients with SLE, respectively were analyzed. In the RCTs, there were more SLE responder index (SRI-4) responders in the BLM group compared with the control group [52.8 vs. 41.6%; relative risk (RR), 1.27; 95% confidence interval (95% CI), 1.18-1.37); P<0.00001]. In addition, compared with the placebo group, more patients in the BLM group achieved a =4-point reduction in the Safety of Estrogens in Lupus National Assessment-Systemic Lupus Erythematosus Disease Activity Index score (RR, 1.26; 95% CI, 1.15-1.38; P<0.00001). Furthermore, treatment with BLM was found to significantly decrease the risk of severe disease exacerbations (flares) compared with the control group (RR, 0.72; 95% CI, 0.63-0.81; P<0.00001). Additionally, the corticosteroid dosage was reduced by =25 or 50% to =7.5 mg/day during weeks 40-52 in more patients in the BLM group compared with the control group (RR, 1.44; 95% CI, 1.17-1.76; P=0.0005). However, no differences were observed in the RR of adverse events (AEs) and severe AEs between both groups (RR, 1.00; 95% CI, 0.97-1.02; P=0.84; and RR, 0.80; 95% CI, 0.62-1.03; P=0.08, respectively). In the case series studies, the total remission rate was 60.5% (95% CI, 52.1-68.3%; P=0.015). In addition, treatment with BLM significantly decreased the use of corticosteroids (mean deviation, -8.73; 95% CI, -11.07 to -6.39; P<0.00001). Overall, the results of the present meta-analysis demonstrated that BLM therapy provided significant clinical efficacy and it was well-tolerated by patients with active SLE. More importantly, treatment with BLM may reduce the use of glucocorticoids. Key words: systemic lupus erythematosus, belimumab, meta-analysis, efficacy, safety</abstract><pub>Spandidos Publications</pub><doi>10.3892/wasj.2022.143</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Autoantibodies Autoimmunity Belimumab Computer software industry Corticosteroids Drug therapy Lupus Medical research Medicine, Experimental Online databases Systemic lupus erythematosus |
| title | Efficacy and safety of belimumab in the treatment of systemic lupus erythematosus: A meta‑analysis |
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