One-pot biosynthesis of 7[beta]-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum

7[beta]-hydroxylated steroids (7[beta]-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics. However, the production of 7[beta]-OHSt is still a challenge due to the lack of cheap 7[beta]-hydroxy precursor and the difficulty...

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Veröffentlicht in:	Microbial cell factories 2022-04, Vol.21 (1)
Hauptverfasser:	Zhao, Yun-Qiu, Liu, Yong-Jun, Ji, Wei-Ting, Liu, Kun, Gao, Bei, Tao, Xin-Yi, Zhao, Ming, Wang, Feng-Qing, Wei, Dong-Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory drugs Biosynthesis Dosage and administration Hydroxylation Methods Phytosterols Properties
Online-Zugang:	Volltext
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